Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1

STING is a protein in the cytosolic DNA and cyclic dinucleotide sensor pathway that is critical for the initiation of innate responses to infection by various pathogens. Consistent with this, herpes simplex virus 1 (HSV-1) causes invariable and rapid lethality in STING-deficient (STING(-/-)) mice fo...

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Veröffentlicht in:	Journal of virology 2015-11, Vol.89 (21), p.11080-11091
Hauptverfasser:	Parker, Zachary M, Murphy, Aisling A, Leib, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cercopithecus aethiops Cerebrum - virology Chemokine CXCL9 - metabolism Cornea - virology Cytokines - blood Herpes Simplex - physiopathology Herpes Simplex - prevention & control Herpes simplex virus 1 Herpesvirus 1, Human - pathogenicity Luminescent Measurements Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Pathogenesis and Immunity Real-Time Polymerase Chain Reaction Tumor Necrosis Factor-alpha - metabolism Vero Cells
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