Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities

Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a posttranslational modification which forms the nucleic acid-like polymer PAR. PARP1 and PAR are integral players in the early DNA damage response, since PARylation orchestrates the recruitmen...

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Veröffentlicht in:	Molecular and cellular biology 2015-12, Vol.35 (23), p.3974-3989
Hauptverfasser:	Khadka, Prabhat, Hsu, Joseph K., Veith, Sebastian, Tadokoro, Takashi, Shamanna, Raghavendra A., Mangerich, Aswin, Croteau, Deborah L., Bohr, Vilhelm A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism DNA Breaks, Double-Stranded DNA Repair Enzyme Activation - drug effects Exodeoxyribonucleases - metabolism HEK293 Cells HeLa Cells Humans Poly (ADP-Ribose) Polymerase-1 Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism Protein Interaction Maps RecQ Helicases - metabolism Werner Syndrome Helicase
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