Ca2+and Mn2+Influx Through Receptor-Mediated Activation of Nonspecific Cation Channels in Mast Cells

Whole-cell patch-clamp recordings of membrane currents and Fura-2 measurements of free intracellular calcium concentration ([Ca2+]i) were used to study calcium influx through receptor-activated cation channels in rat peritoneal mast cells. Cation channels were activated by the secretagogue compound...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-04, Vol.90 (7), p.3068-3072
Hauptverfasser:	Fasolato, Cristina, Hoth, Markus, Matthews, Gary, Penner, Reinhold
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Biological and medical sciences Calcium Calcium - metabolism Calcium - pharmacology Cations Cell physiology Electric potential Fluorescence Fundamental and applied biological sciences. Psychology Fura-2 Heparin In Vitro Techniques Inositol 1,4,5-Trisphosphate - pharmacology Ion Channels - drug effects Ion Channels - physiology Ion currents Kinetics Manganese - metabolism Mast cells Mast Cells - drug effects Mast Cells - physiology Membrane and intracellular transports Membrane Potentials Molecular and cellular biology p-Methoxy-N-methylphenethylamine - pharmacology Patch clamp techniques Pipettes Rats Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Spectrometry, Fluorescence
Online-Zugang:	Volltext
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