5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Using a combination of different approaches, the authors demonstrate that serotonin 1A receptors expressed in mature dentate gyrus granule...

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Veröffentlicht in:	Nature neuroscience 2015-11, Vol.18 (11), p.1606-1616
Hauptverfasser:	Samuels, Benjamin Adam, Anacker, Christoph, Hu, Alice, Levinstein, Marjorie R, Pickenhagen, Anouchka, Tsetsenis, Theodore, Madroñal, Noelia, Donaldson, Zoe R, Drew, Liam John, Dranovsky, Alex, Gross, Cornelius T, Tanaka, Kenji F, Hen, René
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/1300 631/378/1689/1414 631/378/368/2430 631/378/368/2431 Animal Genetics and Genomics Animals Antidepressants Antidepressive Agents, Second-Generation - pharmacology Anxiety Behavior Behavioral Sciences Biological Techniques Biomedicine Brain Care and treatment Cytoplasmic Granules - drug effects Dentate gyrus Dentate Gyrus - drug effects Depression, Mental Fluoxetine - pharmacology Mental depression Mice, Transgenic Neurobiology Neurogenesis Neurogenesis - drug effects Neurons - drug effects Neurosciences Physiological aspects Receptor, Serotonin, 5-HT1A - metabolism Receptors Serotonin
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