Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization
In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2–5 years of age. In 2014, this was extended to children 1–5 years old. During 2012–2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneu...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.15843-15843, Article 15843 |
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| description | In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2–5 years of age. In 2014, this was extended to children 1–5 years old. During 2012–2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (
P
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| doi_str_mv | 10.1038/srep15843 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4629140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899796267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-7f9d1ca26f312ae680b9248d32ca75f5119e4bb9f54d4ccdb81e9ad8e57b18093</originalsourceid><addsrcrecordid>eNplkU1rFTEUhoMottQu_AMy4EaFq8mZZCbZCKXUDyi40XXIZM7cmzKTjEnmQl36y0079XKr2eTryZPDeQl5yeh7Rmv5IUWcmZC8fkJOgXKxgRrg6dH6hJyndEPLEKA4U8_JCTQCQAE9Jb-v9mHcO7-tZo_LFGyw1oxVwhjy7YypMr4vu58LeovVeuR8FXE02QVf5VDt3HZXsOw6F7KzVcoR0_rQBt-7O64oH_ndNC3e_bp3vCDPBjMmPH-Yz8iPT1ffL79srr99_np5cb2xvJZ50w6qZ9ZAM9QMDDaSdgq47GuwphWDYEwh7zo1CN5za_tOMlSmlyjajkmq6jPycfXOSzdhb9HnaEY9RzeZeKuDcfrxjXc7vQ17zRtQjNMiePMgiKE0JGU9uWRxHI3HsCTNWlC1AHmPvv4HvQlLLG0olFSqVQ00baHerpSNIZUch0MxjOq7cPUh3MK-Oq7-QP6NsgDvViCVK7_FePTlf7Y_QcyykA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899796267</pqid></control><display><type>article</type><title>Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Su, Lin-Hui ; Kuo, An-Jing ; Chia, Ju-Hsin ; Li, Hsin-Chieh ; Wu, Tsu-Lan ; Feng, Ye ; Chiu, Cheng-Hsun</creator><creatorcontrib>Su, Lin-Hui ; Kuo, An-Jing ; Chia, Ju-Hsin ; Li, Hsin-Chieh ; Wu, Tsu-Lan ; Feng, Ye ; Chiu, Cheng-Hsun</creatorcontrib><description>In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2–5 years of age. In 2014, this was extended to children 1–5 years old. During 2012–2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (
P
< 0.001) and from 3.2 to 1.9 for IPD (
P
< 0.05). Significant reduction of PCV13 serotypes was firstly noted in children in 2013 and extended to both paediatric and adult populations in 2014. Simultaneously, the incidence per 10,000 admissions of non-PCV13 serotypes increased from 6.1 in 2012 to 9.3 in 2014 (
P
< 0.005). The most prevalent non-PCV13 serotypes were 15A, 15B and 23A, each containing a predominant clone, ST63
15A
, ST83
15B
and ST338
23A
. From 2012 to 2014, isolates with penicillin minimum inhibitory concentrations >2 mg/L decreased from 27.8% to 8.1% (
P
< 0.001) among all isolates. PCV13 immunization in young children demonstrated an early protective effect in all ages. However, in the elderly, the effect was compromised by an emergence of non-PCV13 serotypes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep15843</identifier><identifier>PMID: 26522920</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/23 ; 45/77 ; 631/326/590 ; 692/699/255/1318 ; Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - immunology ; Antibiotics ; Child ; Child, Preschool ; Children ; Female ; Geriatrics ; Hospitalization ; Humanities and Social Sciences ; Humans ; Immunization ; Immunization - methods ; Incidence ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; multidisciplinary ; Penicillin ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - immunology ; Pneumococcal Vaccines - immunology ; Prevalence ; Science ; Serogroup ; Serotypes ; Serotyping - methods ; Streptococcus pneumoniae - immunology ; Taiwan - epidemiology ; Vaccination - methods ; Vaccines ; Vaccines, Conjugate - immunology ; Young Adult</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.15843-15843, Article 15843</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-7f9d1ca26f312ae680b9248d32ca75f5119e4bb9f54d4ccdb81e9ad8e57b18093</citedby><cites>FETCH-LOGICAL-c438t-7f9d1ca26f312ae680b9248d32ca75f5119e4bb9f54d4ccdb81e9ad8e57b18093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629140/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629140/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26522920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Lin-Hui</creatorcontrib><creatorcontrib>Kuo, An-Jing</creatorcontrib><creatorcontrib>Chia, Ju-Hsin</creatorcontrib><creatorcontrib>Li, Hsin-Chieh</creatorcontrib><creatorcontrib>Wu, Tsu-Lan</creatorcontrib><creatorcontrib>Feng, Ye</creatorcontrib><creatorcontrib>Chiu, Cheng-Hsun</creatorcontrib><title>Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2–5 years of age. In 2014, this was extended to children 1–5 years old. During 2012–2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (
P
< 0.001) and from 3.2 to 1.9 for IPD (
P
< 0.05). Significant reduction of PCV13 serotypes was firstly noted in children in 2013 and extended to both paediatric and adult populations in 2014. Simultaneously, the incidence per 10,000 admissions of non-PCV13 serotypes increased from 6.1 in 2012 to 9.3 in 2014 (
P
< 0.005). The most prevalent non-PCV13 serotypes were 15A, 15B and 23A, each containing a predominant clone, ST63
15A
, ST83
15B
and ST338
23A
. From 2012 to 2014, isolates with penicillin minimum inhibitory concentrations >2 mg/L decreased from 27.8% to 8.1% (
P
< 0.001) among all isolates. PCV13 immunization in young children demonstrated an early protective effect in all ages. However, in the elderly, the effect was compromised by an emergence of non-PCV13 serotypes.</description><subject>45</subject><subject>45/23</subject><subject>45/77</subject><subject>631/326/590</subject><subject>692/699/255/1318</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - immunology</subject><subject>Antibiotics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Hospitalization</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization - methods</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Penicillin</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - immunology</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Prevalence</subject><subject>Science</subject><subject>Serogroup</subject><subject>Serotypes</subject><subject>Serotyping - methods</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Taiwan - epidemiology</subject><subject>Vaccination - methods</subject><subject>Vaccines</subject><subject>Vaccines, Conjugate - immunology</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU1rFTEUhoMottQu_AMy4EaFq8mZZCbZCKXUDyi40XXIZM7cmzKTjEnmQl36y0079XKr2eTryZPDeQl5yeh7Rmv5IUWcmZC8fkJOgXKxgRrg6dH6hJyndEPLEKA4U8_JCTQCQAE9Jb-v9mHcO7-tZo_LFGyw1oxVwhjy7YypMr4vu58LeovVeuR8FXE02QVf5VDt3HZXsOw6F7KzVcoR0_rQBt-7O64oH_ndNC3e_bp3vCDPBjMmPH-Yz8iPT1ffL79srr99_np5cb2xvJZ50w6qZ9ZAM9QMDDaSdgq47GuwphWDYEwh7zo1CN5za_tOMlSmlyjajkmq6jPycfXOSzdhb9HnaEY9RzeZeKuDcfrxjXc7vQ17zRtQjNMiePMgiKE0JGU9uWRxHI3HsCTNWlC1AHmPvv4HvQlLLG0olFSqVQ00baHerpSNIZUch0MxjOq7cPUh3MK-Oq7-QP6NsgDvViCVK7_FePTlf7Y_QcyykA</recordid><startdate>20151102</startdate><enddate>20151102</enddate><creator>Su, Lin-Hui</creator><creator>Kuo, An-Jing</creator><creator>Chia, Ju-Hsin</creator><creator>Li, Hsin-Chieh</creator><creator>Wu, Tsu-Lan</creator><creator>Feng, Ye</creator><creator>Chiu, Cheng-Hsun</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151102</creationdate><title>Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization</title><author>Su, Lin-Hui ; Kuo, An-Jing ; Chia, Ju-Hsin ; Li, Hsin-Chieh ; Wu, Tsu-Lan ; Feng, Ye ; Chiu, Cheng-Hsun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-7f9d1ca26f312ae680b9248d32ca75f5119e4bb9f54d4ccdb81e9ad8e57b18093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>45</topic><topic>45/23</topic><topic>45/77</topic><topic>631/326/590</topic><topic>692/699/255/1318</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - immunology</topic><topic>Antibiotics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Hospitalization</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization - methods</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Penicillin</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - immunology</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Prevalence</topic><topic>Science</topic><topic>Serogroup</topic><topic>Serotypes</topic><topic>Serotyping - methods</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Taiwan - epidemiology</topic><topic>Vaccination - methods</topic><topic>Vaccines</topic><topic>Vaccines, Conjugate - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Lin-Hui</creatorcontrib><creatorcontrib>Kuo, An-Jing</creatorcontrib><creatorcontrib>Chia, Ju-Hsin</creatorcontrib><creatorcontrib>Li, Hsin-Chieh</creatorcontrib><creatorcontrib>Wu, Tsu-Lan</creatorcontrib><creatorcontrib>Feng, Ye</creatorcontrib><creatorcontrib>Chiu, Cheng-Hsun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Lin-Hui</au><au>Kuo, An-Jing</au><au>Chia, Ju-Hsin</au><au>Li, Hsin-Chieh</au><au>Wu, Tsu-Lan</au><au>Feng, Ye</au><au>Chiu, Cheng-Hsun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-02</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>15843</spage><epage>15843</epage><pages>15843-15843</pages><artnum>15843</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2–5 years of age. In 2014, this was extended to children 1–5 years old. During 2012–2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (IPD), were prospectively identified and analyzed at a 3,700-bed hospital in Taiwan. From 2012 to 2014, the incidence per 10,000 admissions decreased from 26.7 to 20.4 for CCPD (
P
< 0.001) and from 3.2 to 1.9 for IPD (
P
< 0.05). Significant reduction of PCV13 serotypes was firstly noted in children in 2013 and extended to both paediatric and adult populations in 2014. Simultaneously, the incidence per 10,000 admissions of non-PCV13 serotypes increased from 6.1 in 2012 to 9.3 in 2014 (
P
< 0.005). The most prevalent non-PCV13 serotypes were 15A, 15B and 23A, each containing a predominant clone, ST63
15A
, ST83
15B
and ST338
23A
. From 2012 to 2014, isolates with penicillin minimum inhibitory concentrations >2 mg/L decreased from 27.8% to 8.1% (
P
< 0.001) among all isolates. PCV13 immunization in young children demonstrated an early protective effect in all ages. However, in the elderly, the effect was compromised by an emergence of non-PCV13 serotypes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26522920</pmid><doi>10.1038/srep15843</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45 45/23 45/77 631/326/590 692/699/255/1318 Adolescent Adult Aged Anti-Bacterial Agents - immunology Antibiotics Child Child, Preschool Children Female Geriatrics Hospitalization Humanities and Social Sciences Humans Immunization Immunization - methods Incidence Infant Male Microbial Sensitivity Tests Middle Aged multidisciplinary Penicillin Pneumococcal Infections - epidemiology Pneumococcal Infections - immunology Pneumococcal Vaccines - immunology Prevalence Science Serogroup Serotypes Serotyping - methods Streptococcus pneumoniae - immunology Taiwan - epidemiology Vaccination - methods Vaccines Vaccines, Conjugate - immunology Young Adult |
| title | Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization |
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