Calcitonin gene‐related peptide in the joint: contributions to pain and inflammation

Arthritis is the commonest cause of disabling chronic pain, and both osteoarthritis (OA) and rheumatoid arthritis (RA) remain major burdens on both individuals and society. Peripheral release of calcitonin gene‐related peptide (CGRP) contributes to the vasodilation of acute neurogenic inflammation....

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Veröffentlicht in:	British journal of clinical pharmacology 2015-11, Vol.80 (5), p.965-978
Hauptverfasser:	Walsh, David A., Mapp, Paul I., Kelly, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - metabolism Disease Models, Animal Endothelial Cells - physiology Humans inflammation Inflammation - metabolism Inflammation - physiopathology joints Joints - metabolism Joints - physiopathology Models, Biological Neovascularization, Pathologic - physiopathology pain Pain - metabolism Pain - physiopathology Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors Reviews
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