Epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina

Estrogen-mediated actions in female reproductive organs are tightly regulated, mainly through estrogen receptor 1 (ESR1). The mouse vaginal epithelium cyclically exhibits cell proliferation and differentiation in response to estrogen and provides a unique model for analyzing the homeostasis of strat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-10, Vol.112 (42), p.12986-12991
Hauptverfasser:	Miyagawa, Shinichi, Iguchi, Taisen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Death - physiology Cell Differentiation - physiology Cell Proliferation - physiology Epithelium - metabolism Estrogen Receptor alpha - genetics Estrogen Receptor alpha - physiology Estrogens Experiments Female Gene expression Homeostasis Mice Mice, Inbred C57BL Mice, Knockout Rodents Urogenital system Vagina - pathology
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