TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients

TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients

[ABSTRACT] [Background] Thymic stromal lymphopoietin (TSLP) plays an important role in promoting tumor survival, by manipulating the immune response and angiogenesis. However, the clinical significance of TSLP in gastric cancer is unclear. [Methods] Immunohistochemistry was used to investigate TSLP...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:YONAGO ACTA MEDICA 2015-09, Vol.58 (3), p.137-143
Hauptverfasser: Watanabe, Joji, Saito, Hiroaki, Miyatani, Kozo, Ikeguchi, Masahide, Umekita, Yoshihisa
Format: Artikel
Sprache:eng
Schlagworte:
Original
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 143
container_issue 3
container_start_page 137
container_title YONAGO ACTA MEDICA
container_volume 58
creator Watanabe, Joji
Saito, Hiroaki
Miyatani, Kozo
Ikeguchi, Masahide
Umekita, Yoshihisa
description [ABSTRACT] [Background] Thymic stromal lymphopoietin (TSLP) plays an important role in promoting tumor survival, by manipulating the immune response and angiogenesis. However, the clinical significance of TSLP in gastric cancer is unclear. [Methods] Immunohistochemistry was used to investigate TSLP expression in non-cancerous gastric mucosa and gastric cancer tissue from patients with gastric cancer. Serum TSLP levels were measured using an enzyme-linked immunosorbent assay. [Results] Tumors with TSLP expression were significantly larger than those without TSLP expression. TSLP expression was observed more frequently in advanced (T2/T3/T4) than in early (T1) gastric cancer and in stage 3/4 than in stage 1/2. Lymph node metastasis, liver metastasis, positive peritoneal lavage cytology, lymphatic invasion, and vascular invasion occurred significantly more often in TSLP-expressing than in non-expressing tumors. The prognosis of patients with TSLP-positive tumors was significantly worse than that of patients with TSLP-negative tumors. Patients with high serum TSLP concentrations also had a significantly worse prognosis than those with low concentrations. Multivariate analysis identified serum TSLP level as an independent prognostic indicator. [Conclusion] TSLP is closely related to the progression of gastric cancer and may predict survival in these patients.
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4626360</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1731782586</sourcerecordid><originalsourceid>FETCH-LOGICAL-j398t-f0b8a300d58ea2b2b73552b791090d0219c4b0d3a5195c281396a9a2cbd0f6003</originalsourceid><addsrcrecordid>eNpVkEFLJDEUhBtR1lH3L0iOe2l4yeuk0xdBBncUBhxQr4bX3ZkxQ08ym3SL_nvj6i56qTp8RRXUQTHjWKlSQ9UcFjOQHEtZczguTlLaAlQoQf0ojoWSqDXArHi8v1uu2NXLPtqUXPCMfM-u3eaJ3dk47dhfvLTPdmA3vncdjZYRW4UQ2SqGjQ_JJeY8W1Aao-vYnHxnM6PRWT-ms-JoTUOyPz_9tHj4fXU_vy6Xt4ub-eWy3GKjx3INrSYE6KW2JFrR1ihl1oZDAz0I3nRVCz2S5I3shObYKGpIdG0PawWAp8XFR-9-ane27_J2pMHso9tRfDWBnPlOvHsym_BsKiUUqveCX58FMfyZbBrNzqXODgN5G6ZkeI281kJqlaPnX7f-j_w7NQcWH4FM82ND8IPz1mzDFH0-wfROvAZPGyOASwMgNWC22gDHd6lQaMxI4RvxXonW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1731782586</pqid></control><display><type>article</type><title>TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients</title><source>Freely Accessible Japanese Titles</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Watanabe, Joji ; Saito, Hiroaki ; Miyatani, Kozo ; Ikeguchi, Masahide ; Umekita, Yoshihisa</creator><creatorcontrib>Watanabe, Joji ; Saito, Hiroaki ; Miyatani, Kozo ; Ikeguchi, Masahide ; Umekita, Yoshihisa ; School of Medicine ; Department of Pathology ; Division of Organ Pathology ; Department of Surgery ; Division of Surgical Oncology ; Tottori University Faculty of Medicine</creatorcontrib><description>[ABSTRACT] [Background] Thymic stromal lymphopoietin (TSLP) plays an important role in promoting tumor survival, by manipulating the immune response and angiogenesis. However, the clinical significance of TSLP in gastric cancer is unclear. [Methods] Immunohistochemistry was used to investigate TSLP expression in non-cancerous gastric mucosa and gastric cancer tissue from patients with gastric cancer. Serum TSLP levels were measured using an enzyme-linked immunosorbent assay. [Results] Tumors with TSLP expression were significantly larger than those without TSLP expression. TSLP expression was observed more frequently in advanced (T2/T3/T4) than in early (T1) gastric cancer and in stage 3/4 than in stage 1/2. Lymph node metastasis, liver metastasis, positive peritoneal lavage cytology, lymphatic invasion, and vascular invasion occurred significantly more often in TSLP-expressing than in non-expressing tumors. The prognosis of patients with TSLP-positive tumors was significantly worse than that of patients with TSLP-negative tumors. Patients with high serum TSLP concentrations also had a significantly worse prognosis than those with low concentrations. Multivariate analysis identified serum TSLP level as an independent prognostic indicator. [Conclusion] TSLP is closely related to the progression of gastric cancer and may predict survival in these patients.</description><identifier>ISSN: 0513-5710</identifier><identifier>EISSN: 1346-8049</identifier><identifier>PMID: 26538800</identifier><language>eng</language><publisher>Japan: Tottori University Faculty of Medicine</publisher><subject>Original</subject><ispartof>YONAGO ACTA MEDICA, 2015-09, Vol.58 (3), p.137-143</ispartof><rights>2015 Yonago Acta medica 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626360/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626360/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26538800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Joji</creatorcontrib><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Miyatani, Kozo</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>Department of Pathology</creatorcontrib><creatorcontrib>Division of Organ Pathology</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Division of Surgical Oncology</creatorcontrib><creatorcontrib>Tottori University Faculty of Medicine</creatorcontrib><title>TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients</title><title>YONAGO ACTA MEDICA</title><addtitle>Yonago Acta Med</addtitle><description>[ABSTRACT] [Background] Thymic stromal lymphopoietin (TSLP) plays an important role in promoting tumor survival, by manipulating the immune response and angiogenesis. However, the clinical significance of TSLP in gastric cancer is unclear. [Methods] Immunohistochemistry was used to investigate TSLP expression in non-cancerous gastric mucosa and gastric cancer tissue from patients with gastric cancer. Serum TSLP levels were measured using an enzyme-linked immunosorbent assay. [Results] Tumors with TSLP expression were significantly larger than those without TSLP expression. TSLP expression was observed more frequently in advanced (T2/T3/T4) than in early (T1) gastric cancer and in stage 3/4 than in stage 1/2. Lymph node metastasis, liver metastasis, positive peritoneal lavage cytology, lymphatic invasion, and vascular invasion occurred significantly more often in TSLP-expressing than in non-expressing tumors. The prognosis of patients with TSLP-positive tumors was significantly worse than that of patients with TSLP-negative tumors. Patients with high serum TSLP concentrations also had a significantly worse prognosis than those with low concentrations. Multivariate analysis identified serum TSLP level as an independent prognostic indicator. [Conclusion] TSLP is closely related to the progression of gastric cancer and may predict survival in these patients.</description><subject>Original</subject><issn>0513-5710</issn><issn>1346-8049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVkEFLJDEUhBtR1lH3L0iOe2l4yeuk0xdBBncUBhxQr4bX3ZkxQ08ym3SL_nvj6i56qTp8RRXUQTHjWKlSQ9UcFjOQHEtZczguTlLaAlQoQf0ojoWSqDXArHi8v1uu2NXLPtqUXPCMfM-u3eaJ3dk47dhfvLTPdmA3vncdjZYRW4UQ2SqGjQ_JJeY8W1Aao-vYnHxnM6PRWT-ms-JoTUOyPz_9tHj4fXU_vy6Xt4ub-eWy3GKjx3INrSYE6KW2JFrR1ihl1oZDAz0I3nRVCz2S5I3shObYKGpIdG0PawWAp8XFR-9-ane27_J2pMHso9tRfDWBnPlOvHsym_BsKiUUqveCX58FMfyZbBrNzqXODgN5G6ZkeI281kJqlaPnX7f-j_w7NQcWH4FM82ND8IPz1mzDFH0-wfROvAZPGyOASwMgNWC22gDHd6lQaMxI4RvxXonW</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Watanabe, Joji</creator><creator>Saito, Hiroaki</creator><creator>Miyatani, Kozo</creator><creator>Ikeguchi, Masahide</creator><creator>Umekita, Yoshihisa</creator><general>Tottori University Faculty of Medicine</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150901</creationdate><title>TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients</title><author>Watanabe, Joji ; Saito, Hiroaki ; Miyatani, Kozo ; Ikeguchi, Masahide ; Umekita, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j398t-f0b8a300d58ea2b2b73552b791090d0219c4b0d3a5195c281396a9a2cbd0f6003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Joji</creatorcontrib><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Miyatani, Kozo</creatorcontrib><creatorcontrib>Ikeguchi, Masahide</creatorcontrib><creatorcontrib>Umekita, Yoshihisa</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>Department of Pathology</creatorcontrib><creatorcontrib>Division of Organ Pathology</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Division of Surgical Oncology</creatorcontrib><creatorcontrib>Tottori University Faculty of Medicine</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>YONAGO ACTA MEDICA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Joji</au><au>Saito, Hiroaki</au><au>Miyatani, Kozo</au><au>Ikeguchi, Masahide</au><au>Umekita, Yoshihisa</au><aucorp>School of Medicine</aucorp><aucorp>Department of Pathology</aucorp><aucorp>Division of Organ Pathology</aucorp><aucorp>Department of Surgery</aucorp><aucorp>Division of Surgical Oncology</aucorp><aucorp>Tottori University Faculty of Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients</atitle><jtitle>YONAGO ACTA MEDICA</jtitle><addtitle>Yonago Acta Med</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>58</volume><issue>3</issue><spage>137</spage><epage>143</epage><pages>137-143</pages><issn>0513-5710</issn><eissn>1346-8049</eissn><abstract>[ABSTRACT] [Background] Thymic stromal lymphopoietin (TSLP) plays an important role in promoting tumor survival, by manipulating the immune response and angiogenesis. However, the clinical significance of TSLP in gastric cancer is unclear. [Methods] Immunohistochemistry was used to investigate TSLP expression in non-cancerous gastric mucosa and gastric cancer tissue from patients with gastric cancer. Serum TSLP levels were measured using an enzyme-linked immunosorbent assay. [Results] Tumors with TSLP expression were significantly larger than those without TSLP expression. TSLP expression was observed more frequently in advanced (T2/T3/T4) than in early (T1) gastric cancer and in stage 3/4 than in stage 1/2. Lymph node metastasis, liver metastasis, positive peritoneal lavage cytology, lymphatic invasion, and vascular invasion occurred significantly more often in TSLP-expressing than in non-expressing tumors. The prognosis of patients with TSLP-positive tumors was significantly worse than that of patients with TSLP-negative tumors. Patients with high serum TSLP concentrations also had a significantly worse prognosis than those with low concentrations. Multivariate analysis identified serum TSLP level as an independent prognostic indicator. [Conclusion] TSLP is closely related to the progression of gastric cancer and may predict survival in these patients.</abstract><cop>Japan</cop><pub>Tottori University Faculty of Medicine</pub><pmid>26538800</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0513-5710
ispartof YONAGO ACTA MEDICA, 2015-09, Vol.58 (3), p.137-143
issn 0513-5710
1346-8049
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4626360
source Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Original
title TSLP Expression and High Serum TSLP Level Indicate a Poor Prognosis in Gastric Cancer Patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T09%3A47%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TSLP%20Expression%20and%20High%20Serum%20TSLP%20Level%20Indicate%20a%20Poor%20Prognosis%20in%20Gastric%20Cancer%20Patients&rft.jtitle=YONAGO%20ACTA%20MEDICA&rft.au=Watanabe,%20Joji&rft.aucorp=School%20of%20Medicine&rft.date=2015-09-01&rft.volume=58&rft.issue=3&rft.spage=137&rft.epage=143&rft.pages=137-143&rft.issn=0513-5710&rft.eissn=1346-8049&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1731782586%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1731782586&rft_id=info:pmid/26538800&rfr_iscdi=true