Addressing health disparities in Hispanic breast cancer: accurate and inexpensive sequencing of BRCA1 and BRCA2

Abstract Background Germline mutations in the BRCA1 and BRCA2 genes account for 20–25 % of inherited breast cancers and about 10 % of all breast cancer cases. Detection of BRCA mutation carriers can lead to therapeutic interventions such as mastectomy, oophorectomy, hormonal prevention therapy, impr...

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Veröffentlicht in:	Gigascience 2015, Vol.4 (1), p.50
Hauptverfasser:	Dean, Michael, Boland, Joseph, Yeager, Meredith, Im, Kate M., Garland, Lisa, Rodriguez-Herrera, Maria, Perez, Mylen, Mitchell, Jason, Roberson, David, Jones, Kristine, Lee, Hyo Jung, Eggebeen, Rebecca, Sawitzke, Julie, Bass, Sara, Zhang, Xijun, Robles, Vivian, Hollis, Celia, Barajas, Claudia, Rath, Edna, Arentz, Candy, Figueroa, Jose A., Nguyen, Diane D., Nahleh, Zeina
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 protein BRCA2 protein Breast cancer Breast Neoplasms - genetics ErbB-2 protein Female Genes, BRCA1 Genes, BRCA2 Health disparities Hispanic or Latino - genetics Humans Mutation Nucleotide sequence Ovariectomy Saliva Therapeutic applications
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