Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics
Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the c...
Gespeichert in:
| Veröffentlicht in: | Biochemia Medica 2015-01, Vol.25 (3), p.469-473 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 473 |
|---|---|
| container_issue | 3 |
| container_start_page | 469 |
| container_title | Biochemia Medica |
| container_volume | 25 |
| creator | Katchunga, Philippe B Mirindi, Patrick N Kishabongo, Antoine S Cikomola, Justin C Bwanamdogo, Socrate Philippé, Jan Speeckaert, Marijn M Delanghe, Joris R |
| description | Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short- and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker.
This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek® Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+®) were measured at start and after 6 months.
ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 μmol/g nail. Concentration of glycated nail proteins was significantly higher (P |
| doi_str_mv | 10.11613/BM.2015.048 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4622194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1730021564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-c6584494d453ba9c4083bdbd9709140d3ebe39b1edfd6e11921588dc7b03b6123</originalsourceid><addsrcrecordid>eNpVkUlvFDEQhVsIRBa4cUY-cqAn3tu-IJERhCiJOABHZHmpmTHptid2d1D-fXqYJCKSpSq5nr961muadwQvCJGEnZxeLSgmYoG5etEcEsVl23FFX849Y7jFWtKD5qjWPxgLIVT3ujmgUlCpO3HY_D7r77wdIaBkY4-2JY8QU0V2PijBX-RiHmy5hoJiQoNNdg0DpBHlFRo3gH7kadygi3g7oWVO69xDBRSidTBGX980r1a2r_D2oR43v75--bn81l5-Pztffr5sPad0bL0UinPNAxfMWe05VswFF3SHNeE4MHDAtCMQVkECIZoSoVTwncPMSULZcfNpz91OboDgZ4PF9mZb4uz9zmQbzfNJihuzzreGS0qJ5jOg3QM2xdvrZw_3N7V4mFtDuJJ6t_DDw8KSbyaooxli9dD3NkGeqiEdw3h2KXfoj3upL7nWAqsnOsHmX4Lm9MrsEjRzgrP8_f9feRI_RsbuAT1bl5s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1730021564</pqid></control><display><type>article</type><title>Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Katchunga, Philippe B ; Mirindi, Patrick N ; Kishabongo, Antoine S ; Cikomola, Justin C ; Bwanamdogo, Socrate ; Philippé, Jan ; Speeckaert, Marijn M ; Delanghe, Joris R</creator><creatorcontrib>Katchunga, Philippe B ; Mirindi, Patrick N ; Kishabongo, Antoine S ; Cikomola, Justin C ; Bwanamdogo, Socrate ; Philippé, Jan ; Speeckaert, Marijn M ; Delanghe, Joris R</creatorcontrib><description>Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short- and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker.
This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek® Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+®) were measured at start and after 6 months.
ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 μmol/g nail. Concentration of glycated nail proteins was significantly higher (P<0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P=0.017) and concentration of glycated nail proteins (P=0.008) was observed in contrast to serum fructosamine and HbA1c.
Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.</description><identifier>ISSN: 1330-0962</identifier><identifier>ISSN: 1846-7482</identifier><identifier>EISSN: 1846-7482</identifier><identifier>DOI: 10.11613/BM.2015.048</identifier><identifier>PMID: 26526975</identifier><language>eng</language><publisher>Croatia: Medicinska naklada</publisher><subject>Adult ; Aged ; Area Under Curve ; Biomarkers - analysis ; Blood Glucose - analysis ; Case-Control Studies ; Colorimetry - methods ; Democratic Republic of the Congo - epidemiology ; Developing Countries ; diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Disease Management ; Drug Monitoring ; Fasting - blood ; fasting glucose concentration ; Female ; Follow-Up Studies ; fructosamine ; Fructosamine - blood ; Glycated Hemoglobin A - analysis ; Glycation End Products, Advanced - analysis ; hemoglobin A1c protein ; Humans ; Hypoglycemic Agents - therapeutic use ; Male ; Middle Aged ; nails ; Nails - chemistry ; ROC Curve ; sub-Saharan Africa ; Young Adult</subject><ispartof>Biochemia Medica, 2015-01, Vol.25 (3), p.469-473</ispartof><rights>2015 Croatian Society of Medical Biochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-c6584494d453ba9c4083bdbd9709140d3ebe39b1edfd6e11921588dc7b03b6123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622194/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622194/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26526975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katchunga, Philippe B</creatorcontrib><creatorcontrib>Mirindi, Patrick N</creatorcontrib><creatorcontrib>Kishabongo, Antoine S</creatorcontrib><creatorcontrib>Cikomola, Justin C</creatorcontrib><creatorcontrib>Bwanamdogo, Socrate</creatorcontrib><creatorcontrib>Philippé, Jan</creatorcontrib><creatorcontrib>Speeckaert, Marijn M</creatorcontrib><creatorcontrib>Delanghe, Joris R</creatorcontrib><title>Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics</title><title>Biochemia Medica</title><addtitle>Biochem Med (Zagreb)</addtitle><description>Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short- and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker.
This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek® Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+®) were measured at start and after 6 months.
ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 μmol/g nail. Concentration of glycated nail proteins was significantly higher (P<0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P=0.017) and concentration of glycated nail proteins (P=0.008) was observed in contrast to serum fructosamine and HbA1c.
Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.</description><subject>Adult</subject><subject>Aged</subject><subject>Area Under Curve</subject><subject>Biomarkers - analysis</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Colorimetry - methods</subject><subject>Democratic Republic of the Congo - epidemiology</subject><subject>Developing Countries</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Disease Management</subject><subject>Drug Monitoring</subject><subject>Fasting - blood</subject><subject>fasting glucose concentration</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>fructosamine</subject><subject>Fructosamine - blood</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycation End Products, Advanced - analysis</subject><subject>hemoglobin A1c protein</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nails</subject><subject>Nails - chemistry</subject><subject>ROC Curve</subject><subject>sub-Saharan Africa</subject><subject>Young Adult</subject><issn>1330-0962</issn><issn>1846-7482</issn><issn>1846-7482</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlvFDEQhVsIRBa4cUY-cqAn3tu-IJERhCiJOABHZHmpmTHptid2d1D-fXqYJCKSpSq5nr961muadwQvCJGEnZxeLSgmYoG5etEcEsVl23FFX849Y7jFWtKD5qjWPxgLIVT3ujmgUlCpO3HY_D7r77wdIaBkY4-2JY8QU0V2PijBX-RiHmy5hoJiQoNNdg0DpBHlFRo3gH7kadygi3g7oWVO69xDBRSidTBGX980r1a2r_D2oR43v75--bn81l5-Pztffr5sPad0bL0UinPNAxfMWe05VswFF3SHNeE4MHDAtCMQVkECIZoSoVTwncPMSULZcfNpz91OboDgZ4PF9mZb4uz9zmQbzfNJihuzzreGS0qJ5jOg3QM2xdvrZw_3N7V4mFtDuJJ6t_DDw8KSbyaooxli9dD3NkGeqiEdw3h2KXfoj3upL7nWAqsnOsHmX4Lm9MrsEjRzgrP8_f9feRI_RsbuAT1bl5s</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Katchunga, Philippe B</creator><creator>Mirindi, Patrick N</creator><creator>Kishabongo, Antoine S</creator><creator>Cikomola, Justin C</creator><creator>Bwanamdogo, Socrate</creator><creator>Philippé, Jan</creator><creator>Speeckaert, Marijn M</creator><creator>Delanghe, Joris R</creator><general>Medicinska naklada</general><general>Croatian Society of Medical Biochemistry and Laboratory Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>VP8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics</title><author>Katchunga, Philippe B ; Mirindi, Patrick N ; Kishabongo, Antoine S ; Cikomola, Justin C ; Bwanamdogo, Socrate ; Philippé, Jan ; Speeckaert, Marijn M ; Delanghe, Joris R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-c6584494d453ba9c4083bdbd9709140d3ebe39b1edfd6e11921588dc7b03b6123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Area Under Curve</topic><topic>Biomarkers - analysis</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Colorimetry - methods</topic><topic>Democratic Republic of the Congo - epidemiology</topic><topic>Developing Countries</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Disease Management</topic><topic>Drug Monitoring</topic><topic>Fasting - blood</topic><topic>fasting glucose concentration</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>fructosamine</topic><topic>Fructosamine - blood</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycation End Products, Advanced - analysis</topic><topic>hemoglobin A1c protein</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nails</topic><topic>Nails - chemistry</topic><topic>ROC Curve</topic><topic>sub-Saharan Africa</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katchunga, Philippe B</creatorcontrib><creatorcontrib>Mirindi, Patrick N</creatorcontrib><creatorcontrib>Kishabongo, Antoine S</creatorcontrib><creatorcontrib>Cikomola, Justin C</creatorcontrib><creatorcontrib>Bwanamdogo, Socrate</creatorcontrib><creatorcontrib>Philippé, Jan</creatorcontrib><creatorcontrib>Speeckaert, Marijn M</creatorcontrib><creatorcontrib>Delanghe, Joris R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemia Medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katchunga, Philippe B</au><au>Mirindi, Patrick N</au><au>Kishabongo, Antoine S</au><au>Cikomola, Justin C</au><au>Bwanamdogo, Socrate</au><au>Philippé, Jan</au><au>Speeckaert, Marijn M</au><au>Delanghe, Joris R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics</atitle><jtitle>Biochemia Medica</jtitle><addtitle>Biochem Med (Zagreb)</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>25</volume><issue>3</issue><spage>469</spage><epage>473</epage><pages>469-473</pages><issn>1330-0962</issn><issn>1846-7482</issn><eissn>1846-7482</eissn><abstract>Diagnosis and monitoring of diabetes mellitus in sub-Saharan Africa, based on blood analyses, are hampered by infrastructural and cultural reasons. The first aim of this study was to evaluate the diagnostic accuracy of glycated nail proteins for diabetes mellitus. The second aim was to compare the course of short- and long-term glycemic biomarkers after 6 months of antidiabetic treatment. These objectives should support our hypothesis that glycated nail proteins could be used as an alternative glycemic biomarker.
This case-control study consisted of 163 black diabetics and 67 non-diabetics of the South Kivu (Democratic Republic of Congo). Diagnostic accuracy of glycated nail proteins was evaluated using ROC curve analysis. At the start of the study, glycated nail protein concentrations were compared between diabetics and non-diabetics, using a nitro blue tetrazolium (NBT) colorimetric method. In a subgroup of 30 diabetics, concentrations of glycated nail proteins, fasting glucose (Accu-Chek® Aviva), serum fructosamine (NBT) and HbA1c (DCA-2000+®) were measured at start and after 6 months.
ROC analysis yielded an AUC of 0.71 (95% confidence interval (CI): 0.65-0.76) and a cut-off point of 3.83 μmol/g nail. Concentration of glycated nail proteins was significantly higher (P<0.001) in diabetics in comparison with non-diabetics. After 6 months of antidiabetic treatment, a significant drop in the fasting glucose concentration (P=0.017) and concentration of glycated nail proteins (P=0.008) was observed in contrast to serum fructosamine and HbA1c.
Measurement of glycated nail proteins could be used to diagnose and monitor diabetes mellitus in sub-Saharan Africa.</abstract><cop>Croatia</cop><pub>Medicinska naklada</pub><pmid>26526975</pmid><doi>10.11613/BM.2015.048</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1330-0962 |
| ispartof | Biochemia Medica, 2015-01, Vol.25 (3), p.469-473 |
| issn | 1330-0962 1846-7482 1846-7482 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4622194 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Area Under Curve Biomarkers - analysis Blood Glucose - analysis Case-Control Studies Colorimetry - methods Democratic Republic of the Congo - epidemiology Developing Countries diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Disease Management Drug Monitoring Fasting - blood fasting glucose concentration Female Follow-Up Studies fructosamine Fructosamine - blood Glycated Hemoglobin A - analysis Glycation End Products, Advanced - analysis hemoglobin A1c protein Humans Hypoglycemic Agents - therapeutic use Male Middle Aged nails Nails - chemistry ROC Curve sub-Saharan Africa Young Adult |
| title | Glycated nail proteins as a new biomarker in management of the South Kivu Congolese diabetics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T09%3A11%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glycated%20nail%20proteins%20as%20a%20new%20biomarker%20in%20management%20of%20the%20South%20Kivu%20Congolese%20diabetics&rft.jtitle=Biochemia%20Medica&rft.au=Katchunga,%20Philippe%20B&rft.date=2015-01-01&rft.volume=25&rft.issue=3&rft.spage=469&rft.epage=473&rft.pages=469-473&rft.issn=1330-0962&rft.eissn=1846-7482&rft_id=info:doi/10.11613/BM.2015.048&rft_dat=%3Cproquest_pubme%3E1730021564%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1730021564&rft_id=info:pmid/26526975&rfr_iscdi=true |