Histone methylation modifiers in cellular signaling pathways
Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effec...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2015-12, Vol.72 (23), p.4577-4592 |
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| creator | Alam, Hunain Gu, Bingnan Lee, Min Gyu |
| description | Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα. |
| doi_str_mv | 10.1007/s00018-015-2023-y |
| format | Article |
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These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-015-2023-y</identifier><identifier>PMID: 26305020</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amino Acid Sequence ; Arginine - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell differentiation ; gene expression ; Histone Methyltransferases ; Histone-Lysine N-Methyltransferase - chemistry ; Histone-Lysine N-Methyltransferase - metabolism ; histones ; Histones - metabolism ; Humans ; Life Sciences ; Lysine - metabolism ; MAP Kinase Signaling System ; Methylation ; methyltransferases ; mitogen-activated protein kinase ; Molecular Sequence Data ; NF-kappa B - metabolism ; oncogenes ; Phosphatidylinositol 3-Kinases - metabolism ; Proto-Oncogene Proteins c-akt - metabolism ; Proto-Oncogene Proteins c-raf - metabolism ; Review ; Signal Transduction ; transcription factor NF-kappa B ; tumor suppressor genes ; Wnt Signaling Pathway</subject><ispartof>Cellular and molecular life sciences : CMLS, 2015-12, Vol.72 (23), p.4577-4592</ispartof><rights>Springer Basel 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-9224ba52c66186bd10551913a39db48e459c378d898bf46fe36d35a863a22b3c3</citedby><cites>FETCH-LOGICAL-c630t-9224ba52c66186bd10551913a39db48e459c378d898bf46fe36d35a863a22b3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628846/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628846/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,27921,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26305020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alam, Hunain</creatorcontrib><creatorcontrib>Gu, Bingnan</creatorcontrib><creatorcontrib>Lee, Min Gyu</creatorcontrib><title>Histone methylation modifiers in cellular signaling pathways</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.</description><subject>Amino Acid Sequence</subject><subject>Arginine - metabolism</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell differentiation</subject><subject>gene expression</subject><subject>Histone Methyltransferases</subject><subject>Histone-Lysine N-Methyltransferase - chemistry</subject><subject>Histone-Lysine N-Methyltransferase - metabolism</subject><subject>histones</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lysine - metabolism</subject><subject>MAP Kinase Signaling System</subject><subject>Methylation</subject><subject>methyltransferases</subject><subject>mitogen-activated protein kinase</subject><subject>Molecular Sequence Data</subject><subject>NF-kappa B - metabolism</subject><subject>oncogenes</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Proto-Oncogene Proteins c-raf - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>transcription factor NF-kappa B</subject><subject>tumor suppressor genes</subject><subject>Wnt Signaling Pathway</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcFL5DAYxYOsrK67f4AXLXjxUv2SNGkKiyDi7ggDHnaFvYW0TTsZ2mRMWqX__Wbo7KB78JTA93vvy8tD6BTDFQbIrwMAYJECZikBQtPpAB3jjEBaQI4_7e5ckD9H6EsI6wgzQfhndEQ4BQYEjtH3hQmDszrp9bCaOjUYZ5Pe1aYx2ofE2KTSXTd2yifBtFZ1xrbJRg2rVzWFr-iwUV3Q33bnCXr6cf_7bpEuH38-3N0u0yruGdKCkKxUjFScY8HLGgNjuMBU0aIuM6EzVlQ0F7UoRNlkvNGU15QpwakipKQVPUE3s-9mLHtdV9oOXnVy402v_CSdMvL9xJqVbN2LzDgRIuPR4HJn4N3zqMMgexO2wZTVbgwS50RwLgSIiF78h67d6GPwmaJM0GxL4ZmqvAvB62b_GAxy242cu5Hxy-W2GzlFzdnbFHvFvzIiQGYgxJFttX-z-gPX81nUKCdV602QT78IYB7JvChwTv8CP6CjPg</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Alam, Hunain</creator><creator>Gu, Bingnan</creator><creator>Lee, Min Gyu</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Histone methylation modifiers in cellular signaling pathways</title><author>Alam, Hunain ; Gu, Bingnan ; Lee, Min Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-9224ba52c66186bd10551913a39db48e459c378d898bf46fe36d35a863a22b3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amino Acid Sequence</topic><topic>Arginine - metabolism</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cell differentiation</topic><topic>gene expression</topic><topic>Histone Methyltransferases</topic><topic>Histone-Lysine N-Methyltransferase - chemistry</topic><topic>Histone-Lysine N-Methyltransferase - metabolism</topic><topic>histones</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lysine - metabolism</topic><topic>MAP Kinase Signaling System</topic><topic>Methylation</topic><topic>methyltransferases</topic><topic>mitogen-activated protein kinase</topic><topic>Molecular Sequence Data</topic><topic>NF-kappa B - metabolism</topic><topic>oncogenes</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Proto-Oncogene Proteins c-raf - metabolism</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>transcription factor NF-kappa B</topic><topic>tumor suppressor genes</topic><topic>Wnt Signaling Pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alam, Hunain</creatorcontrib><creatorcontrib>Gu, Bingnan</creatorcontrib><creatorcontrib>Lee, Min Gyu</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>72</volume><issue>23</issue><spage>4577</spage><epage>4592</epage><pages>4577-4592</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26305020</pmid><doi>10.1007/s00018-015-2023-y</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Arginine - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell differentiation gene expression Histone Methyltransferases Histone-Lysine N-Methyltransferase - chemistry Histone-Lysine N-Methyltransferase - metabolism histones Histones - metabolism Humans Life Sciences Lysine - metabolism MAP Kinase Signaling System Methylation methyltransferases mitogen-activated protein kinase Molecular Sequence Data NF-kappa B - metabolism oncogenes Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-raf - metabolism Review Signal Transduction transcription factor NF-kappa B tumor suppressor genes Wnt Signaling Pathway |
| title | Histone methylation modifiers in cellular signaling pathways |
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