Galectins regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1

•Microbial neuraminidases unmask galectin ligands at the airway epithelial surface.•Galectin 1 and galectin 3 modulate the expression of SOCS1 and RIG1.•Galectins modulate the activation of ERK, AKT or JAK/STAT1 signaling pathways.•Leads to a disregulated expression and release of pro-inflammatory c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular immunology 2015-12, Vol.68 (2), p.194-202
Hauptverfasser:	Nita-Lazar, Mihai, Banerjee, Aditi, Feng, Chiguang, Vasta, Gerardo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Bacterial Proteins - pharmacology Cell Line, Tumor Chemokines Cytokines Cytokines - biosynthesis Cytokines - metabolism DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - pharmacology epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - immunology epithelium Escherichia coli - genetics Escherichia coli - metabolism Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - immunology Galectin Galectin 1 - biosynthesis Galectin 1 - immunology Galectin 1 - pharmacology Galectin 3 - biosynthesis Galectin 3 - immunology Galectin 3 - pharmacology Gene Expression Regulation Humans Inflammation influenza Influenza A virus Influenza A virus - immunology Janus Kinases - genetics Janus Kinases - immunology Mice mitogen-activated protein kinase mixed infection mortality Neuraminidase Neuraminidase - pharmacology patients pneumonia Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Receptors, Immunologic Recombinant Proteins - biosynthesis Recombinant Proteins - immunology Recombinant Proteins - pharmacology Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - immunology RIG1 secretion sepsis (infection) sialidase Signal Transduction Signaling pathway SOCS STAT1 Transcription Factor - genetics STAT1 Transcription Factor - immunology Streptococcus pneumoniae Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - immunology Suppressor of Cytokine Signaling Proteins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!