Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)
Toll-like receptors (TLRs) and nucleotide binding and oligomerization domain (NOD) receptors are pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and play crucial role in innate immunity. In addition to PAMPs, PRRs recognize endogenous molecules rele...
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| description | Toll-like receptors (TLRs) and nucleotide binding and oligomerization domain (NOD) receptors are pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and play crucial role in innate immunity. In addition to PAMPs, PRRs recognize endogenous molecules released from damaged tissue or dead cells [damage-associated molecular patterns (DAMPs)] and activate signaling cascades to induce inflammatory processes. In the aquatic environment, large variation in seasonal and diurnal water temperature causes heat and cold stresses in fish, resulting in tissue injury and mortality of fish. In the Indian subcontinent, catla (
Catla catla
) is an economically important freshwater fish species and is prone to thermal stresses. To investigate the response of pattern recognition receptors in thermal stress, we analyzed TLRs (TLR2, TLR4 and TLR5) and NOD (NOD1 and NOD2) receptors gene expression in catla following heat and cold stress. Analysis of tissue samples (gill, liver, kidney and blood) of the thermal stressed and control fish by quantitative real-time PCR (qRT-PCR) assay revealed significant (
p
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| doi_str_mv | 10.1007/s13205-015-0306-5 |
| format | Article |
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Catla catla
) is an economically important freshwater fish species and is prone to thermal stresses. To investigate the response of pattern recognition receptors in thermal stress, we analyzed TLRs (TLR2, TLR4 and TLR5) and NOD (NOD1 and NOD2) receptors gene expression in catla following heat and cold stress. Analysis of tissue samples (gill, liver, kidney and blood) of the thermal stressed and control fish by quantitative real-time PCR (qRT-PCR) assay revealed significant (
p
< 0.05) induction of TLR2, TLR4 and NOD2 gene expression in majority of the tested tissues of the treated fish as compared to the control. The expression of TLR5 and NOD1 gene was also induced in the heat and cold stressed fish, but mostly restricted in the blood. The downstream signaling molecule of TLR and NOD signaling pathway viz., MyD88 (myeloid differentiation primary response gene 88) and RICK (receptor interacting serine-threonine protein kinase-2) was also induced in the thermal stressed fish suggesting the engagement of TLR and NOD signaling pathway during thermal stress.</description><identifier>ISSN: 2190-572X</identifier><identifier>EISSN: 2190-5738</identifier><identifier>DOI: 10.1007/s13205-015-0306-5</identifier><identifier>PMID: 28324409</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Agriculture ; aquatic environment ; Bioinformatics ; Biomaterials ; Biotechnology ; blood ; Cancer Research ; carp ; Catla catla ; Chemistry ; Chemistry and Materials Science ; Cold ; cold stress ; freshwater fish ; Gene expression ; genes ; gills ; Heat ; innate immunity ; intracellular signaling peptides and proteins ; kidneys ; Kinases ; Ligands ; liver ; mortality ; oligomerization ; Original ; Original Article ; pathogen-associated molecular patterns ; Pathogens ; Pattern recognition ; Proteins ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; signal transduction ; Stem Cells ; Toll-like receptor 2 ; Toll-like receptor 4 ; Toll-like receptor 5 ; Water temperature</subject><ispartof>3 Biotech, 2015-12, Vol.5 (6), p.1021-1030</ispartof><rights>The Author(s) 2015</rights><rights>King Abdulaziz City for Science and Technology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-443f5a731e364ba84a700b42529b4b2a9d075f96cd34767cbed76e3878e5dba13</citedby><cites>FETCH-LOGICAL-c536t-443f5a731e364ba84a700b42529b4b2a9d075f96cd34767cbed76e3878e5dba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624144/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624144/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28324409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basu, Madhubanti</creatorcontrib><creatorcontrib>Paichha, Mahismita</creatorcontrib><creatorcontrib>Swain, Banikalyan</creatorcontrib><creatorcontrib>Lenka, Saswati S.</creatorcontrib><creatorcontrib>Singh, Samarpal</creatorcontrib><creatorcontrib>Chakrabarti, Rina</creatorcontrib><creatorcontrib>Samanta, Mrinal</creatorcontrib><title>Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)</title><title>3 Biotech</title><addtitle>3 Biotech</addtitle><addtitle>3 Biotech</addtitle><description>Toll-like receptors (TLRs) and nucleotide binding and oligomerization domain (NOD) receptors are pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and play crucial role in innate immunity. In addition to PAMPs, PRRs recognize endogenous molecules released from damaged tissue or dead cells [damage-associated molecular patterns (DAMPs)] and activate signaling cascades to induce inflammatory processes. In the aquatic environment, large variation in seasonal and diurnal water temperature causes heat and cold stresses in fish, resulting in tissue injury and mortality of fish. In the Indian subcontinent, catla (
Catla catla
) is an economically important freshwater fish species and is prone to thermal stresses. To investigate the response of pattern recognition receptors in thermal stress, we analyzed TLRs (TLR2, TLR4 and TLR5) and NOD (NOD1 and NOD2) receptors gene expression in catla following heat and cold stress. Analysis of tissue samples (gill, liver, kidney and blood) of the thermal stressed and control fish by quantitative real-time PCR (qRT-PCR) assay revealed significant (
p
< 0.05) induction of TLR2, TLR4 and NOD2 gene expression in majority of the tested tissues of the treated fish as compared to the control. The expression of TLR5 and NOD1 gene was also induced in the heat and cold stressed fish, but mostly restricted in the blood. The downstream signaling molecule of TLR and NOD signaling pathway viz., MyD88 (myeloid differentiation primary response gene 88) and RICK (receptor interacting serine-threonine protein kinase-2) was also induced in the thermal stressed fish suggesting the engagement of TLR and NOD signaling pathway during thermal stress.</description><subject>Agriculture</subject><subject>aquatic environment</subject><subject>Bioinformatics</subject><subject>Biomaterials</subject><subject>Biotechnology</subject><subject>blood</subject><subject>Cancer Research</subject><subject>carp</subject><subject>Catla catla</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cold</subject><subject>cold stress</subject><subject>freshwater fish</subject><subject>Gene expression</subject><subject>genes</subject><subject>gills</subject><subject>Heat</subject><subject>innate immunity</subject><subject>intracellular signaling peptides and proteins</subject><subject>kidneys</subject><subject>Kinases</subject><subject>Ligands</subject><subject>liver</subject><subject>mortality</subject><subject>oligomerization</subject><subject>Original</subject><subject>Original Article</subject><subject>pathogen-associated molecular patterns</subject><subject>Pathogens</subject><subject>Pattern recognition</subject><subject>Proteins</subject><subject>quantitative polymerase chain reaction</subject><subject>reverse transcriptase polymerase chain reaction</subject><subject>signal transduction</subject><subject>Stem Cells</subject><subject>Toll-like receptor 2</subject><subject>Toll-like receptor 4</subject><subject>Toll-like receptor 5</subject><subject>Water temperature</subject><issn>2190-572X</issn><issn>2190-5738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkluL1TAQx4so7nLcD-CLBHxZYau5Nu2LIMfbwtEFWcG3kLbTbg5p0k1aV7-Yn8_0nPWwCrKBTC7zmxmS-WfZU4JfEozlq0gYxSLHJE2Gi1w8yI4pqXAuJCsfHvb021F2EuMWpyGIqAh-nB3RklHOcXWc_frk29nqyXiHfIcuN1_o2WL5zooz9PniLUHatcuGogANjJMPqAcHCH6MAWJMsXGHTFdgAmr9jYtTAD2gaHqnrXE9GryFZrYQUeet9TfLXcLDoC1a4BiRccsNOnet0Q4NepvKNDqMyUxWo9P1btkdXjzJHnXaRji5XVfZ1_fvLtcf883Fh_P1m03eCFZMOeesE1oyAqzgtS65lhjXnApa1bymumqxFF1VNC3jspBNDa0sgJWyBNHWmrBV9nqfd5zrAdoG3BS0VWMwgw4_lddG_e1x5kr1_rviBeUklV9lp7cJgr-eIU5qMLEBa7UDP0dFMcUVSa1k96KkLDEueSXL-1HJUotlxaqEPv8H3fo5pK4sFC0YF7SgiSJ7qgk-xgDd4YkEq0Vuai83leSmFrkpkWKe3f2bQ8QfcSWA7oGYXK6HcKf0f7P-BpKA304</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Basu, Madhubanti</creator><creator>Paichha, Mahismita</creator><creator>Swain, Banikalyan</creator><creator>Lenka, Saswati S.</creator><creator>Singh, Samarpal</creator><creator>Chakrabarti, Rina</creator><creator>Samanta, Mrinal</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)</title><author>Basu, Madhubanti ; Paichha, Mahismita ; Swain, Banikalyan ; Lenka, Saswati S. ; Singh, Samarpal ; Chakrabarti, Rina ; Samanta, Mrinal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-443f5a731e364ba84a700b42529b4b2a9d075f96cd34767cbed76e3878e5dba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Agriculture</topic><topic>aquatic environment</topic><topic>Bioinformatics</topic><topic>Biomaterials</topic><topic>Biotechnology</topic><topic>blood</topic><topic>Cancer Research</topic><topic>carp</topic><topic>Catla catla</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cold</topic><topic>cold stress</topic><topic>freshwater fish</topic><topic>Gene expression</topic><topic>genes</topic><topic>gills</topic><topic>Heat</topic><topic>innate immunity</topic><topic>intracellular signaling peptides and proteins</topic><topic>kidneys</topic><topic>Kinases</topic><topic>Ligands</topic><topic>liver</topic><topic>mortality</topic><topic>oligomerization</topic><topic>Original</topic><topic>Original Article</topic><topic>pathogen-associated molecular patterns</topic><topic>Pathogens</topic><topic>Pattern recognition</topic><topic>Proteins</topic><topic>quantitative polymerase chain reaction</topic><topic>reverse transcriptase polymerase chain reaction</topic><topic>signal transduction</topic><topic>Stem Cells</topic><topic>Toll-like receptor 2</topic><topic>Toll-like receptor 4</topic><topic>Toll-like receptor 5</topic><topic>Water temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basu, Madhubanti</creatorcontrib><creatorcontrib>Paichha, Mahismita</creatorcontrib><creatorcontrib>Swain, Banikalyan</creatorcontrib><creatorcontrib>Lenka, Saswati S.</creatorcontrib><creatorcontrib>Singh, Samarpal</creatorcontrib><creatorcontrib>Chakrabarti, Rina</creatorcontrib><creatorcontrib>Samanta, Mrinal</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>3 Biotech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basu, Madhubanti</au><au>Paichha, Mahismita</au><au>Swain, Banikalyan</au><au>Lenka, Saswati S.</au><au>Singh, Samarpal</au><au>Chakrabarti, Rina</au><au>Samanta, Mrinal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)</atitle><jtitle>3 Biotech</jtitle><stitle>3 Biotech</stitle><addtitle>3 Biotech</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>5</volume><issue>6</issue><spage>1021</spage><epage>1030</epage><pages>1021-1030</pages><issn>2190-572X</issn><eissn>2190-5738</eissn><abstract>Toll-like receptors (TLRs) and nucleotide binding and oligomerization domain (NOD) receptors are pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and play crucial role in innate immunity. In addition to PAMPs, PRRs recognize endogenous molecules released from damaged tissue or dead cells [damage-associated molecular patterns (DAMPs)] and activate signaling cascades to induce inflammatory processes. In the aquatic environment, large variation in seasonal and diurnal water temperature causes heat and cold stresses in fish, resulting in tissue injury and mortality of fish. In the Indian subcontinent, catla (
Catla catla
) is an economically important freshwater fish species and is prone to thermal stresses. To investigate the response of pattern recognition receptors in thermal stress, we analyzed TLRs (TLR2, TLR4 and TLR5) and NOD (NOD1 and NOD2) receptors gene expression in catla following heat and cold stress. Analysis of tissue samples (gill, liver, kidney and blood) of the thermal stressed and control fish by quantitative real-time PCR (qRT-PCR) assay revealed significant (
p
< 0.05) induction of TLR2, TLR4 and NOD2 gene expression in majority of the tested tissues of the treated fish as compared to the control. The expression of TLR5 and NOD1 gene was also induced in the heat and cold stressed fish, but mostly restricted in the blood. The downstream signaling molecule of TLR and NOD signaling pathway viz., MyD88 (myeloid differentiation primary response gene 88) and RICK (receptor interacting serine-threonine protein kinase-2) was also induced in the thermal stressed fish suggesting the engagement of TLR and NOD signaling pathway during thermal stress.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28324409</pmid><doi>10.1007/s13205-015-0306-5</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Agriculture aquatic environment Bioinformatics Biomaterials Biotechnology blood Cancer Research carp Catla catla Chemistry Chemistry and Materials Science Cold cold stress freshwater fish Gene expression genes gills Heat innate immunity intracellular signaling peptides and proteins kidneys Kinases Ligands liver mortality oligomerization Original Original Article pathogen-associated molecular patterns Pathogens Pattern recognition Proteins quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction signal transduction Stem Cells Toll-like receptor 2 Toll-like receptor 4 Toll-like receptor 5 Water temperature |
| title | Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla) |
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