PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation by growth factors and amino acids have been extensively studied, the upstream regulatory mechanisms leading to mTORC2 activation remain larg...

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Veröffentlicht in:	Cancer discovery 2015-11, Vol.5 (11), p.1194-1209
Hauptverfasser:	Liu, Pengda, Gan, Wenjian, Chin, Y Rebecca, Ogura, Kohei, Guo, Jianping, Zhang, Jinfang, Wang, Bin, Blenis, John, Cantley, Lewis C, Toker, Alex, Su, Bing, Wei, Wenyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Motifs Animals Binding Sites Catalysis Cell Line, Tumor Disease Models, Animal Enzyme Activation Female Heterografts Humans Mechanistic Target of Rapamycin Complex 2 Mice Models, Molecular Molecular Conformation Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Phosphatidylinositol Phosphates - chemistry Phosphatidylinositol Phosphates - metabolism Phosphorylation Protein Binding Protein Interaction Domains and Motifs - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins p21(ras) - chemistry Proto-Oncogene Proteins p21(ras) - genetics TOR Serine-Threonine Kinases - chemistry TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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