Thermal Degradation of Small Molecules: A Global Metabolomic Investigation

Thermal processes are widely used in small molecule chemical analysis and metabolomics for derivatization, vaporization, chromatography, and ionization, especially in gas chromatography mass spectrometry (GC/MS). In this study the effect of heating was examined on a set of 64 small molecule standard...

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Veröffentlicht in:	Analytical chemistry (Washington) 2015-11, Vol.87 (21), p.10935-10941
Hauptverfasser:	Fang, Mingliang, Ivanisevic, Julijana, Benton, H. Paul, Johnson, Caroline H, Patti, Gary J, Hoang, Linh T, Uritboonthai, Winnie, Kurczy, Michael E, Siuzdak, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine diphosphate adenosine monophosphate adenosine triphosphate Analytical chemistry Blood chemical analysis Chromatography Chromatography, Liquid Degradation derivatization electrospray ionization mass spectrometry Exposure exposure duration Gas Chromatography-Mass Spectrometry heat Heating High temperature Humans hypoxanthine inosine monophosphate Ionization Liquid chromatography Male Mass spectrometry Metabolites Metabolomics nucleosides oleic acid Spectrometry, Mass, Electrospray Ionization Temperature thermal degradation volatilization
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