Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes
Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophys...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2015-11, Vol.35 (11), p.1846-1851 |
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| creator | Feddersen, Berend Neupane, Pritam Thanbichler, Florian Hadolt, Irmgard Sattelmeyer, Vera Pfefferkorn, Thomas Waanders, Robb Noachtar, Soheyl Ausserer, Harald |
| description | Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ≥ 3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 m altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes. |
| doi_str_mv | 10.1038/jcbfm.2015.142 |
| format | Article |
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As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ≥ 3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 m altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/jcbfm.2015.142</identifier><identifier>PMID: 26082017</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acclimatization ; Adult ; Aged ; Alpha Rhythm ; Altitude Sickness - diagnostic imaging ; Altitude Sickness - physiopathology ; Beta Rhythm ; Blood Flow Velocity ; Blood Pressure ; Carbon Dioxide - metabolism ; Cerebral Arteries - physiopathology ; Cerebrovascular Circulation ; Electroencephalography ; Female ; Humans ; Hypoxia, Brain - diagnostic imaging ; Hypoxia, Brain - physiopathology ; Male ; Middle Aged ; Mountaineering ; Occipital Lobe - blood supply ; Original ; Oxygen Consumption ; Prospective Studies ; Ultrasonography ; Young Adult</subject><ispartof>Journal of cerebral blood flow and metabolism, 2015-11, Vol.35 (11), p.1846-1851</ispartof><rights>2015 ISCBFM</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc. 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-4f9bea6738eec5119f9e4086e3983bb4b8d40ecad5996330c51ac38dc29d0f13</citedby><cites>FETCH-LOGICAL-c557t-4f9bea6738eec5119f9e4086e3983bb4b8d40ecad5996330c51ac38dc29d0f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635241/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635241/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,21823,27928,27929,43625,43626,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26082017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feddersen, Berend</creatorcontrib><creatorcontrib>Neupane, Pritam</creatorcontrib><creatorcontrib>Thanbichler, Florian</creatorcontrib><creatorcontrib>Hadolt, Irmgard</creatorcontrib><creatorcontrib>Sattelmeyer, Vera</creatorcontrib><creatorcontrib>Pfefferkorn, Thomas</creatorcontrib><creatorcontrib>Waanders, Robb</creatorcontrib><creatorcontrib>Noachtar, Soheyl</creatorcontrib><creatorcontrib>Ausserer, Harald</creatorcontrib><title>Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ≥ 3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 m altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes.</description><subject>Acclimatization</subject><subject>Adult</subject><subject>Aged</subject><subject>Alpha Rhythm</subject><subject>Altitude Sickness - diagnostic imaging</subject><subject>Altitude Sickness - physiopathology</subject><subject>Beta Rhythm</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Carbon Dioxide - metabolism</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Cerebrovascular Circulation</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia, Brain - diagnostic imaging</subject><subject>Hypoxia, Brain - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mountaineering</subject><subject>Occipital Lobe - blood supply</subject><subject>Original</subject><subject>Oxygen Consumption</subject><subject>Prospective Studies</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc-LEzEUx4Mobq1ePUrAiyBT82OSSS7CWl0rLAjLIt5CJvOmTZlOapJR-9-bbtdlFQ-ekvA-7_vyvl-EnlOyoISrN1vX9rsFI1QsaM0eoBkVQlcNofIhmhHW0Eo26usZepLSlhCiuBCP0RmTRJWeZoY2V7D2YbQDfu_7HiKMDhL2I84bwMvybmOpvRtC6PDFEH7gLzAE5_MBX0HahzEBzgGvDvvQ2ujdze2nt9hmvPLrDT4fss9TB-kpetTbIcGz23OOri8-XC9X1eXnj5-W55eVE6LJVd3rFqxsuAJwglLda6iJksC14m1bt6qrCTjbCa0l56Qw1nHVOaY70lM-R29Psvup3UHnYMxlAbOPfmfjwQTrzZ-V0W_MOnw3teSC1UeBV7cCMXybIGWz88nBMNgRwpQMbaTQqjhJ_gNlSjY1La7P0cu_0G2YYrH9RLFaMXmcvThRLoaUIvR3_6bEHOM2N3GbY9ymxF0aXtzf9g7_nW8BXp-AZNdwb-a_5X4BSz-1Pw</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Feddersen, Berend</creator><creator>Neupane, Pritam</creator><creator>Thanbichler, Florian</creator><creator>Hadolt, Irmgard</creator><creator>Sattelmeyer, Vera</creator><creator>Pfefferkorn, Thomas</creator><creator>Waanders, Robb</creator><creator>Noachtar, Soheyl</creator><creator>Ausserer, Harald</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20151101</creationdate><title>Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes</title><author>Feddersen, Berend ; Neupane, Pritam ; Thanbichler, Florian ; Hadolt, Irmgard ; Sattelmeyer, Vera ; Pfefferkorn, Thomas ; Waanders, Robb ; Noachtar, Soheyl ; Ausserer, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-4f9bea6738eec5119f9e4086e3983bb4b8d40ecad5996330c51ac38dc29d0f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acclimatization</topic><topic>Adult</topic><topic>Aged</topic><topic>Alpha Rhythm</topic><topic>Altitude Sickness - diagnostic imaging</topic><topic>Altitude Sickness - physiopathology</topic><topic>Beta Rhythm</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Carbon Dioxide - metabolism</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Cerebrovascular Circulation</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia, Brain - diagnostic imaging</topic><topic>Hypoxia, Brain - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mountaineering</topic><topic>Occipital Lobe - blood supply</topic><topic>Original</topic><topic>Oxygen Consumption</topic><topic>Prospective Studies</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feddersen, Berend</creatorcontrib><creatorcontrib>Neupane, Pritam</creatorcontrib><creatorcontrib>Thanbichler, Florian</creatorcontrib><creatorcontrib>Hadolt, Irmgard</creatorcontrib><creatorcontrib>Sattelmeyer, Vera</creatorcontrib><creatorcontrib>Pfefferkorn, Thomas</creatorcontrib><creatorcontrib>Waanders, Robb</creatorcontrib><creatorcontrib>Noachtar, Soheyl</creatorcontrib><creatorcontrib>Ausserer, Harald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feddersen, Berend</au><au>Neupane, Pritam</au><au>Thanbichler, Florian</au><au>Hadolt, Irmgard</au><au>Sattelmeyer, Vera</au><au>Pfefferkorn, Thomas</au><au>Waanders, Robb</au><au>Noachtar, Soheyl</au><au>Ausserer, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>35</volume><issue>11</issue><spage>1846</spage><epage>1851</epage><pages>1846-1851</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><abstract>Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ≥ 3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 m altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26082017</pmid><doi>10.1038/jcbfm.2015.142</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; SAGE Journals Online; PubMed Central |
| subjects | Acclimatization Adult Aged Alpha Rhythm Altitude Sickness - diagnostic imaging Altitude Sickness - physiopathology Beta Rhythm Blood Flow Velocity Blood Pressure Carbon Dioxide - metabolism Cerebral Arteries - physiopathology Cerebrovascular Circulation Electroencephalography Female Humans Hypoxia, Brain - diagnostic imaging Hypoxia, Brain - physiopathology Male Middle Aged Mountaineering Occipital Lobe - blood supply Original Oxygen Consumption Prospective Studies Ultrasonography Young Adult |
| title | Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes |
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