Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis
AIM： To focus on the role of CD40 and CD40L in their pathogenesis. METHODS： We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-09, Vol.11 (34), p.5303-5308 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Polese, Lino Angriman, Imerio Giuseppe, De Franchis Cecchetto, Attilio Sturniolo, Giacomo-C Renata, D'Inca Scarpa, Marco Ruffolo, Cesare Norberto, Lorenzo Frego, Mauro D'Amico, Davide-F |
| description | AIM： To focus on the role of CD40 and CD40L in their pathogenesis.
METHODS： We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CEH0 by B lymphoo/tes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls. RESULTS： Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlated with the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.
CONCLUSION： High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations. |
| doi_str_mv | 10.3748/wjg.v11.i34.5303 |
| format | Article |
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METHODS： We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CEH0 by B lymphoo/tes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls. RESULTS： Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlated with the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.
CONCLUSION： High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i34.5303</identifier><identifier>PMID: 16149136</identifier><language>eng</language><publisher>United States: Department of Gastroenterological and Surgical Sciences. Surgical Unit, University of Padova, Italy%Department of Laboratory Medicine, University of Padova, Italy%Department of Pathology, University of Padova, Italy%Department of Gastroenterological and Surgical Sciences, astroenterological Unit, University of Padova, Italy</publisher><subject>Adult ; CD40 ; CD40 Antigens - metabolism ; CD40 Ligand - metabolism ; CD40L ; Clinical Research ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - surgery ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Postoperative Complications - metabolism ; Pouchitis - metabolism ; Proctocolectomy, Restorative ; 基因表达 ; 大肠炎 ; 滋补剂</subject><ispartof>World journal of gastroenterology : WJG, 2005-09, Vol.11 (34), p.5303-5308</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-74afcb990070af305b0a27dddc4f787d948deb88449998883fda4622574a29443</citedby><cites>FETCH-LOGICAL-c450t-74afcb990070af305b0a27dddc4f787d948deb88449998883fda4622574a29443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622799/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622799/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16149136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polese, Lino</creatorcontrib><creatorcontrib>Angriman, Imerio</creatorcontrib><creatorcontrib>Giuseppe, De Franchis</creatorcontrib><creatorcontrib>Cecchetto, Attilio</creatorcontrib><creatorcontrib>Sturniolo, Giacomo-C</creatorcontrib><creatorcontrib>Renata, D'Inca</creatorcontrib><creatorcontrib>Scarpa, Marco</creatorcontrib><creatorcontrib>Ruffolo, Cesare</creatorcontrib><creatorcontrib>Norberto, Lorenzo</creatorcontrib><creatorcontrib>Frego, Mauro</creatorcontrib><creatorcontrib>D'Amico, Davide-F</creatorcontrib><title>Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To focus on the role of CD40 and CD40L in their pathogenesis.
METHODS： We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CEH0 by B lymphoo/tes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls. RESULTS： Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlated with the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.
CONCLUSION： High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations.</description><subject>Adult</subject><subject>CD40</subject><subject>CD40 Antigens - metabolism</subject><subject>CD40 Ligand - metabolism</subject><subject>CD40L</subject><subject>Clinical Research</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colitis, Ulcerative - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - metabolism</subject><subject>Pouchitis - metabolism</subject><subject>Proctocolectomy, Restorative</subject><subject>基因表达</subject><subject>大肠炎</subject><subject>滋补剂</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcuO0zAUtRCIKQN7VshCiF3K9SOJvUEaladUCRawthzHbl1Su2MnHebvcWjEY3VtnYeP70HoOYE1a7l4c3fYrc-ErD3j65oBe4BWlBJZUcHhIVoRgLaSjLZX6EnOBwDKWE0foyvSEC4Ja1bIfbUp-zzaYCyODu_9bo837zhgHfrfhy22P0_J5uxjwNqNNuFyG2PSoz9bfErRjNHEwZZxvMcuJjwNxi5wAfzo81P0yOkh22fLvEbfP7z_tvlUbb98_Ly52VaG1zBWLdfOdFKW3KAdg7oDTdu-7w13rWh7yUVvOyE4l1IKIZjrNW8orYuQSs7ZNXp78T1N3dH2xoYx6UGdkj_qdK-i9up_JPi92sWzml1aKYvBq4vBnQ5Oh506xCmFElmVXVOAmnEAUWivl3dSvJ3KOtTRZ2OHQQcbp6waUTeMtHMguBBNijkn6_5kIaDmDmdfVTpUpUM1d1gkL_79w1_BUlohvFw89zHsbn1J2Wnzw_nBKgqciabm7BcNJ6VS</recordid><startdate>20050914</startdate><enddate>20050914</enddate><creator>Polese, Lino</creator><creator>Angriman, Imerio</creator><creator>Giuseppe, De Franchis</creator><creator>Cecchetto, Attilio</creator><creator>Sturniolo, Giacomo-C</creator><creator>Renata, D'Inca</creator><creator>Scarpa, Marco</creator><creator>Ruffolo, Cesare</creator><creator>Norberto, Lorenzo</creator><creator>Frego, Mauro</creator><creator>D'Amico, Davide-F</creator><general>Department of Gastroenterological and Surgical Sciences. 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METHODS： We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CEH0 by B lymphoo/tes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls. RESULTS： Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlated with the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.
CONCLUSION： High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations.</abstract><cop>United States</cop><pub>Department of Gastroenterological and Surgical Sciences. Surgical Unit, University of Padova, Italy%Department of Laboratory Medicine, University of Padova, Italy%Department of Pathology, University of Padova, Italy%Department of Gastroenterological and Surgical Sciences, astroenterological Unit, University of Padova, Italy</pub><pmid>16149136</pmid><doi>10.3748/wjg.v11.i34.5303</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult CD40 CD40 Antigens - metabolism CD40 Ligand - metabolism CD40L Clinical Research Colitis, Ulcerative - metabolism Colitis, Ulcerative - surgery Female Humans Immunohistochemistry Male Middle Aged Postoperative Complications - metabolism Pouchitis - metabolism Proctocolectomy, Restorative 基因表达 大肠炎 滋补剂 |
| title | Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis |
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