Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation

Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellular mechanisms of SP in CE in vitro, taking advantag...

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Veröffentlicht in:	Journal of neurophysiology 2015-10, Vol.114 (4), p.2500-2508
Hauptverfasser:	Sosulina, L, Strippel, C, Romo-Parra, H, Walter, A L, Kanyshkova, T, Sartori, S B, Lange, M D, Singewald, N, Pape, H-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Amygdaloid Nucleus - drug effects Central Amygdaloid Nucleus - physiology Fluorescent Antibody Technique GABAergic Neurons - drug effects GABAergic Neurons - physiology Gene Knock-In Techniques Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Male Membrane Potentials - drug effects Membrane Potentials - physiology Mice, Inbred C57BL Mice, Transgenic Neural Circuits Neurokinin-1 Receptor Antagonists - pharmacology Patch-Clamp Techniques Piperidines - pharmacology Potassium - metabolism Protein Kinase C-delta - metabolism Receptors, Neurokinin-1 - metabolism Substance P - metabolism Tissue Culture Techniques
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