Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5
Aims Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-r...
Gespeichert in:
| Veröffentlicht in: | Acta diabetologica 2015-12, Vol.52 (6), p.1121-1127 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1127 |
|---|---|
| container_issue | 6 |
| container_start_page | 1121 |
| container_title | Acta diabetologica |
| container_volume | 52 |
| creator | Xiang, Yufei Huang, Gan Shan, Zhongyan Pan, Linlin Luo, Shuoming Yang, Liyong Shi, Lixin Li, Qifu Leslie, R. David Zhou, Zhiguang |
| description | Aims
Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
Methods
LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (
n
= 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
Results
Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (
P
|
| doi_str_mv | 10.1007/s00592-015-0799-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4628082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3852270061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-2359976391c91e78a2d35289a594a403d2867583479a2ee9e1d680abecda9b353</originalsourceid><addsrcrecordid>eNqNUsuKFDEULURx2tEPcCMBN26ieVYlLoSm1VFocKPrkKqkpjNUJT15jPZf-YmmusdhFARXCcm555GcpnmO0WuMUPcmIcQlgQhziDopoXjQrDCjBHJC6cNmhSRDkDMiz5onKV0hhElHxePmjLSESszYqvl5MZWsZzcAPTgDjB107MOPw6STBbrkoH12fTDOJqCjBSbMztcz0JcMnE9lHN3gbD3IAThTN248gDmkDDY7521l-e7yDmhTpgyDTzYDHzxcRifnQbTXxUXnL49ibp6LryJO9zbb9BZs1-_XRyINUi7mAPjT5tGop2Sf3a7nzbePH75uPsHtl4vPm_UWDryjGRLKpezamnKQ2HZCE0M5EVJzyTRD1BDRdlxQ1klNrJUWm1agKjsYLXvK6Xnz7sS7L_1szVCTRT2pfXSzjgcVtFN_3ni3U5fhRrGWCCRIJXh1SxDDdbEpq9mlwU6T9jaUpHDHWiFJdfkf0MUtatnC-vIv6FUo0deXOKJojXQ0j0-oIYaUoh3vfGOkluqoU3VUrY5aqqNEnXlxP_DdxO-uVAA5AdJ--TAb70n_k_UXXGXSTw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1728358335</pqid></control><display><type>article</type><title>Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Xiang, Yufei ; Huang, Gan ; Shan, Zhongyan ; Pan, Linlin ; Luo, Shuoming ; Yang, Liyong ; Shi, Lixin ; Li, Qifu ; Leslie, R. David ; Zhou, Zhiguang</creator><creatorcontrib>Xiang, Yufei ; Huang, Gan ; Shan, Zhongyan ; Pan, Linlin ; Luo, Shuoming ; Yang, Liyong ; Shi, Lixin ; Li, Qifu ; Leslie, R. David ; Zhou, Zhiguang</creatorcontrib><description>Aims
Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
Methods
LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (
n
= 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
Results
Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (
P
< 0.05).
Conclusions
As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-015-0799-8</identifier><identifier>PMID: 26239144</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Acids ; Adult ; Aged ; Asian Continental Ancestry Group ; Autoantibodies - analysis ; Autoimmune diseases ; Biomarkers ; Cation Transport Proteins - immunology ; China ; Diabetes ; Diabetes Mellitus, Type 2 - diagnosis ; Female ; Glutamate Decarboxylase - immunology ; Humans ; Insulin ; Internal Medicine ; Islets of Langerhans - immunology ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Monoclonal antibodies ; Original ; Original Article ; Prevalence ; Protein Phosphatase 2 - immunology ; Zinc Transporter 8</subject><ispartof>Acta diabetologica, 2015-12, Vol.52 (6), p.1121-1127</ispartof><rights>The Author(s) 2015</rights><rights>Springer-Verlag Italia 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-2359976391c91e78a2d35289a594a403d2867583479a2ee9e1d680abecda9b353</citedby><cites>FETCH-LOGICAL-c573t-2359976391c91e78a2d35289a594a403d2867583479a2ee9e1d680abecda9b353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-015-0799-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-015-0799-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26239144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiang, Yufei</creatorcontrib><creatorcontrib>Huang, Gan</creatorcontrib><creatorcontrib>Shan, Zhongyan</creatorcontrib><creatorcontrib>Pan, Linlin</creatorcontrib><creatorcontrib>Luo, Shuoming</creatorcontrib><creatorcontrib>Yang, Liyong</creatorcontrib><creatorcontrib>Shi, Lixin</creatorcontrib><creatorcontrib>Li, Qifu</creatorcontrib><creatorcontrib>Leslie, R. David</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><title>Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
Methods
LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (
n
= 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
Results
Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (
P
< 0.05).
Conclusions
As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Autoantibodies - analysis</subject><subject>Autoimmune diseases</subject><subject>Biomarkers</subject><subject>Cation Transport Proteins - immunology</subject><subject>China</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Female</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Islets of Langerhans - immunology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Original</subject><subject>Original Article</subject><subject>Prevalence</subject><subject>Protein Phosphatase 2 - immunology</subject><subject>Zinc Transporter 8</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNUsuKFDEULURx2tEPcCMBN26ieVYlLoSm1VFocKPrkKqkpjNUJT15jPZf-YmmusdhFARXCcm555GcpnmO0WuMUPcmIcQlgQhziDopoXjQrDCjBHJC6cNmhSRDkDMiz5onKV0hhElHxePmjLSESszYqvl5MZWsZzcAPTgDjB107MOPw6STBbrkoH12fTDOJqCjBSbMztcz0JcMnE9lHN3gbD3IAThTN248gDmkDDY7521l-e7yDmhTpgyDTzYDHzxcRifnQbTXxUXnL49ibp6LryJO9zbb9BZs1-_XRyINUi7mAPjT5tGop2Sf3a7nzbePH75uPsHtl4vPm_UWDryjGRLKpezamnKQ2HZCE0M5EVJzyTRD1BDRdlxQ1klNrJUWm1agKjsYLXvK6Xnz7sS7L_1szVCTRT2pfXSzjgcVtFN_3ni3U5fhRrGWCCRIJXh1SxDDdbEpq9mlwU6T9jaUpHDHWiFJdfkf0MUtatnC-vIv6FUo0deXOKJojXQ0j0-oIYaUoh3vfGOkluqoU3VUrY5aqqNEnXlxP_DdxO-uVAA5AdJ--TAb70n_k_UXXGXSTw</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Xiang, Yufei</creator><creator>Huang, Gan</creator><creator>Shan, Zhongyan</creator><creator>Pan, Linlin</creator><creator>Luo, Shuoming</creator><creator>Yang, Liyong</creator><creator>Shi, Lixin</creator><creator>Li, Qifu</creator><creator>Leslie, R. David</creator><creator>Zhou, Zhiguang</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5</title><author>Xiang, Yufei ; Huang, Gan ; Shan, Zhongyan ; Pan, Linlin ; Luo, Shuoming ; Yang, Liyong ; Shi, Lixin ; Li, Qifu ; Leslie, R. David ; Zhou, Zhiguang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-2359976391c91e78a2d35289a594a403d2867583479a2ee9e1d680abecda9b353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Autoantibodies - analysis</topic><topic>Autoimmune diseases</topic><topic>Biomarkers</topic><topic>Cation Transport Proteins - immunology</topic><topic>China</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Female</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>Humans</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Islets of Langerhans - immunology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Original</topic><topic>Original Article</topic><topic>Prevalence</topic><topic>Protein Phosphatase 2 - immunology</topic><topic>Zinc Transporter 8</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, Yufei</creatorcontrib><creatorcontrib>Huang, Gan</creatorcontrib><creatorcontrib>Shan, Zhongyan</creatorcontrib><creatorcontrib>Pan, Linlin</creatorcontrib><creatorcontrib>Luo, Shuoming</creatorcontrib><creatorcontrib>Yang, Liyong</creatorcontrib><creatorcontrib>Shi, Lixin</creatorcontrib><creatorcontrib>Li, Qifu</creatorcontrib><creatorcontrib>Leslie, R. David</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, Yufei</au><au>Huang, Gan</au><au>Shan, Zhongyan</au><au>Pan, Linlin</au><au>Luo, Shuoming</au><au>Yang, Liyong</au><au>Shi, Lixin</au><au>Li, Qifu</au><au>Leslie, R. David</au><au>Zhou, Zhiguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>52</volume><issue>6</issue><spage>1121</spage><epage>1127</epage><pages>1121-1127</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><coden>ACDAEZ</coden><abstract>Aims
Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects.
Methods
LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (
n
= 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally.
Results
Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (
P
< 0.05).
Conclusions
As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>26239144</pmid><doi>10.1007/s00592-015-0799-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-5429 |
| ispartof | Acta diabetologica, 2015-12, Vol.52 (6), p.1121-1127 |
| issn | 0940-5429 1432-5233 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4628082 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acids Adult Aged Asian Continental Ancestry Group Autoantibodies - analysis Autoimmune diseases Biomarkers Cation Transport Proteins - immunology China Diabetes Diabetes Mellitus, Type 2 - diagnosis Female Glutamate Decarboxylase - immunology Humans Insulin Internal Medicine Islets of Langerhans - immunology Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Monoclonal antibodies Original Original Article Prevalence Protein Phosphatase 2 - immunology Zinc Transporter 8 |
| title | Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T12%3A56%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutamic%20acid%20decarboxylase%20autoantibodies%20are%20dominant%20but%20insufficient%20to%20identify%20most%20Chinese%20with%20adult-onset%20non-insulin%20requiring%20autoimmune%20diabetes:%20LADA%20China%20study%205&rft.jtitle=Acta%20diabetologica&rft.au=Xiang,%20Yufei&rft.date=2015-12-01&rft.volume=52&rft.issue=6&rft.spage=1121&rft.epage=1127&rft.pages=1121-1127&rft.issn=0940-5429&rft.eissn=1432-5233&rft.coden=ACDAEZ&rft_id=info:doi/10.1007/s00592-015-0799-8&rft_dat=%3Cproquest_pubme%3E3852270061%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1728358335&rft_id=info:pmid/26239144&rfr_iscdi=true |