Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer

Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetration. Mechanical disruption of the stroma can b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-09, Vol.75 (18), p.3738-3746
Hauptverfasser:	Li, Tong, Wang, Yak-Nam, Khokhlova, Tatiana D, D'Andrea, Samantha, Starr, Frank, Chen, Hong, McCune, Jeannine S, Risler, Linda J, Mashadi-Hossein, Afshin, Hingorani, Sunil R, Chang, Amy, Hwang, Joo Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Diffusion Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Equipment Design High-Energy Shock Waves Mice Mice, Transgenic Microscopy, Fluorescence Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Phonophoresis - instrumentation Phonophoresis - methods Random Allocation Stromal Cells - pathology Tandem Mass Spectrometry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!