PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis

Mitotic kinases are the key components of the cell cycle machinery and play vital roles in cell cycle progression. PLK-1 (Polo-like kinase-1) is a crucial mitotic protein kinase that plays an essential role in both the onset of G2/M transition and cytokinesis. The overexpression of PLK-1 is strongly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-21
Hauptverfasser:	Kumar, Shiv, Kim, Jaebong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Cancer Cancer therapies Carcinogenesis Carcinogenesis - drug effects Cell cycle Cell Cycle - drug effects Cell Cycle Proteins - antagonists & inhibitors Cell growth Clinical trials Defects Dosage and administration Enzyme inhibitors Humans Kinases Medical prognosis Mitosis - drug effects Neurosciences Polo-Like Kinase 1 Polypeptides Prevention Protein Kinase Inhibitors - therapeutic use Protein Serine-Threonine Kinases - antagonists & inhibitors Proteins Proto-Oncogene Proteins - antagonists & inhibitors Review Small Molecule Libraries - therapeutic use Studies Toxicity Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!