Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition

We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60%...

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Veröffentlicht in:Journal of developmental origins of health and disease 2015-12, Vol.6 (6), p.530-538
Hauptverfasser: Desai, M., Jellyman, J. K., Han, G., Lane, R. H., Ross, M. G.
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container_issue 6
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container_title Journal of developmental origins of health and disease
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creator Desai, M.
Jellyman, J. K.
Han, G.
Lane, R. H.
Ross, M. G.
description We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60% kcal) or control (10% kcal) diet before mating, and throughout pregnancy and lactation (Mat-OB). Additional dams were 50% food-restricted from pregnancy day 10 to term [intrauterine growth-restricted (IUGR)]. Adipose tissue protein expression was analyzed in newborn and adult male offspring. Normal birth weight Mat-OB and low birth weight IUGR newborns had upregulated PPARγ with variable changes in co-repressors and co-activators. As obese adults, Mat-OB and IUGR offspring had increased PPARγ with decreased co-repressor and increased co-activator expression. Nutritionally programmed increased PPARγ expression is associated with altered expression of its co-regulators in the newborn and adult offspring. Functional studies of PPARγ co-regulators are necessary to establish their role in PPARγ-mediated programmed obesity.
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subjects Adipose Tissue - metabolism
Animals
Birth Weight
Blood Glucose
Body Size
Diet, High-Fat
Female
Gene Expression Regulation, Developmental
Insulin - blood
Insulin resistance
Laboratories
Maternal Nutritional Physiological Phenomena
Nutrition
Obesity
Original Article
PPAR gamma - genetics
PPAR gamma - metabolism
Rats
Rodents
Triglycerides - blood
title Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition
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