Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants
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| Veröffentlicht in: | European journal of pediatrics 2015-11, Vol.174 (11), p.1511-1516 |
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| creator | Cabrerizo, María Trallero, Gloria Pena, María José Cilla, Amaia Megias, Gregoria Muñoz-Almagro, Carmen Del Amo, Eva Roda, Diana Mensalvas, Ana Isabel Moreno-Docón, Antonio García-Costa, Juan Rabella, Nuria Omeñaca, Manuel Romero, María Pilar Sanbonmatsu-Gámez, Sara Pérez-Ruiz, Mercedes Santos-Muñoz, María José Calvo, Cristina |
| description | Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants |
| doi_str_mv | 10.1007/s00431-015-2566-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4623089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1728258302</sourcerecordid><originalsourceid>FETCH-LOGICAL-c639t-427c344aa81a011008d1d005cb7c55ac7086e48ce34e0bdea943da2fe0e681ca3</originalsourceid><addsrcrecordid>eNqNks2KFDEUhQtRnHb0AdxIwI2bGm9-KpVsBGn8gwE3ug7p1K2uDFVJm1Q19HP4wqbodhgFwVUW5zsnNzenql5SuKEA7dsMIDitgTY1a6Ss9aNqQwVnNYVWPq42wAXUkmp9VT3L-Q6KR1P1tLpijVasiJvq5zZOB5t8joHEnuDBdzj5OMb9idjQETf64J0diRtssm7Ggs7e5RX2oUc3-xgy2Z3IsEw2kJKFbohHn5ZMjvmGzEPMuOoYivkidEvyYV80JL1PeSZTDPOwZo6-x-fVk96OGV9czuvq-8cP37af69uvn75s39_WTnI914K1jgthraIWaFmI6mgH0Lhd65rGuhaURKEccoGw69BqwTvLegSUijrLr6t359zDspuwc2XCZEdzSH6y6WSi9eZPJfjB7OPRCMk4KF0C3lwCUvyxYJ7N5LPDcbQB45INbYVUioOE_0CZYk1hWUFf_4XexSWFsomVahvNW71S9Ey5FHNO2N_PTcGs7TDndpjSDrO2w6zzvnr44HvH7zoUgJ2BfFg_CNODq_-Z-guKacjH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1727593792</pqid></control><display><type>article</type><title>Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Cabrerizo, María ; Trallero, Gloria ; Pena, María José ; Cilla, Amaia ; Megias, Gregoria ; Muñoz-Almagro, Carmen ; Del Amo, Eva ; Roda, Diana ; Mensalvas, Ana Isabel ; Moreno-Docón, Antonio ; García-Costa, Juan ; Rabella, Nuria ; Omeñaca, Manuel ; Romero, María Pilar ; Sanbonmatsu-Gámez, Sara ; Pérez-Ruiz, Mercedes ; Santos-Muñoz, María José ; Calvo, Cristina</creator><creatorcontrib>Cabrerizo, María ; Trallero, Gloria ; Pena, María José ; Cilla, Amaia ; Megias, Gregoria ; Muñoz-Almagro, Carmen ; Del Amo, Eva ; Roda, Diana ; Mensalvas, Ana Isabel ; Moreno-Docón, Antonio ; García-Costa, Juan ; Rabella, Nuria ; Omeñaca, Manuel ; Romero, María Pilar ; Sanbonmatsu-Gámez, Sara ; Pérez-Ruiz, Mercedes ; Santos-Muñoz, María José ; Calvo, Cristina ; study group of "Enterovirus and parechovirus infections in children under 3 years-old, Spain" PI12-00904 ; And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, Spain” PI12-00904</creatorcontrib><description>Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants
<
1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (
p
= 0.03) and meningitis (
p
= 0.001) were significantly more frequent in patients with EV infections than with HPeV.
Conclusions
: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
What is Known
:
•
Human parechovirus may be a cause of fever and clinical sepsis in the neonatal period
.
•
HPeV-3 might be one of the main agents causing severe neonatal neurological infections
.
What is New:
•
This is the first multicenter prospective study focused on newborns and contributes to a better knowledge of these viral infections. Clinical characteristics of enterovirus and parechovirus infections are compared specifically in the neonatal period
.
•
Knowledge of HPeV infections by paediatricians and neonatologists can guide the diagnosis of these patients and avoid unnecessary treatment and prolonged hospitalization
.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-015-2566-9</identifier><identifier>PMID: 25982340</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Encephalitis ; Encephalitis, Viral - diagnosis ; Encephalitis, Viral - epidemiology ; Encephalitis, Viral - virology ; Enterovirus ; Enterovirus - genetics ; Enterovirus - isolation & purification ; Enterovirus Infections - diagnosis ; Enterovirus Infections - epidemiology ; Enterovirus Infections - virology ; Epidemiology ; Female ; Fever ; Genotype ; Hospitals ; Humans ; Infant, Newborn ; Infections ; Laboratories ; Male ; Medicine ; Medicine & Public Health ; Meningitis ; Original ; Original Article ; Parechovirus - genetics ; Parechovirus - isolation & purification ; Pediatrics ; Picornaviridae Infections - diagnosis ; Picornaviridae Infections - epidemiology ; Picornaviridae Infections - virology ; Prevalence ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Sepsis ; Spain - epidemiology ; Viral infections ; Viremia - diagnosis ; Viremia - epidemiology ; Viremia - virology</subject><ispartof>European journal of pediatrics, 2015-11, Vol.174 (11), p.1511-1516</ispartof><rights>The Author(s) 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c639t-427c344aa81a011008d1d005cb7c55ac7086e48ce34e0bdea943da2fe0e681ca3</citedby><cites>FETCH-LOGICAL-c639t-427c344aa81a011008d1d005cb7c55ac7086e48ce34e0bdea943da2fe0e681ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-015-2566-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-015-2566-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25982340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabrerizo, María</creatorcontrib><creatorcontrib>Trallero, Gloria</creatorcontrib><creatorcontrib>Pena, María José</creatorcontrib><creatorcontrib>Cilla, Amaia</creatorcontrib><creatorcontrib>Megias, Gregoria</creatorcontrib><creatorcontrib>Muñoz-Almagro, Carmen</creatorcontrib><creatorcontrib>Del Amo, Eva</creatorcontrib><creatorcontrib>Roda, Diana</creatorcontrib><creatorcontrib>Mensalvas, Ana Isabel</creatorcontrib><creatorcontrib>Moreno-Docón, Antonio</creatorcontrib><creatorcontrib>García-Costa, Juan</creatorcontrib><creatorcontrib>Rabella, Nuria</creatorcontrib><creatorcontrib>Omeñaca, Manuel</creatorcontrib><creatorcontrib>Romero, María Pilar</creatorcontrib><creatorcontrib>Sanbonmatsu-Gámez, Sara</creatorcontrib><creatorcontrib>Pérez-Ruiz, Mercedes</creatorcontrib><creatorcontrib>Santos-Muñoz, María José</creatorcontrib><creatorcontrib>Calvo, Cristina</creatorcontrib><creatorcontrib>study group of "Enterovirus and parechovirus infections in children under 3 years-old, Spain" PI12-00904</creatorcontrib><creatorcontrib>And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, Spain” PI12-00904</creatorcontrib><title>Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants
<
1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (
p
= 0.03) and meningitis (
p
= 0.001) were significantly more frequent in patients with EV infections than with HPeV.
Conclusions
: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
What is Known
:
•
Human parechovirus may be a cause of fever and clinical sepsis in the neonatal period
.
•
HPeV-3 might be one of the main agents causing severe neonatal neurological infections
.
What is New:
•
This is the first multicenter prospective study focused on newborns and contributes to a better knowledge of these viral infections. Clinical characteristics of enterovirus and parechovirus infections are compared specifically in the neonatal period
.
•
Knowledge of HPeV infections by paediatricians and neonatologists can guide the diagnosis of these patients and avoid unnecessary treatment and prolonged hospitalization
.</description><subject>Encephalitis</subject><subject>Encephalitis, Viral - diagnosis</subject><subject>Encephalitis, Viral - epidemiology</subject><subject>Encephalitis, Viral - virology</subject><subject>Enterovirus</subject><subject>Enterovirus - genetics</subject><subject>Enterovirus - isolation & purification</subject><subject>Enterovirus Infections - diagnosis</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - virology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fever</subject><subject>Genotype</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningitis</subject><subject>Original</subject><subject>Original Article</subject><subject>Parechovirus - genetics</subject><subject>Parechovirus - isolation & purification</subject><subject>Pediatrics</subject><subject>Picornaviridae Infections - diagnosis</subject><subject>Picornaviridae Infections - epidemiology</subject><subject>Picornaviridae Infections - virology</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Sepsis</subject><subject>Spain - epidemiology</subject><subject>Viral infections</subject><subject>Viremia - diagnosis</subject><subject>Viremia - epidemiology</subject><subject>Viremia - virology</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks2KFDEUhQtRnHb0AdxIwI2bGm9-KpVsBGn8gwE3ug7p1K2uDFVJm1Q19HP4wqbodhgFwVUW5zsnNzenql5SuKEA7dsMIDitgTY1a6Ss9aNqQwVnNYVWPq42wAXUkmp9VT3L-Q6KR1P1tLpijVasiJvq5zZOB5t8joHEnuDBdzj5OMb9idjQETf64J0diRtssm7Ggs7e5RX2oUc3-xgy2Z3IsEw2kJKFbohHn5ZMjvmGzEPMuOoYivkidEvyYV80JL1PeSZTDPOwZo6-x-fVk96OGV9czuvq-8cP37af69uvn75s39_WTnI914K1jgthraIWaFmI6mgH0Lhd65rGuhaURKEccoGw69BqwTvLegSUijrLr6t359zDspuwc2XCZEdzSH6y6WSi9eZPJfjB7OPRCMk4KF0C3lwCUvyxYJ7N5LPDcbQB45INbYVUioOE_0CZYk1hWUFf_4XexSWFsomVahvNW71S9Ey5FHNO2N_PTcGs7TDndpjSDrO2w6zzvnr44HvH7zoUgJ2BfFg_CNODq_-Z-guKacjH</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Cabrerizo, María</creator><creator>Trallero, Gloria</creator><creator>Pena, María José</creator><creator>Cilla, Amaia</creator><creator>Megias, Gregoria</creator><creator>Muñoz-Almagro, Carmen</creator><creator>Del Amo, Eva</creator><creator>Roda, Diana</creator><creator>Mensalvas, Ana Isabel</creator><creator>Moreno-Docón, Antonio</creator><creator>García-Costa, Juan</creator><creator>Rabella, Nuria</creator><creator>Omeñaca, Manuel</creator><creator>Romero, María Pilar</creator><creator>Sanbonmatsu-Gámez, Sara</creator><creator>Pérez-Ruiz, Mercedes</creator><creator>Santos-Muñoz, María José</creator><creator>Calvo, Cristina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20151101</creationdate><title>Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life</title><author>Cabrerizo, María ; Trallero, Gloria ; Pena, María José ; Cilla, Amaia ; Megias, Gregoria ; Muñoz-Almagro, Carmen ; Del Amo, Eva ; Roda, Diana ; Mensalvas, Ana Isabel ; Moreno-Docón, Antonio ; García-Costa, Juan ; Rabella, Nuria ; Omeñaca, Manuel ; Romero, María Pilar ; Sanbonmatsu-Gámez, Sara ; Pérez-Ruiz, Mercedes ; Santos-Muñoz, María José ; Calvo, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c639t-427c344aa81a011008d1d005cb7c55ac7086e48ce34e0bdea943da2fe0e681ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Encephalitis</topic><topic>Encephalitis, Viral - diagnosis</topic><topic>Encephalitis, Viral - epidemiology</topic><topic>Encephalitis, Viral - virology</topic><topic>Enterovirus</topic><topic>Enterovirus - genetics</topic><topic>Enterovirus - isolation & purification</topic><topic>Enterovirus Infections - diagnosis</topic><topic>Enterovirus Infections - epidemiology</topic><topic>Enterovirus Infections - virology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fever</topic><topic>Genotype</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningitis</topic><topic>Original</topic><topic>Original Article</topic><topic>Parechovirus - genetics</topic><topic>Parechovirus - isolation & purification</topic><topic>Pediatrics</topic><topic>Picornaviridae Infections - diagnosis</topic><topic>Picornaviridae Infections - epidemiology</topic><topic>Picornaviridae Infections - virology</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Sepsis</topic><topic>Spain - epidemiology</topic><topic>Viral infections</topic><topic>Viremia - diagnosis</topic><topic>Viremia - epidemiology</topic><topic>Viremia - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabrerizo, María</creatorcontrib><creatorcontrib>Trallero, Gloria</creatorcontrib><creatorcontrib>Pena, María José</creatorcontrib><creatorcontrib>Cilla, Amaia</creatorcontrib><creatorcontrib>Megias, Gregoria</creatorcontrib><creatorcontrib>Muñoz-Almagro, Carmen</creatorcontrib><creatorcontrib>Del Amo, Eva</creatorcontrib><creatorcontrib>Roda, Diana</creatorcontrib><creatorcontrib>Mensalvas, Ana Isabel</creatorcontrib><creatorcontrib>Moreno-Docón, Antonio</creatorcontrib><creatorcontrib>García-Costa, Juan</creatorcontrib><creatorcontrib>Rabella, Nuria</creatorcontrib><creatorcontrib>Omeñaca, Manuel</creatorcontrib><creatorcontrib>Romero, María Pilar</creatorcontrib><creatorcontrib>Sanbonmatsu-Gámez, Sara</creatorcontrib><creatorcontrib>Pérez-Ruiz, Mercedes</creatorcontrib><creatorcontrib>Santos-Muñoz, María José</creatorcontrib><creatorcontrib>Calvo, Cristina</creatorcontrib><creatorcontrib>study group of "Enterovirus and parechovirus infections in children under 3 years-old, Spain" PI12-00904</creatorcontrib><creatorcontrib>And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, Spain” PI12-00904</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabrerizo, María</au><au>Trallero, Gloria</au><au>Pena, María José</au><au>Cilla, Amaia</au><au>Megias, Gregoria</au><au>Muñoz-Almagro, Carmen</au><au>Del Amo, Eva</au><au>Roda, Diana</au><au>Mensalvas, Ana Isabel</au><au>Moreno-Docón, Antonio</au><au>García-Costa, Juan</au><au>Rabella, Nuria</au><au>Omeñaca, Manuel</au><au>Romero, María Pilar</au><au>Sanbonmatsu-Gámez, Sara</au><au>Pérez-Ruiz, Mercedes</au><au>Santos-Muñoz, María José</au><au>Calvo, Cristina</au><aucorp>study group of "Enterovirus and parechovirus infections in children under 3 years-old, Spain" PI12-00904</aucorp><aucorp>And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, Spain” PI12-00904</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>174</volume><issue>11</issue><spage>1511</spage><epage>1516</epage><pages>1511-1516</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants
<
1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (
p
= 0.03) and meningitis (
p
= 0.001) were significantly more frequent in patients with EV infections than with HPeV.
Conclusions
: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
What is Known
:
•
Human parechovirus may be a cause of fever and clinical sepsis in the neonatal period
.
•
HPeV-3 might be one of the main agents causing severe neonatal neurological infections
.
What is New:
•
This is the first multicenter prospective study focused on newborns and contributes to a better knowledge of these viral infections. Clinical characteristics of enterovirus and parechovirus infections are compared specifically in the neonatal period
.
•
Knowledge of HPeV infections by paediatricians and neonatologists can guide the diagnosis of these patients and avoid unnecessary treatment and prolonged hospitalization
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25982340</pmid><doi>10.1007/s00431-015-2566-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6199 |
| ispartof | European journal of pediatrics, 2015-11, Vol.174 (11), p.1511-1516 |
| issn | 0340-6199 1432-1076 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4623089 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Encephalitis Encephalitis, Viral - diagnosis Encephalitis, Viral - epidemiology Encephalitis, Viral - virology Enterovirus Enterovirus - genetics Enterovirus - isolation & purification Enterovirus Infections - diagnosis Enterovirus Infections - epidemiology Enterovirus Infections - virology Epidemiology Female Fever Genotype Hospitals Humans Infant, Newborn Infections Laboratories Male Medicine Medicine & Public Health Meningitis Original Original Article Parechovirus - genetics Parechovirus - isolation & purification Pediatrics Picornaviridae Infections - diagnosis Picornaviridae Infections - epidemiology Picornaviridae Infections - virology Prevalence Prospective Studies Real-Time Polymerase Chain Reaction Sepsis Spain - epidemiology Viral infections Viremia - diagnosis Viremia - epidemiology Viremia - virology |
| title | Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A27%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20epidemiology%20and%20clinical%20characteristics%20of%20infections%20by%20human%20parechovirus%20vs.%20those%20by%20enterovirus%20during%20the%20first%20month%20of%20life&rft.jtitle=European%20journal%20of%20pediatrics&rft.au=Cabrerizo,%20Mar%C3%ADa&rft.aucorp=study%20group%20of%20%22Enterovirus%20and%20parechovirus%20infections%20in%20children%20under%203%C2%A0years-old,%20Spain%22%20PI12-00904&rft.date=2015-11-01&rft.volume=174&rft.issue=11&rft.spage=1511&rft.epage=1516&rft.pages=1511-1516&rft.issn=0340-6199&rft.eissn=1432-1076&rft_id=info:doi/10.1007/s00431-015-2566-9&rft_dat=%3Cproquest_pubme%3E1728258302%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1727593792&rft_id=info:pmid/25982340&rfr_iscdi=true |