Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways

Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial properties. We examined the underlying mechanisms of dried pomegranate concentrate powder (PCP) on melanin...

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Veröffentlicht in:	International journal of molecular sciences 2015-10, Vol.16 (10), p.24219-24242
Hauptverfasser:	Kang, Su Jin, Choi, Beom Rak, Lee, Eun Kyoung, Kim, Seung Hee, Yi, Hae Yeon, Park, Hye Rim, Song, Chang Hyun, Lee, Young Joon, Ku, Sae Kwang
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - pharmacology Animals Antioxidants - pharmacology Cell Line, Tumor Cells CREB-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Flowers & plants Free Radical Scavengers - pharmacology Freeze Drying Fruits Glutathione Peroxidase - metabolism Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Kinases Melanins - biosynthesis Melanoma Melanoma, Experimental - drug therapy Mice Microphthalmia-Associated Transcription Factor - metabolism Monophenol Monooxygenase - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinase - metabolism Phosphorylation - drug effects Plant Preparations - pharmacology Proteins Proto-Oncogene Proteins c-akt - metabolism Punicaceae - metabolism Signal transduction
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