Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

Highlights • In vivo two-photon microscopy data collected from WT α-syn, E57K α-syn, APP, 3R-Tau and Non-tg mice. • Calcium transients AUCs were significantly increased for WT α-syn, E57K α-syn and APP mice with 1-Hz stimulus. • Two-photon microscopy data coupled to statistical classifiers create a...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.310, p.549-560
Hauptverfasser:	Overk, C.R, Rockenstein, E, Florio, J, Cheng, Q, Masliah, E
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals bio-assay Calcineurin Inhibitors - pharmacology Calcium Signaling - drug effects classifier Cluster Analysis Disease Models, Animal Female FK506 Mice Mice, Transgenic neurodegeneration Neurodegenerative Diseases - metabolism Neurology Physical Stimulation ROC Curve Somatosensory Cortex - drug effects Somatosensory Cortex - metabolism statistical pattern recognition Tacrolimus - pharmacology tau Proteins - genetics tau Proteins - metabolism two-photon Vibrissae
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Zusammenfassung:	Highlights • In vivo two-photon microscopy data collected from WT α-syn, E57K α-syn, APP, 3R-Tau and Non-tg mice. • Calcium transients AUCs were significantly increased for WT α-syn, E57K α-syn and APP mice with 1-Hz stimulus. • Two-photon microscopy data coupled to statistical classifiers create a bioassay to identify different mouse types. • Our statistical classifier bioassay confirmed that FK506 normalized WT α-syn calcium transients.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.068