Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice

Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. The recent increase in CD incidence suggests that additional environmental factors, such as intestinal microbiota alterations, are involved in its pathogenesis. However, there is no dire...

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Veröffentlicht in:	The American journal of pathology 2015-11, Vol.185 (11), p.2969-2982
Hauptverfasser:	Galipeau, Heather J, McCarville, Justin L, Huebener, Sina, Litwin, Owen, Meisel, Marlies, Jabri, Bana, Sanz, Yolanda, Murray, Joseph A, Jordana, Manel, Alaedini, Armin, Chirdo, Fernando G, Verdu, Elena F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Antibodies - blood Celiac Disease - immunology Celiac Disease - microbiology Celiac Disease - pathology Cell Proliferation Cytokines - analysis Feces - microbiology Female Gastrointestinal Microbiome Gliadin - adverse effects Glutens - adverse effects Humans Male Mice Mice, Inbred NOD Pathology Regular Specific Pathogen-Free Organisms T-Lymphocytes - immunology Vancomycin - administration & dosage
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