Stereoselective synthesis of macrocyclic peptides via a dual olefin metathesis and ethenolysis approach† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01507c Click here for additional data file

A metathesis strategy for controlling olefin geometry within macrocyclic peptides has been achieved using catalyst-directed RCM and ethenolysis. Macrocyclic compounds occupy an important chemical space between small molecules and biologics and are prevalent in many natural products and pharmaceutica...

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Veröffentlicht in:	Chemical science (Cambridge) 2015-05, Vol.6 (8), p.4561-4569
Hauptverfasser:	Mangold, Shane L., Grubbs, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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