Heterogeneity of miR-10b expression in circulating tumor cells
Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as ‘liquid biopsy’ to aid clinical decision-making. Recent work has revealed potentially...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.15980-15980, Article 15980 |
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| creator | Gasch, Christin Plummer, Prue N. Jovanovic, Lidija McInnes, Linda M. Wescott, David Saunders, Christobel M. Schneeweiss, Andreas Wallwiener, Markus Nelson, Colleen Spring, Kevin J. Riethdorf, Sabine Thompson, Erik W. Pantel, Klaus Mellick, Albert S. |
| description | Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as ‘liquid biopsy’ to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust
in situ
hybridization (
ISH
) protocol, incorporating the CellSearch
®
CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients. |
| doi_str_mv | 10.1038/srep15980 |
| format | Article |
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in situ
hybridization (
ISH
) protocol, incorporating the CellSearch
®
CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep15980</identifier><identifier>PMID: 26522916</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 631/67/322 ; 692/699/67/2329 ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Biopsy ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer ; Cell Line, Tumor ; Colorectal carcinoma ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Decision making ; Female ; Gene expression ; HCT116 Cells ; Heterogeneity ; Humanities and Social Sciences ; Humans ; In Situ Hybridization ; MCF-7 Cells ; Metastases ; MicroRNAs - genetics ; miRNA ; multidisciplinary ; Neoplastic Cells, Circulating - metabolism ; Prostate cancer ; Science ; Tumor cells</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.15980-15980, Article 15980</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-24dfc4054e9985f8b947a4a4888a7e42fb6dcbce289ae8e4e07829cef7a649533</citedby><cites>FETCH-LOGICAL-c438t-24dfc4054e9985f8b947a4a4888a7e42fb6dcbce289ae8e4e07829cef7a649533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629160/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629160/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26522916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasch, Christin</creatorcontrib><creatorcontrib>Plummer, Prue N.</creatorcontrib><creatorcontrib>Jovanovic, Lidija</creatorcontrib><creatorcontrib>McInnes, Linda M.</creatorcontrib><creatorcontrib>Wescott, David</creatorcontrib><creatorcontrib>Saunders, Christobel M.</creatorcontrib><creatorcontrib>Schneeweiss, Andreas</creatorcontrib><creatorcontrib>Wallwiener, Markus</creatorcontrib><creatorcontrib>Nelson, Colleen</creatorcontrib><creatorcontrib>Spring, Kevin J.</creatorcontrib><creatorcontrib>Riethdorf, Sabine</creatorcontrib><creatorcontrib>Thompson, Erik W.</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Mellick, Albert S.</creatorcontrib><title>Heterogeneity of miR-10b expression in circulating tumor cells</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as ‘liquid biopsy’ to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust
in situ
hybridization (
ISH
) protocol, incorporating the CellSearch
®
CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.</description><subject>13/51</subject><subject>631/67/322</subject><subject>692/699/67/2329</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Decision making</subject><subject>Female</subject><subject>Gene expression</subject><subject>HCT116 Cells</subject><subject>Heterogeneity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>MCF-7 Cells</subject><subject>Metastases</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>multidisciplinary</subject><subject>Neoplastic Cells, Circulating - metabolism</subject><subject>Prostate cancer</subject><subject>Science</subject><subject>Tumor cells</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkUFLxDAQhYMoKroH_4AUvKhQTdKkTS6CiLqCIIieQ5qdrpE2WZNW3H9vll2XVecyA_PxZh4PoSOCLwguxGUMMCNcCryF9ilmPKcFpdsb8x4axfiOU3EqGZG7aI-WnFJJyn10NYYegp-CA9vPM99knX3OCa4z-JoFiNF6l1mXGRvM0OreumnWD50PmYG2jYdop9FthNGqH6DXu9uXm3H--HT_cHP9mBtWiD6nbNIYhjkDKQVvRC1ZpZlmQghdAaNNXU5MbYAKqUEAA1wJKg00lS6Z5EVxgK6WurOh7mBiwPVBt2oWbKfDXHlt1e-Ns29q6j8VKxc-cRI4XQkE_zFA7FVn48KCduCHqEhFZcEJYyKhJ3_Qdz8El-wpIqSsZJlaos6WlAk-pgya9TMEq0Uwah1MYo83v1-TPzEk4HwJxLRyUwgbJ_-pfQP3kJdQ</recordid><startdate>20151102</startdate><enddate>20151102</enddate><creator>Gasch, Christin</creator><creator>Plummer, Prue N.</creator><creator>Jovanovic, Lidija</creator><creator>McInnes, Linda M.</creator><creator>Wescott, David</creator><creator>Saunders, Christobel M.</creator><creator>Schneeweiss, Andreas</creator><creator>Wallwiener, Markus</creator><creator>Nelson, Colleen</creator><creator>Spring, Kevin J.</creator><creator>Riethdorf, Sabine</creator><creator>Thompson, Erik W.</creator><creator>Pantel, Klaus</creator><creator>Mellick, Albert S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151102</creationdate><title>Heterogeneity of miR-10b expression in circulating tumor cells</title><author>Gasch, Christin ; Plummer, Prue N. ; Jovanovic, Lidija ; McInnes, Linda M. ; Wescott, David ; Saunders, Christobel M. ; Schneeweiss, Andreas ; Wallwiener, Markus ; Nelson, Colleen ; Spring, Kevin J. ; Riethdorf, Sabine ; Thompson, Erik W. ; Pantel, Klaus ; Mellick, Albert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-24dfc4054e9985f8b947a4a4888a7e42fb6dcbce289ae8e4e07829cef7a649533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13/51</topic><topic>631/67/322</topic><topic>692/699/67/2329</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Decision making</topic><topic>Female</topic><topic>Gene expression</topic><topic>HCT116 Cells</topic><topic>Heterogeneity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>MCF-7 Cells</topic><topic>Metastases</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>multidisciplinary</topic><topic>Neoplastic Cells, Circulating - metabolism</topic><topic>Prostate cancer</topic><topic>Science</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasch, Christin</creatorcontrib><creatorcontrib>Plummer, Prue N.</creatorcontrib><creatorcontrib>Jovanovic, Lidija</creatorcontrib><creatorcontrib>McInnes, Linda M.</creatorcontrib><creatorcontrib>Wescott, David</creatorcontrib><creatorcontrib>Saunders, Christobel M.</creatorcontrib><creatorcontrib>Schneeweiss, Andreas</creatorcontrib><creatorcontrib>Wallwiener, Markus</creatorcontrib><creatorcontrib>Nelson, Colleen</creatorcontrib><creatorcontrib>Spring, Kevin J.</creatorcontrib><creatorcontrib>Riethdorf, Sabine</creatorcontrib><creatorcontrib>Thompson, Erik W.</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Mellick, Albert S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gasch, Christin</au><au>Plummer, Prue N.</au><au>Jovanovic, Lidija</au><au>McInnes, Linda M.</au><au>Wescott, David</au><au>Saunders, Christobel M.</au><au>Schneeweiss, Andreas</au><au>Wallwiener, Markus</au><au>Nelson, Colleen</au><au>Spring, Kevin J.</au><au>Riethdorf, Sabine</au><au>Thompson, Erik W.</au><au>Pantel, Klaus</au><au>Mellick, Albert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneity of miR-10b expression in circulating tumor cells</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-02</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>15980</spage><epage>15980</epage><pages>15980-15980</pages><artnum>15980</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as ‘liquid biopsy’ to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust
in situ
hybridization (
ISH
) protocol, incorporating the CellSearch
®
CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26522916</pmid><doi>10.1038/srep15980</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/51 631/67/322 692/699/67/2329 Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell Line, Tumor Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Decision making Female Gene expression HCT116 Cells Heterogeneity Humanities and Social Sciences Humans In Situ Hybridization MCF-7 Cells Metastases MicroRNAs - genetics miRNA multidisciplinary Neoplastic Cells, Circulating - metabolism Prostate cancer Science Tumor cells |
| title | Heterogeneity of miR-10b expression in circulating tumor cells |
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