Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated r...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.16099-16099, Article 16099 |
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| creator | Liu, Wei Ling, Shukuan Sun, Weijia Liu, Tong Li, Yuheng Zhong, Guohui Zhao, Dingsheng Zhang, Pengfei Song, Jinping Jin, Xiaoyan Xu, Zi Song, Hailin Li, Qi Liu, Shujuan Chai, Meng Dai, Qinyi He, Yi Fan, Zhanming Zhou, Yu Jie Li, Yingxian |
| description | The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients. |
| doi_str_mv | 10.1038/srep16099 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4633594</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1731781596</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-6839f7413055096b8769858f4d56bd9a440585de6e4219fe5612f381a09650733</originalsourceid><addsrcrecordid>eNplkU2LFDEQhoMo7jLuwT8gAS8qjCadj04uwjL4BYuC6Dlk0tUzWbqTNuneZf-9tcw6jJpDKkk9vFWVl5DnnL3lTJh3tcDENbP2ETlvmFTrRjTN45PzGbmo9ZrhUo2V3D4lZ41WotUtOyf7TSxhGfwc046OMZT8_etlpSGXAvgKHb2N857Oe6AD3MBAc3-fzMmXO-rLDBiCH0LsY0CRnGhMtN6N05xHvAc64Q5prs_Ik94PFS4e4or8_Pjhx-bz-urbpy-by6t1kMLMa22E7VvJBVOKWb01rbZGmV52Sm8766VkyqgONMiG2x6U5k0vDPcIK9YKsSLvD7rTsh2hC1i7-MFNJY7Ysss-ur8zKe7dLt84qYVQVqLAqweBkn8tUGc3xhpgGHyCvFTHW8Fbw5XViL78B73OS0k4nuPG2tZqjpOsyOsDhZ9b0a3-2Axn7t5Cd7QQ2Ren3R_JP4Yh8OYAVEylHZSTkv-p_QZNcqX1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899796141</pqid></control><display><type>article</type><title>Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients</title><source>Nature Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Liu, Wei ; Ling, Shukuan ; Sun, Weijia ; Liu, Tong ; Li, Yuheng ; Zhong, Guohui ; Zhao, Dingsheng ; Zhang, Pengfei ; Song, Jinping ; Jin, Xiaoyan ; Xu, Zi ; Song, Hailin ; Li, Qi ; Liu, Shujuan ; Chai, Meng ; Dai, Qinyi ; He, Yi ; Fan, Zhanming ; Zhou, Yu Jie ; Li, Yingxian</creator><creatorcontrib>Liu, Wei ; Ling, Shukuan ; Sun, Weijia ; Liu, Tong ; Li, Yuheng ; Zhong, Guohui ; Zhao, Dingsheng ; Zhang, Pengfei ; Song, Jinping ; Jin, Xiaoyan ; Xu, Zi ; Song, Hailin ; Li, Qi ; Liu, Shujuan ; Chai, Meng ; Dai, Qinyi ; He, Yi ; Fan, Zhanming ; Zhou, Yu Jie ; Li, Yingxian</creatorcontrib><description>The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep16099</identifier><identifier>PMID: 26537670</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 45/90 ; 692/53/2421 ; 692/699/75/593/2193 ; Adult ; Aged ; Arteriosclerosis ; Calcification ; Calcification (ectopic) ; Calcinosis - pathology ; Calcium ; Cardiovascular disease ; Computed tomography ; Coronary artery ; Coronary Artery Disease - blood ; Coronary Artery Disease - pathology ; Coronary vessels ; Coronary Vessels - pathology ; Female ; Heart diseases ; Humanities and Social Sciences ; Humans ; Male ; Microarray Analysis ; MicroRNAs ; MicroRNAs - blood ; Middle Aged ; miRNA ; multidisciplinary ; Pain ; Science ; Tomography ; Up-Regulation - physiology</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.16099-16099, Article 16099</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-6839f7413055096b8769858f4d56bd9a440585de6e4219fe5612f381a09650733</citedby><cites>FETCH-LOGICAL-c438t-6839f7413055096b8769858f4d56bd9a440585de6e4219fe5612f381a09650733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633594/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633594/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27928,27929,41124,42193,51580,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26537670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Ling, Shukuan</creatorcontrib><creatorcontrib>Sun, Weijia</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Li, Yuheng</creatorcontrib><creatorcontrib>Zhong, Guohui</creatorcontrib><creatorcontrib>Zhao, Dingsheng</creatorcontrib><creatorcontrib>Zhang, Pengfei</creatorcontrib><creatorcontrib>Song, Jinping</creatorcontrib><creatorcontrib>Jin, Xiaoyan</creatorcontrib><creatorcontrib>Xu, Zi</creatorcontrib><creatorcontrib>Song, Hailin</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Liu, Shujuan</creatorcontrib><creatorcontrib>Chai, Meng</creatorcontrib><creatorcontrib>Dai, Qinyi</creatorcontrib><creatorcontrib>He, Yi</creatorcontrib><creatorcontrib>Fan, Zhanming</creatorcontrib><creatorcontrib>Zhou, Yu Jie</creatorcontrib><creatorcontrib>Li, Yingxian</creatorcontrib><title>Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.</description><subject>38/39</subject><subject>45/90</subject><subject>692/53/2421</subject><subject>692/699/75/593/2193</subject><subject>Adult</subject><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcinosis - pathology</subject><subject>Calcium</subject><subject>Cardiovascular disease</subject><subject>Computed tomography</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - pathology</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Microarray Analysis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>multidisciplinary</subject><subject>Pain</subject><subject>Science</subject><subject>Tomography</subject><subject>Up-Regulation - physiology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU2LFDEQhoMo7jLuwT8gAS8qjCadj04uwjL4BYuC6Dlk0tUzWbqTNuneZf-9tcw6jJpDKkk9vFWVl5DnnL3lTJh3tcDENbP2ETlvmFTrRjTN45PzGbmo9ZrhUo2V3D4lZ41WotUtOyf7TSxhGfwc046OMZT8_etlpSGXAvgKHb2N857Oe6AD3MBAc3-fzMmXO-rLDBiCH0LsY0CRnGhMtN6N05xHvAc64Q5prs_Ik94PFS4e4or8_Pjhx-bz-urbpy-by6t1kMLMa22E7VvJBVOKWb01rbZGmV52Sm8766VkyqgONMiG2x6U5k0vDPcIK9YKsSLvD7rTsh2hC1i7-MFNJY7Ysss-ur8zKe7dLt84qYVQVqLAqweBkn8tUGc3xhpgGHyCvFTHW8Fbw5XViL78B73OS0k4nuPG2tZqjpOsyOsDhZ9b0a3-2Axn7t5Cd7QQ2Ren3R_JP4Yh8OYAVEylHZSTkv-p_QZNcqX1</recordid><startdate>20151105</startdate><enddate>20151105</enddate><creator>Liu, Wei</creator><creator>Ling, Shukuan</creator><creator>Sun, Weijia</creator><creator>Liu, Tong</creator><creator>Li, Yuheng</creator><creator>Zhong, Guohui</creator><creator>Zhao, Dingsheng</creator><creator>Zhang, Pengfei</creator><creator>Song, Jinping</creator><creator>Jin, Xiaoyan</creator><creator>Xu, Zi</creator><creator>Song, Hailin</creator><creator>Li, Qi</creator><creator>Liu, Shujuan</creator><creator>Chai, Meng</creator><creator>Dai, Qinyi</creator><creator>He, Yi</creator><creator>Fan, Zhanming</creator><creator>Zhou, Yu Jie</creator><creator>Li, Yingxian</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151105</creationdate><title>Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients</title><author>Liu, Wei ; Ling, Shukuan ; Sun, Weijia ; Liu, Tong ; Li, Yuheng ; Zhong, Guohui ; Zhao, Dingsheng ; Zhang, Pengfei ; Song, Jinping ; Jin, Xiaoyan ; Xu, Zi ; Song, Hailin ; Li, Qi ; Liu, Shujuan ; Chai, Meng ; Dai, Qinyi ; He, Yi ; Fan, Zhanming ; Zhou, Yu Jie ; Li, Yingxian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-6839f7413055096b8769858f4d56bd9a440585de6e4219fe5612f381a09650733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>38/39</topic><topic>45/90</topic><topic>692/53/2421</topic><topic>692/699/75/593/2193</topic><topic>Adult</topic><topic>Aged</topic><topic>Arteriosclerosis</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcinosis - pathology</topic><topic>Calcium</topic><topic>Cardiovascular disease</topic><topic>Computed tomography</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - pathology</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Microarray Analysis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>multidisciplinary</topic><topic>Pain</topic><topic>Science</topic><topic>Tomography</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Ling, Shukuan</creatorcontrib><creatorcontrib>Sun, Weijia</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Li, Yuheng</creatorcontrib><creatorcontrib>Zhong, Guohui</creatorcontrib><creatorcontrib>Zhao, Dingsheng</creatorcontrib><creatorcontrib>Zhang, Pengfei</creatorcontrib><creatorcontrib>Song, Jinping</creatorcontrib><creatorcontrib>Jin, Xiaoyan</creatorcontrib><creatorcontrib>Xu, Zi</creatorcontrib><creatorcontrib>Song, Hailin</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Liu, Shujuan</creatorcontrib><creatorcontrib>Chai, Meng</creatorcontrib><creatorcontrib>Dai, Qinyi</creatorcontrib><creatorcontrib>He, Yi</creatorcontrib><creatorcontrib>Fan, Zhanming</creatorcontrib><creatorcontrib>Zhou, Yu Jie</creatorcontrib><creatorcontrib>Li, Yingxian</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Wei</au><au>Ling, Shukuan</au><au>Sun, Weijia</au><au>Liu, Tong</au><au>Li, Yuheng</au><au>Zhong, Guohui</au><au>Zhao, Dingsheng</au><au>Zhang, Pengfei</au><au>Song, Jinping</au><au>Jin, Xiaoyan</au><au>Xu, Zi</au><au>Song, Hailin</au><au>Li, Qi</au><au>Liu, Shujuan</au><au>Chai, Meng</au><au>Dai, Qinyi</au><au>He, Yi</au><au>Fan, Zhanming</au><au>Zhou, Yu Jie</au><au>Li, Yingxian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-05</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>16099</spage><epage>16099</epage><pages>16099-16099</pages><artnum>16099</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26537670</pmid><doi>10.1038/srep16099</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 38/39 45/90 692/53/2421 692/699/75/593/2193 Adult Aged Arteriosclerosis Calcification Calcification (ectopic) Calcinosis - pathology Calcium Cardiovascular disease Computed tomography Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - pathology Coronary vessels Coronary Vessels - pathology Female Heart diseases Humanities and Social Sciences Humans Male Microarray Analysis MicroRNAs MicroRNAs - blood Middle Aged miRNA multidisciplinary Pain Science Tomography Up-Regulation - physiology |
| title | Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients |
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