Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders
Background Gastrointestinal infections are risk factors for irritable bowel syndrome (IBS) and functional dyspepsia (FD). We investigated whether non‐enteric infections and antibiotic exposure are also associated with the development of functional gastrointestinal disorders (FGIDs). Methods In a nes...
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| Veröffentlicht in: | Neurogastroenterology and motility 2015-11, Vol.27 (11), p.1580-1586 |
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| creator | Paula, H. Grover, M. Halder, S. L. Locke, G. R. Schleck, C. D. Zinsmeister, A. R. Talley, N. J. |
| description | Background
Gastrointestinal infections are risk factors for irritable bowel syndrome (IBS) and functional dyspepsia (FD). We investigated whether non‐enteric infections and antibiotic exposure are also associated with the development of functional gastrointestinal disorders (FGIDs).
Methods
In a nested case–control study, random samples of Olmsted County, MN, were mailed valid self‐report questionnaires from 1988 through 1994, and then follow‐up questionnaires from 1995 through 2003. Survey responders who did not report any FGID symptoms at baseline, but then reported such symptoms in at least one subsequent survey, were classified as new‐onset cases. Age‐matched controls were individuals who did not have symptoms at either the initial or subsequent surveys.
Key Results
The overall response rate was 78% to the initial survey and 52% to the follow‐up survey. Based on the responses, 316 participants had a new onset of an FGID (43 IBS constipation, 95 IBS diarrhea, 25 IBS mixed, and 153 other FGIDs, including FD) and 250 did not (controls). Around 76% (241/316) of cases reported a non‐enteric infection vs 66% (166/250) of the controls. The frequency of enteric infections was similar between the two groups. Of the new FGID cases, 83% had a non‐enteric infection that was treated with antibiotic. In a logistic regression model, treatment with antibiotics for a non‐gastrointestinal infection was associated with the development of an FGID (odds ratio = 1.90; 95% CI: 1.21–2.98; p = 0.005), after adjusting for age and sex.
Conclusions & Inferences
Based on a case–control study, treatment of a non‐gastrointestinal infection with antibiotics appears to be a risk factor for development of an FGID.
Gastrointestinal infections have been associated with the development of functional gastrointestinal disorders (FGIDs). Our aim was to determine if non‐gastrointestinal infections are also associated with the development of FGIDs. In a nested case–control study with residents of Olmsted County, MN, antibiotic‐treated non‐gastrointestinal infections were associated with an increased risk of development of FGIDs. |
| doi_str_mv | 10.1111/nmo.12655 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4624515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3847626401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5135-627db954766b2a1fe8208e0336f257f6f1d4c5deb25266d991fed322d5dd47993</originalsourceid><addsrcrecordid>eNp1kc9O3DAQxi3UioWFAy9QReoFpAZsJ3Y2l0rVqv8kChc4W05sb70k9mInoL31EXhGnqSTzXZFkbBk2WP_5vM3HoROCD4nMC5c688J5YztoQOScZbSckbfDXuGU1JSNkGHMS4xxpzmfB9NKM9wlhF8gJZX3j3_edKu08HWiXVG1531Ln5KpOtsZX0Hx33UQ6ySYONd4k2i9INu_KqFvCE0vdtkySZZyNgFb0EvdnY4UDb6oHSIR-i9kU3Ux9t1im6_fb2Z_0gvr7__nH-5TGsGhlNOC1WVLC84r6gkRs8onmmwyw1lheGGqLxmSleUUc5VWQKiMkoVUyovyjKbos-j7qqvWq1q8BhkI1bBtjKshZdW_H_j7G-x8A8ih99hhIHA6VYg-Pse6hCtjbVuGum076MgBR3emeU5oB9foUvfByh7pDKewwTqbKTq4GMM2uzMECyGDgrooNh0ENgPL93vyH8tA-BiBB5to9dvK4mrX9ej5F8TnKg4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1727364736</pqid></control><display><type>article</type><title>Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Paula, H. ; Grover, M. ; Halder, S. L. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Talley, N. J.</creator><creatorcontrib>Paula, H. ; Grover, M. ; Halder, S. L. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Talley, N. J.</creatorcontrib><description>Background
Gastrointestinal infections are risk factors for irritable bowel syndrome (IBS) and functional dyspepsia (FD). We investigated whether non‐enteric infections and antibiotic exposure are also associated with the development of functional gastrointestinal disorders (FGIDs).
Methods
In a nested case–control study, random samples of Olmsted County, MN, were mailed valid self‐report questionnaires from 1988 through 1994, and then follow‐up questionnaires from 1995 through 2003. Survey responders who did not report any FGID symptoms at baseline, but then reported such symptoms in at least one subsequent survey, were classified as new‐onset cases. Age‐matched controls were individuals who did not have symptoms at either the initial or subsequent surveys.
Key Results
The overall response rate was 78% to the initial survey and 52% to the follow‐up survey. Based on the responses, 316 participants had a new onset of an FGID (43 IBS constipation, 95 IBS diarrhea, 25 IBS mixed, and 153 other FGIDs, including FD) and 250 did not (controls). Around 76% (241/316) of cases reported a non‐enteric infection vs 66% (166/250) of the controls. The frequency of enteric infections was similar between the two groups. Of the new FGID cases, 83% had a non‐enteric infection that was treated with antibiotic. In a logistic regression model, treatment with antibiotics for a non‐gastrointestinal infection was associated with the development of an FGID (odds ratio = 1.90; 95% CI: 1.21–2.98; p = 0.005), after adjusting for age and sex.
Conclusions & Inferences
Based on a case–control study, treatment of a non‐gastrointestinal infection with antibiotics appears to be a risk factor for development of an FGID.
Gastrointestinal infections have been associated with the development of functional gastrointestinal disorders (FGIDs). Our aim was to determine if non‐gastrointestinal infections are also associated with the development of FGIDs. In a nested case–control study with residents of Olmsted County, MN, antibiotic‐treated non‐gastrointestinal infections were associated with an increased risk of development of FGIDs.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.12655</identifier><identifier>PMID: 26303310</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age Distribution ; Aged ; Anti-Bacterial Agents - adverse effects ; antibiotics ; Case-Control Studies ; Female ; functional GI disorders ; Gastrointestinal Diseases - epidemiology ; Humans ; Infection - drug therapy ; Infection - epidemiology ; irritable bowel syndrome ; Male ; Middle Aged ; non‐enteric infections ; Odds Ratio ; Risk Factors ; Sex Distribution ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Neurogastroenterology and motility, 2015-11, Vol.27 (11), p.1580-1586</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5135-627db954766b2a1fe8208e0336f257f6f1d4c5deb25266d991fed322d5dd47993</citedby><cites>FETCH-LOGICAL-c5135-627db954766b2a1fe8208e0336f257f6f1d4c5deb25266d991fed322d5dd47993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.12655$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.12655$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26303310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paula, H.</creatorcontrib><creatorcontrib>Grover, M.</creatorcontrib><creatorcontrib>Halder, S. L.</creatorcontrib><creatorcontrib>Locke, G. R.</creatorcontrib><creatorcontrib>Schleck, C. D.</creatorcontrib><creatorcontrib>Zinsmeister, A. R.</creatorcontrib><creatorcontrib>Talley, N. J.</creatorcontrib><title>Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Gastrointestinal infections are risk factors for irritable bowel syndrome (IBS) and functional dyspepsia (FD). We investigated whether non‐enteric infections and antibiotic exposure are also associated with the development of functional gastrointestinal disorders (FGIDs).
Methods
In a nested case–control study, random samples of Olmsted County, MN, were mailed valid self‐report questionnaires from 1988 through 1994, and then follow‐up questionnaires from 1995 through 2003. Survey responders who did not report any FGID symptoms at baseline, but then reported such symptoms in at least one subsequent survey, were classified as new‐onset cases. Age‐matched controls were individuals who did not have symptoms at either the initial or subsequent surveys.
Key Results
The overall response rate was 78% to the initial survey and 52% to the follow‐up survey. Based on the responses, 316 participants had a new onset of an FGID (43 IBS constipation, 95 IBS diarrhea, 25 IBS mixed, and 153 other FGIDs, including FD) and 250 did not (controls). Around 76% (241/316) of cases reported a non‐enteric infection vs 66% (166/250) of the controls. The frequency of enteric infections was similar between the two groups. Of the new FGID cases, 83% had a non‐enteric infection that was treated with antibiotic. In a logistic regression model, treatment with antibiotics for a non‐gastrointestinal infection was associated with the development of an FGID (odds ratio = 1.90; 95% CI: 1.21–2.98; p = 0.005), after adjusting for age and sex.
Conclusions & Inferences
Based on a case–control study, treatment of a non‐gastrointestinal infection with antibiotics appears to be a risk factor for development of an FGID.
Gastrointestinal infections have been associated with the development of functional gastrointestinal disorders (FGIDs). Our aim was to determine if non‐gastrointestinal infections are also associated with the development of FGIDs. In a nested case–control study with residents of Olmsted County, MN, antibiotic‐treated non‐gastrointestinal infections were associated with an increased risk of development of FGIDs.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>antibiotics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>functional GI disorders</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Humans</subject><subject>Infection - drug therapy</subject><subject>Infection - epidemiology</subject><subject>irritable bowel syndrome</subject><subject>Male</subject><subject>Middle Aged</subject><subject>non‐enteric infections</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9O3DAQxi3UioWFAy9QReoFpAZsJ3Y2l0rVqv8kChc4W05sb70k9mInoL31EXhGnqSTzXZFkbBk2WP_5vM3HoROCD4nMC5c688J5YztoQOScZbSckbfDXuGU1JSNkGHMS4xxpzmfB9NKM9wlhF8gJZX3j3_edKu08HWiXVG1531Ln5KpOtsZX0Hx33UQ6ySYONd4k2i9INu_KqFvCE0vdtkySZZyNgFb0EvdnY4UDb6oHSIR-i9kU3Ux9t1im6_fb2Z_0gvr7__nH-5TGsGhlNOC1WVLC84r6gkRs8onmmwyw1lheGGqLxmSleUUc5VWQKiMkoVUyovyjKbos-j7qqvWq1q8BhkI1bBtjKshZdW_H_j7G-x8A8ih99hhIHA6VYg-Pse6hCtjbVuGum076MgBR3emeU5oB9foUvfByh7pDKewwTqbKTq4GMM2uzMECyGDgrooNh0ENgPL93vyH8tA-BiBB5to9dvK4mrX9ej5F8TnKg4</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Paula, H.</creator><creator>Grover, M.</creator><creator>Halder, S. L.</creator><creator>Locke, G. R.</creator><creator>Schleck, C. D.</creator><creator>Zinsmeister, A. R.</creator><creator>Talley, N. J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201511</creationdate><title>Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders</title><author>Paula, H. ; Grover, M. ; Halder, S. L. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Talley, N. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5135-627db954766b2a1fe8208e0336f257f6f1d4c5deb25266d991fed322d5dd47993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>antibiotics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>functional GI disorders</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Humans</topic><topic>Infection - drug therapy</topic><topic>Infection - epidemiology</topic><topic>irritable bowel syndrome</topic><topic>Male</topic><topic>Middle Aged</topic><topic>non‐enteric infections</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paula, H.</creatorcontrib><creatorcontrib>Grover, M.</creatorcontrib><creatorcontrib>Halder, S. L.</creatorcontrib><creatorcontrib>Locke, G. R.</creatorcontrib><creatorcontrib>Schleck, C. D.</creatorcontrib><creatorcontrib>Zinsmeister, A. R.</creatorcontrib><creatorcontrib>Talley, N. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paula, H.</au><au>Grover, M.</au><au>Halder, S. L.</au><au>Locke, G. R.</au><au>Schleck, C. D.</au><au>Zinsmeister, A. R.</au><au>Talley, N. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2015-11</date><risdate>2015</risdate><volume>27</volume><issue>11</issue><spage>1580</spage><epage>1586</epage><pages>1580-1586</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Gastrointestinal infections are risk factors for irritable bowel syndrome (IBS) and functional dyspepsia (FD). We investigated whether non‐enteric infections and antibiotic exposure are also associated with the development of functional gastrointestinal disorders (FGIDs).
Methods
In a nested case–control study, random samples of Olmsted County, MN, were mailed valid self‐report questionnaires from 1988 through 1994, and then follow‐up questionnaires from 1995 through 2003. Survey responders who did not report any FGID symptoms at baseline, but then reported such symptoms in at least one subsequent survey, were classified as new‐onset cases. Age‐matched controls were individuals who did not have symptoms at either the initial or subsequent surveys.
Key Results
The overall response rate was 78% to the initial survey and 52% to the follow‐up survey. Based on the responses, 316 participants had a new onset of an FGID (43 IBS constipation, 95 IBS diarrhea, 25 IBS mixed, and 153 other FGIDs, including FD) and 250 did not (controls). Around 76% (241/316) of cases reported a non‐enteric infection vs 66% (166/250) of the controls. The frequency of enteric infections was similar between the two groups. Of the new FGID cases, 83% had a non‐enteric infection that was treated with antibiotic. In a logistic regression model, treatment with antibiotics for a non‐gastrointestinal infection was associated with the development of an FGID (odds ratio = 1.90; 95% CI: 1.21–2.98; p = 0.005), after adjusting for age and sex.
Conclusions & Inferences
Based on a case–control study, treatment of a non‐gastrointestinal infection with antibiotics appears to be a risk factor for development of an FGID.
Gastrointestinal infections have been associated with the development of functional gastrointestinal disorders (FGIDs). Our aim was to determine if non‐gastrointestinal infections are also associated with the development of FGIDs. In a nested case–control study with residents of Olmsted County, MN, antibiotic‐treated non‐gastrointestinal infections were associated with an increased risk of development of FGIDs.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26303310</pmid><doi>10.1111/nmo.12655</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Age Distribution Aged Anti-Bacterial Agents - adverse effects antibiotics Case-Control Studies Female functional GI disorders Gastrointestinal Diseases - epidemiology Humans Infection - drug therapy Infection - epidemiology irritable bowel syndrome Male Middle Aged non‐enteric infections Odds Ratio Risk Factors Sex Distribution Surveys and Questionnaires Young Adult |
| title | Non‐enteric infections, antibiotic use, and risk of development of functional gastrointestinal disorders |
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