Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model

Huntington disease (HD) is a neurodegenerative disorder for which new treatments are urgently needed. Pridopidine is a new dopaminergic stabilizer, recently developed for the treatment of motor symptoms associated with HD. The therapeutic effect of pridopidine in patients with HD has been determined...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-11, Vol.19 (11), p.2540-2548
Hauptverfasser:	Squitieri, Ferdinando, Di Pardo, Alba, Favellato, Mariagrazia, Amico, Enrico, Maglione, Vittorio, Frati, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Apoptosis - drug effects BDNF Brain-Derived Neurotrophic Factor - metabolism Cell Line, Transformed Clinical trials Disease Models, Animal Dopamine Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Dopamine receptors Drug dosages Huntington disease Huntington Disease - drug therapy Huntington Disease - metabolism Huntington Disease - physiopathology Huntington's disease Huntingtons disease Hypotheses Mice Motor Activity - drug effects Motor task performance Neostriatum Nervous system Neurodegenerative diseases Neuroprotection Neuroprotective Agents - therapeutic use Neurotrophic factors Original Piperidines - therapeutic use pridopidine Proteins Sig‐1R Studies
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