Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery: a randomised-controlled trial

BackgroundElafin is a potent endogenous neutrophil elastase inhibitor that protects against myocardial inflammation and injury in preclinical models of ischaemic-reperfusion injury. We investigated whether elafin could inhibit myocardial ischaemia-reperfusion injury induced during coronary artery by...

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Veröffentlicht in:	Heart (British Cardiac Society) 2015-10, Vol.101 (20), p.1639-1645
Hauptverfasser:	Alam, S R, Lewis, S C, Zamvar, V, Pessotto, R, Dweck, M R, Krishan, A, Goodman, K, Oatey, K, Harkess, R, Milne, L, Thomas, S, Mills, N M, Moore, C, Semple, S, Wiedow, O, Stirrat, C, Mirsadraee, S, Newby, D E, Henriksen, P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous solutions Cardiovascular disease Clinical trials Coronary Artery Bypass - adverse effects Coronary Artery Disease Coronary Artery Disease - surgery Coronary vessels Double-Blind Method Elafin - administration & dosage Follow-Up Studies Heart attacks Heart surgery Humans Inflammation Infusions, Intravenous Intraoperative Complications - drug therapy Intraoperative Complications - etiology Intraoperative Period Magnetic Resonance Imaging, Cine Myocardial Reperfusion Injury - diagnosis Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - etiology Neutrophils Plasma Protease Inhibitors - administration & dosage Recombinant Proteins Retrospective Studies Rodents Transgenic animals Tumor necrosis factor-TNF
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