AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation of double-strand DNA breaks (DSBs) and their error-prone repair. Here we show that DSBs occur at a high frequency in unrearranged (germline) Ig variable (V) genes, BCL6 and c-MYC. These DSBs are blunt, target...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2003-06, Vol.18 (6), p.727-738
Hauptverfasser:	Zan, Hong, Wu, Xiaoping, Komori, Atsumasa, Holloman, William K., Casali, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - metabolism DNA repair DNA-Binding Proteins - metabolism Genes Humans Immune system Mutation Rad51 Recombinase Somatic Hypermutation, Immunoglobulin T-Lymphocytes - metabolism
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