Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes
Among patients with diabetes and stable heart disease, those with troponin T levels of 14 ng per liter or more had a 5-year rate of cardiovascular death, MI, or stroke of 27%, versus 13% in those with lower levels, but received no benefit from prompt revascularization. Cardiac troponin concentration...
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| Veröffentlicht in: | The New England journal of medicine 2015-08, Vol.373 (7), p.610-620 |
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| container_title | The New England journal of medicine |
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| creator | Everett, Brendan M Brooks, Maria Mori Vlachos, Helen E.A Chaitman, Bernard R Frye, Robert L Bhatt, Deepak L |
| description | Among patients with diabetes and stable heart disease, those with troponin T levels of 14 ng per liter or more had a 5-year rate of cardiovascular death, MI, or stroke of 27%, versus 13% in those with lower levels, but received no benefit from prompt revascularization.
Cardiac troponin concentration is the preferred marker of myocardial necrosis.
1
Elevated concentrations of cardiac troponin have a strong association with an adverse prognosis in patients with acute coronary syndromes and are used to identify patients who are likely to benefit from an early invasive management strategy.
2
–
4
High-sensitivity assays that allow the measurement of very low cardiac troponin levels in patients with stable heart disease are now available for clinical and research use. These low, previously undetectable troponin concentrations have shown strong associations with myocardial infarction, stroke, and death in a variety of primary and secondary prevention populations, including in . . . |
| doi_str_mv | 10.1056/NEJMoa1415921 |
| format | Article |
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Cardiac troponin concentration is the preferred marker of myocardial necrosis.
1
Elevated concentrations of cardiac troponin have a strong association with an adverse prognosis in patients with acute coronary syndromes and are used to identify patients who are likely to benefit from an early invasive management strategy.
2
–
4
High-sensitivity assays that allow the measurement of very low cardiac troponin levels in patients with stable heart disease are now available for clinical and research use. These low, previously undetectable troponin concentrations have shown strong associations with myocardial infarction, stroke, and death in a variety of primary and secondary prevention populations, including in . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1415921</identifier><identifier>PMID: 26267622</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acute coronary syndromes ; Aged ; Angioplasty ; Biomarkers - blood ; Calcium-binding protein ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cerebral infarction ; Coronary artery disease ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Fees & charges ; Female ; Follow-Up Studies ; Grants ; Health risk assessment ; Heart attacks ; Heart diseases ; Heart failure ; Humans ; Ischemia ; Kaplan-Meier Estimate ; Laboratories ; Male ; Middle Aged ; Mortality ; Myocardial infarction ; Myocardial Infarction - etiology ; Myocardial Ischemia - blood ; Myocardial Ischemia - complications ; Proteins ; Risk Factors ; Stroke ; Stroke - etiology ; Troponin ; Troponin T ; Troponin T - blood ; Womens health</subject><ispartof>The New England journal of medicine, 2015-08, Vol.373 (7), p.610-620</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-ad1775baefb85f81b2e3e249e70025c29937a3b96d8561cbfea729a3f6f72a333</citedby><cites>FETCH-LOGICAL-c539t-ad1775baefb85f81b2e3e249e70025c29937a3b96d8561cbfea729a3f6f72a333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1415921$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1415921$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26267622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Everett, Brendan M</creatorcontrib><creatorcontrib>Brooks, Maria Mori</creatorcontrib><creatorcontrib>Vlachos, Helen E.A</creatorcontrib><creatorcontrib>Chaitman, Bernard R</creatorcontrib><creatorcontrib>Frye, Robert L</creatorcontrib><creatorcontrib>Bhatt, Deepak L</creatorcontrib><creatorcontrib>BARI 2D Study Group</creatorcontrib><title>Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Among patients with diabetes and stable heart disease, those with troponin T levels of 14 ng per liter or more had a 5-year rate of cardiovascular death, MI, or stroke of 27%, versus 13% in those with lower levels, but received no benefit from prompt revascularization.
Cardiac troponin concentration is the preferred marker of myocardial necrosis.
1
Elevated concentrations of cardiac troponin have a strong association with an adverse prognosis in patients with acute coronary syndromes and are used to identify patients who are likely to benefit from an early invasive management strategy.
2
–
4
High-sensitivity assays that allow the measurement of very low cardiac troponin levels in patients with stable heart disease are now available for clinical and research use. These low, previously undetectable troponin concentrations have shown strong associations with myocardial infarction, stroke, and death in a variety of primary and secondary prevention populations, including in . . .</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angioplasty</subject><subject>Biomarkers - blood</subject><subject>Calcium-binding protein</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cerebral infarction</subject><subject>Coronary artery disease</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Fees & charges</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Grants</subject><subject>Health risk assessment</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Kaplan-Meier Estimate</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - complications</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Troponin</subject><subject>Troponin T</subject><subject>Troponin T - blood</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcFP2zAUhy0EogV25DpFQpO4hMV2bMcXpKntRhFjh7Gz9eK8gKskLnaKtP9-aQsVTAJfLPl9_vR7-hFySrMLmgn59XZ2_dMDzanQjO6RMRWcp3meyX0yzjJWpLnSfESOYlxkw6G5PiQjJplUkrExmd8Fv_Sd6xLoqmQCoXJgk9kTdn1MhtffPZQNJvNoH7B1NrlCCH0ydREh4ubP1EGJPcYTclBDE_HT831M_nyf3U2u0ptfP-aTbzepFVz3KVRUKVEC1mUh6oKWDDmyXKMa0grLtOYKeKllVQhJbVkjKKaB17JWDDjnx-Ry612uyhYrOyQN0JhlcC2Ev8aDM28nnXsw9_7J5JIpyfUgOH8WBP-4wtib1kWLTQMd-lU0VGU5F4yzNXr2H7rwq9AN6xlGqdZCiIJ_RG1cUlO1ptItZYOPMWC9i0wzs67SvKly4D-_3nNHv3Q3AF-2QNtG0-GifUf0D-T_o1w</recordid><startdate>20150813</startdate><enddate>20150813</enddate><creator>Everett, Brendan M</creator><creator>Brooks, Maria Mori</creator><creator>Vlachos, Helen E.A</creator><creator>Chaitman, Bernard R</creator><creator>Frye, Robert L</creator><creator>Bhatt, Deepak L</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150813</creationdate><title>Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes</title><author>Everett, Brendan M ; Brooks, Maria Mori ; Vlachos, Helen E.A ; Chaitman, Bernard R ; Frye, Robert L ; Bhatt, Deepak L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-ad1775baefb85f81b2e3e249e70025c29937a3b96d8561cbfea729a3f6f72a333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angioplasty</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Everett, Brendan M</au><au>Brooks, Maria Mori</au><au>Vlachos, Helen E.A</au><au>Chaitman, Bernard R</au><au>Frye, Robert L</au><au>Bhatt, Deepak L</au><aucorp>BARI 2D Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-08-13</date><risdate>2015</risdate><volume>373</volume><issue>7</issue><spage>610</spage><epage>620</epage><pages>610-620</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Among patients with diabetes and stable heart disease, those with troponin T levels of 14 ng per liter or more had a 5-year rate of cardiovascular death, MI, or stroke of 27%, versus 13% in those with lower levels, but received no benefit from prompt revascularization.
Cardiac troponin concentration is the preferred marker of myocardial necrosis.
1
Elevated concentrations of cardiac troponin have a strong association with an adverse prognosis in patients with acute coronary syndromes and are used to identify patients who are likely to benefit from an early invasive management strategy.
2
–
4
High-sensitivity assays that allow the measurement of very low cardiac troponin levels in patients with stable heart disease are now available for clinical and research use. These low, previously undetectable troponin concentrations have shown strong associations with myocardial infarction, stroke, and death in a variety of primary and secondary prevention populations, including in . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26267622</pmid><doi>10.1056/NEJMoa1415921</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2015-08, Vol.373 (7), p.610-620 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Acute coronary syndromes Aged Angioplasty Biomarkers - blood Calcium-binding protein Cardiology Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - mortality Cerebral infarction Coronary artery disease Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Fees & charges Female Follow-Up Studies Grants Health risk assessment Heart attacks Heart diseases Heart failure Humans Ischemia Kaplan-Meier Estimate Laboratories Male Middle Aged Mortality Myocardial infarction Myocardial Infarction - etiology Myocardial Ischemia - blood Myocardial Ischemia - complications Proteins Risk Factors Stroke Stroke - etiology Troponin Troponin T Troponin T - blood Womens health |
| title | Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes |
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