Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer
Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a l...
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| Veröffentlicht in: | Nature communications 2015-10, Vol.6 (1), p.8469, Article 8469 |
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| creator | Wang, Meilin Takahashi, Atsushi Liu, Fang Ye, Dingwei Ding, Qiang Qin, Chao Yin, Changjun Zhang, Zhengdong Matsuda, Koichi Kubo, Michiaki Na, Rong Lin, Xiaoling Jiang, Haowen Ren, Shancheng Sun, Jielin Zheng, S. Lilly Marchand, Loic Le Isaacs, William B. Mo, Zengnan Haiman, Christopher A. Sun, Yinghao Nakagawa, Hidewaki Xu, Jianfeng |
| description | Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447,
P
=3.59 × 10
−8
;
PPFIBP2
) and 14q23.2 (rs58262369,
P
=6.05 × 10
−10
;
ESR2
). The mRNA levels of
PPFIBP2
and
ESR2
are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2. |
| doi_str_mv | 10.1038/ncomms9469 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4633711</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3828835581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-8783fec26a1b90c36994396826db73871c09bc2d96bedf7ee2a6f5658ff83ded3</originalsourceid><addsrcrecordid>eNplkUtrGzEQx0VpqE2aSz5AEOTWsOlqJWulS8CEvMDQS3IWWu3IkVlLjmbd4G9fFefh0rnMwPzmPy9CTll9yWqufkaX1mvUQuovZNrUglWsbfjXg3hCThBXdTGumRLiG5k0UgguhJ4Su7B5CRU6OwC1iMkFO4YUqY122GFAGiKdY7CxRD3EMfgASCO8Utyig80YujCEcUeHUkp9ynSTE452BOpsdJC_kyNvB4STN39Mnm5vHq_vq8Wvu4fr-aJys1qNlWoV9-AaaVmna8el1oJrqRrZdy1XLXO17lzTa9lB71uAxko_kzPlveI99PyYXO11N9tuDb0rs2Y7mE0Oa5t3Jtlg_s3E8GyW6bcRkvOWsSJw_iaQ08sWcDSrtM3lDGhYy7RopGRtoX7sKVfWxAz-owOrzd-PmM-PFPjscKYP9P3-BbjYA1hScQn5oOf_cn8AyJeZVg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1719426617</pqid></control><display><type>article</type><title>Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Springer Nature OA Free Journals</source><creator>Wang, Meilin ; Takahashi, Atsushi ; Liu, Fang ; Ye, Dingwei ; Ding, Qiang ; Qin, Chao ; Yin, Changjun ; Zhang, Zhengdong ; Matsuda, Koichi ; Kubo, Michiaki ; Na, Rong ; Lin, Xiaoling ; Jiang, Haowen ; Ren, Shancheng ; Sun, Jielin ; Zheng, S. Lilly ; Marchand, Loic Le ; Isaacs, William B. ; Mo, Zengnan ; Haiman, Christopher A. ; Sun, Yinghao ; Nakagawa, Hidewaki ; Xu, Jianfeng</creator><creatorcontrib>Wang, Meilin ; Takahashi, Atsushi ; Liu, Fang ; Ye, Dingwei ; Ding, Qiang ; Qin, Chao ; Yin, Changjun ; Zhang, Zhengdong ; Matsuda, Koichi ; Kubo, Michiaki ; Na, Rong ; Lin, Xiaoling ; Jiang, Haowen ; Ren, Shancheng ; Sun, Jielin ; Zheng, S. Lilly ; Marchand, Loic Le ; Isaacs, William B. ; Mo, Zengnan ; Haiman, Christopher A. ; Sun, Yinghao ; Nakagawa, Hidewaki ; Xu, Jianfeng</creatorcontrib><description>Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447,
P
=3.59 × 10
−8
;
PPFIBP2
) and 14q23.2 (rs58262369,
P
=6.05 × 10
−10
;
ESR2
). The mRNA levels of
PPFIBP2
and
ESR2
are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms9469</identifier><identifier>PMID: 26443449</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/2324 ; 692/699/67/589/466 ; 692/699/67/68 ; Aged ; Asian Continental Ancestry Group - genetics ; Association analysis ; Cancer ; Carrier Proteins - genetics ; China ; Estrogen Receptor beta - genetics ; Gene loci ; Genetic Predisposition to Disease ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genotype ; Health risk assessment ; Health risks ; Humanities and Social Sciences ; Humans ; Intracellular Signaling Peptides and Proteins ; Japan ; Male ; Membrane Proteins - genetics ; Middle Aged ; mRNA ; multidisciplinary ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; RNA, Messenger - metabolism ; Science ; Science (multidisciplinary) ; Tumors</subject><ispartof>Nature communications, 2015-10, Vol.6 (1), p.8469, Article 8469</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Oct 2015</rights><rights>Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-8783fec26a1b90c36994396826db73871c09bc2d96bedf7ee2a6f5658ff83ded3</citedby><cites>FETCH-LOGICAL-c508t-8783fec26a1b90c36994396826db73871c09bc2d96bedf7ee2a6f5658ff83ded3</cites><orcidid>0000-0001-7292-2686</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633711/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633711/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26443449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Ye, Dingwei</creatorcontrib><creatorcontrib>Ding, Qiang</creatorcontrib><creatorcontrib>Qin, Chao</creatorcontrib><creatorcontrib>Yin, Changjun</creatorcontrib><creatorcontrib>Zhang, Zhengdong</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Na, Rong</creatorcontrib><creatorcontrib>Lin, Xiaoling</creatorcontrib><creatorcontrib>Jiang, Haowen</creatorcontrib><creatorcontrib>Ren, Shancheng</creatorcontrib><creatorcontrib>Sun, Jielin</creatorcontrib><creatorcontrib>Zheng, S. Lilly</creatorcontrib><creatorcontrib>Marchand, Loic Le</creatorcontrib><creatorcontrib>Isaacs, William B.</creatorcontrib><creatorcontrib>Mo, Zengnan</creatorcontrib><creatorcontrib>Haiman, Christopher A.</creatorcontrib><creatorcontrib>Sun, Yinghao</creatorcontrib><creatorcontrib>Nakagawa, Hidewaki</creatorcontrib><creatorcontrib>Xu, Jianfeng</creatorcontrib><title>Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447,
P
=3.59 × 10
−8
;
PPFIBP2
) and 14q23.2 (rs58262369,
P
=6.05 × 10
−10
;
ESR2
). The mRNA levels of
PPFIBP2
and
ESR2
are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.</description><subject>692/699/67/2324</subject><subject>692/699/67/589/466</subject><subject>692/699/67/68</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Association analysis</subject><subject>Cancer</subject><subject>Carrier Proteins - genetics</subject><subject>China</subject><subject>Estrogen Receptor beta - genetics</subject><subject>Gene loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Japan</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>mRNA</subject><subject>multidisciplinary</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tumors</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtrGzEQx0VpqE2aSz5AEOTWsOlqJWulS8CEvMDQS3IWWu3IkVlLjmbd4G9fFefh0rnMwPzmPy9CTll9yWqufkaX1mvUQuovZNrUglWsbfjXg3hCThBXdTGumRLiG5k0UgguhJ4Su7B5CRU6OwC1iMkFO4YUqY122GFAGiKdY7CxRD3EMfgASCO8Utyig80YujCEcUeHUkp9ynSTE452BOpsdJC_kyNvB4STN39Mnm5vHq_vq8Wvu4fr-aJys1qNlWoV9-AaaVmna8el1oJrqRrZdy1XLXO17lzTa9lB71uAxko_kzPlveI99PyYXO11N9tuDb0rs2Y7mE0Oa5t3Jtlg_s3E8GyW6bcRkvOWsSJw_iaQ08sWcDSrtM3lDGhYy7RopGRtoX7sKVfWxAz-owOrzd-PmM-PFPjscKYP9P3-BbjYA1hScQn5oOf_cn8AyJeZVg</recordid><startdate>20151007</startdate><enddate>20151007</enddate><creator>Wang, Meilin</creator><creator>Takahashi, Atsushi</creator><creator>Liu, Fang</creator><creator>Ye, Dingwei</creator><creator>Ding, Qiang</creator><creator>Qin, Chao</creator><creator>Yin, Changjun</creator><creator>Zhang, Zhengdong</creator><creator>Matsuda, Koichi</creator><creator>Kubo, Michiaki</creator><creator>Na, Rong</creator><creator>Lin, Xiaoling</creator><creator>Jiang, Haowen</creator><creator>Ren, Shancheng</creator><creator>Sun, Jielin</creator><creator>Zheng, S. 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Lilly ; Marchand, Loic Le ; Isaacs, William B. ; Mo, Zengnan ; Haiman, Christopher A. ; Sun, Yinghao ; Nakagawa, Hidewaki ; Xu, Jianfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-8783fec26a1b90c36994396826db73871c09bc2d96bedf7ee2a6f5658ff83ded3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/699/67/2324</topic><topic>692/699/67/589/466</topic><topic>692/699/67/68</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Association analysis</topic><topic>Cancer</topic><topic>Carrier Proteins - genetics</topic><topic>China</topic><topic>Estrogen Receptor beta - genetics</topic><topic>Gene loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Japan</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>mRNA</topic><topic>multidisciplinary</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Ye, Dingwei</creatorcontrib><creatorcontrib>Ding, Qiang</creatorcontrib><creatorcontrib>Qin, Chao</creatorcontrib><creatorcontrib>Yin, Changjun</creatorcontrib><creatorcontrib>Zhang, Zhengdong</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Na, Rong</creatorcontrib><creatorcontrib>Lin, Xiaoling</creatorcontrib><creatorcontrib>Jiang, Haowen</creatorcontrib><creatorcontrib>Ren, Shancheng</creatorcontrib><creatorcontrib>Sun, Jielin</creatorcontrib><creatorcontrib>Zheng, S. 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Lilly</au><au>Marchand, Loic Le</au><au>Isaacs, William B.</au><au>Mo, Zengnan</au><au>Haiman, Christopher A.</au><au>Sun, Yinghao</au><au>Nakagawa, Hidewaki</au><au>Xu, Jianfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2015-10-07</date><risdate>2015</risdate><volume>6</volume><issue>1</issue><spage>8469</spage><pages>8469-</pages><artnum>8469</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447,
P
=3.59 × 10
−8
;
PPFIBP2
) and 14q23.2 (rs58262369,
P
=6.05 × 10
−10
;
ESR2
). The mRNA levels of
PPFIBP2
and
ESR2
are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
Genetic variations influence the risk of prostate cancer. Here, the authors use a meta-analysis of Genome-wide association studies from Asian populations and uncover new susceptibility loci at 11p15.4 and 14q23.2.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26443449</pmid><doi>10.1038/ncomms9469</doi><orcidid>https://orcid.org/0000-0001-7292-2686</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2041-1723 |
| ispartof | Nature communications, 2015-10, Vol.6 (1), p.8469, Article 8469 |
| issn | 2041-1723 2041-1723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4633711 |
| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals |
| subjects | 692/699/67/2324 692/699/67/589/466 692/699/67/68 Aged Asian Continental Ancestry Group - genetics Association analysis Cancer Carrier Proteins - genetics China Estrogen Receptor beta - genetics Gene loci Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Health risk assessment Health risks Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins Japan Male Membrane Proteins - genetics Middle Aged mRNA multidisciplinary Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism RNA, Messenger - metabolism Science Science (multidisciplinary) Tumors |
| title | Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Large-scale%20association%20analysis%20in%20Asians%20identifies%20new%20susceptibility%20loci%20for%20prostate%20cancer&rft.jtitle=Nature%20communications&rft.au=Wang,%20Meilin&rft.date=2015-10-07&rft.volume=6&rft.issue=1&rft.spage=8469&rft.pages=8469-&rft.artnum=8469&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/ncomms9469&rft_dat=%3Cproquest_pubme%3E3828835581%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1719426617&rft_id=info:pmid/26443449&rfr_iscdi=true |