A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study
The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke...
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| Veröffentlicht in: | BMC neurology 2015-10, Vol.15 (1), p.212-212, Article 212 |
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| creator | Kamal, Ayeesha Kamran Shaikh, Quratulain Pasha, Omrana Azam, Iqbal Islam, Muhammad Memon, Adeel Ali Rehman, Hasan Akram, Masood Ahmed Affan, Muhammad Nazir, Sumaira Aziz, Salman Jan, Muhammad Andani, Anita Muqeet, Abdul Ahmed, Bilal Khoja, Shariq |
| description | The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke survivors in Pakistan.
This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition to usual care, received reminder SMS for 2 months that contained a) Personalized, prescription tailored daily medication reminder(s) b) Twice weekly health information SMS. The Health Belief Model and Social Cognitive theory were used to design the language and content of messages. Frontline SMS software was used for SMS delivery. Medication adherence was self-reported and measured on the validated Urdu version of Morisky Medication Adherence Questionnaire. Multiple linear regression was used to model the outcome against intervention and other covariates. Analysis was conducted by intention-to-treat principle.
Two hundred participants were enrolled. 38 participants were lost to follow-up. After 2 months, the mean medication score was 7.4 (95 % CI: 7.2-7.6) in the intervention group while 6.7 (95 % CI: 6.4-7.02) in the control group. The adjusted mean difference (Δ) was 0.54 (95 % CI: 0.22-0.85). The mean diastolic blood pressure in the intervention group was 2.6 mmHg (95 % CI; -5.5 to 0.15) lower compared to the usual care group.
A short intervention of customized SMS can improve medication adherence and effect stroke risk factors like diastolic blood pressure in stroke survivors with complex medication regimens living in resource poor areas.
Clinicaltrials.gov NCT01986023 last accessed at https://clinicaltrials.gov/ct2/show/NCT01986023. |
| doi_str_mv | 10.1186/s12883-015-0471-5 |
| format | Article |
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This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition to usual care, received reminder SMS for 2 months that contained a) Personalized, prescription tailored daily medication reminder(s) b) Twice weekly health information SMS. The Health Belief Model and Social Cognitive theory were used to design the language and content of messages. Frontline SMS software was used for SMS delivery. Medication adherence was self-reported and measured on the validated Urdu version of Morisky Medication Adherence Questionnaire. Multiple linear regression was used to model the outcome against intervention and other covariates. Analysis was conducted by intention-to-treat principle.
Two hundred participants were enrolled. 38 participants were lost to follow-up. After 2 months, the mean medication score was 7.4 (95 % CI: 7.2-7.6) in the intervention group while 6.7 (95 % CI: 6.4-7.02) in the control group. The adjusted mean difference (Δ) was 0.54 (95 % CI: 0.22-0.85). The mean diastolic blood pressure in the intervention group was 2.6 mmHg (95 % CI; -5.5 to 0.15) lower compared to the usual care group.
A short intervention of customized SMS can improve medication adherence and effect stroke risk factors like diastolic blood pressure in stroke survivors with complex medication regimens living in resource poor areas.
Clinicaltrials.gov NCT01986023 last accessed at https://clinicaltrials.gov/ct2/show/NCT01986023.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/s12883-015-0471-5</identifier><identifier>PMID: 26486857</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Antihypertensive Agents - therapeutic use ; Behavior Therapy - methods ; Blood Pressure ; Cell Phone ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Medication Adherence ; Middle Aged ; Pakistan ; Patient compliance ; Platelet Aggregation Inhibitors - therapeutic use ; Psychological Theory ; Reminder Systems ; Secondary Prevention ; Single-Blind Method ; Stroke - drug therapy ; Stroke patients ; Text Messaging</subject><ispartof>BMC neurology, 2015-10, Vol.15 (1), p.212-212, Article 212</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Kamal et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-9ceed3487d92a0fd2554e9222d93eaca21ddd5e1c0ade133284835e9dac75bd43</citedby><cites>FETCH-LOGICAL-c494t-9ceed3487d92a0fd2554e9222d93eaca21ddd5e1c0ade133284835e9dac75bd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26486857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamal, Ayeesha Kamran</creatorcontrib><creatorcontrib>Shaikh, Quratulain</creatorcontrib><creatorcontrib>Pasha, Omrana</creatorcontrib><creatorcontrib>Azam, Iqbal</creatorcontrib><creatorcontrib>Islam, Muhammad</creatorcontrib><creatorcontrib>Memon, Adeel Ali</creatorcontrib><creatorcontrib>Rehman, Hasan</creatorcontrib><creatorcontrib>Akram, Masood Ahmed</creatorcontrib><creatorcontrib>Affan, Muhammad</creatorcontrib><creatorcontrib>Nazir, Sumaira</creatorcontrib><creatorcontrib>Aziz, Salman</creatorcontrib><creatorcontrib>Jan, Muhammad</creatorcontrib><creatorcontrib>Andani, Anita</creatorcontrib><creatorcontrib>Muqeet, Abdul</creatorcontrib><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Khoja, Shariq</creatorcontrib><title>A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke survivors in Pakistan.
This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition to usual care, received reminder SMS for 2 months that contained a) Personalized, prescription tailored daily medication reminder(s) b) Twice weekly health information SMS. The Health Belief Model and Social Cognitive theory were used to design the language and content of messages. Frontline SMS software was used for SMS delivery. Medication adherence was self-reported and measured on the validated Urdu version of Morisky Medication Adherence Questionnaire. Multiple linear regression was used to model the outcome against intervention and other covariates. Analysis was conducted by intention-to-treat principle.
Two hundred participants were enrolled. 38 participants were lost to follow-up. After 2 months, the mean medication score was 7.4 (95 % CI: 7.2-7.6) in the intervention group while 6.7 (95 % CI: 6.4-7.02) in the control group. The adjusted mean difference (Δ) was 0.54 (95 % CI: 0.22-0.85). The mean diastolic blood pressure in the intervention group was 2.6 mmHg (95 % CI; -5.5 to 0.15) lower compared to the usual care group.
A short intervention of customized SMS can improve medication adherence and effect stroke risk factors like diastolic blood pressure in stroke survivors with complex medication regimens living in resource poor areas.
Clinicaltrials.gov NCT01986023 last accessed at https://clinicaltrials.gov/ct2/show/NCT01986023.</description><subject>Analysis</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Behavior Therapy - methods</subject><subject>Blood Pressure</subject><subject>Cell Phone</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Male</subject><subject>Medication Adherence</subject><subject>Middle Aged</subject><subject>Pakistan</subject><subject>Patient compliance</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Psychological Theory</subject><subject>Reminder Systems</subject><subject>Secondary Prevention</subject><subject>Single-Blind Method</subject><subject>Stroke - drug therapy</subject><subject>Stroke patients</subject><subject>Text Messaging</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptks1u1DAUhSMEoqXwAGyQJTZlkRL_xckGaVTxJ7ViMbC2XPvOjEtiB9uZqjwZj8edTiktQpGSG_uc7-Y6p6pe0uaE0q59mynrOl43VNaNULSWj6pDuisYV-rxvfqgepbzZdNQ1Qn6tDpgrejaTqrD6teCJBNcHP1PcMTGUFIcBiwvYGO2PiYzEB8KpC2E4mMgJXlcKpH4cUpxC2QE56252TNuAwmCBbTgyzwUkpH3HciEAgRkcuXLhkwJsk1-2gONH2LCjstNTIWcQ85m7cOaLLGpR9bx8nz5psabWO5huczu-nn1ZGWGDC9un0fVtw_vv55-qs--fPx8ujirrehFqXsL4LjolOuZaVaOSSmgZ4y5noOxhlHnnARqG-OAcs460XEJvTNWyQsn-FH1bs-d5gsc1eIUeCZ6Sn406VpH4_XDneA3eh23WrS0461CwPEtIMUfM-SiR58tDIMJEOesqcJvYkzJBqWv_5FexjkFHA9Vqle0kar9q1qbAbQPq4h97Q6qF1JQ3kt50_bkPyq8HIwe_zOsPK4_MNC9waaYc4LV3Yy00bu46X3cNMZN7-KmJXpe3T-cO8effPHfdO_VCA</recordid><startdate>20151021</startdate><enddate>20151021</enddate><creator>Kamal, Ayeesha Kamran</creator><creator>Shaikh, Quratulain</creator><creator>Pasha, Omrana</creator><creator>Azam, Iqbal</creator><creator>Islam, Muhammad</creator><creator>Memon, Adeel Ali</creator><creator>Rehman, Hasan</creator><creator>Akram, Masood Ahmed</creator><creator>Affan, Muhammad</creator><creator>Nazir, Sumaira</creator><creator>Aziz, Salman</creator><creator>Jan, Muhammad</creator><creator>Andani, Anita</creator><creator>Muqeet, Abdul</creator><creator>Ahmed, Bilal</creator><creator>Khoja, Shariq</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151021</creationdate><title>A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study</title><author>Kamal, Ayeesha Kamran ; Shaikh, Quratulain ; Pasha, Omrana ; Azam, Iqbal ; Islam, Muhammad ; Memon, Adeel Ali ; Rehman, Hasan ; Akram, Masood Ahmed ; Affan, Muhammad ; Nazir, Sumaira ; Aziz, Salman ; Jan, Muhammad ; Andani, Anita ; Muqeet, Abdul ; Ahmed, Bilal ; Khoja, Shariq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-9ceed3487d92a0fd2554e9222d93eaca21ddd5e1c0ade133284835e9dac75bd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Behavior Therapy - methods</topic><topic>Blood Pressure</topic><topic>Cell Phone</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Male</topic><topic>Medication Adherence</topic><topic>Middle Aged</topic><topic>Pakistan</topic><topic>Patient compliance</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Psychological Theory</topic><topic>Reminder Systems</topic><topic>Secondary Prevention</topic><topic>Single-Blind Method</topic><topic>Stroke - drug therapy</topic><topic>Stroke patients</topic><topic>Text Messaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamal, Ayeesha Kamran</creatorcontrib><creatorcontrib>Shaikh, Quratulain</creatorcontrib><creatorcontrib>Pasha, Omrana</creatorcontrib><creatorcontrib>Azam, Iqbal</creatorcontrib><creatorcontrib>Islam, Muhammad</creatorcontrib><creatorcontrib>Memon, Adeel Ali</creatorcontrib><creatorcontrib>Rehman, Hasan</creatorcontrib><creatorcontrib>Akram, Masood Ahmed</creatorcontrib><creatorcontrib>Affan, Muhammad</creatorcontrib><creatorcontrib>Nazir, Sumaira</creatorcontrib><creatorcontrib>Aziz, Salman</creatorcontrib><creatorcontrib>Jan, Muhammad</creatorcontrib><creatorcontrib>Andani, Anita</creatorcontrib><creatorcontrib>Muqeet, Abdul</creatorcontrib><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Khoja, Shariq</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamal, Ayeesha Kamran</au><au>Shaikh, Quratulain</au><au>Pasha, Omrana</au><au>Azam, Iqbal</au><au>Islam, Muhammad</au><au>Memon, Adeel Ali</au><au>Rehman, Hasan</au><au>Akram, Masood Ahmed</au><au>Affan, Muhammad</au><au>Nazir, Sumaira</au><au>Aziz, Salman</au><au>Jan, Muhammad</au><au>Andani, Anita</au><au>Muqeet, Abdul</au><au>Ahmed, Bilal</au><au>Khoja, Shariq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2015-10-21</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>212</spage><epage>212</epage><pages>212-212</pages><artnum>212</artnum><issn>1471-2377</issn><eissn>1471-2377</eissn><abstract>The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke survivors in Pakistan.
This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition to usual care, received reminder SMS for 2 months that contained a) Personalized, prescription tailored daily medication reminder(s) b) Twice weekly health information SMS. The Health Belief Model and Social Cognitive theory were used to design the language and content of messages. Frontline SMS software was used for SMS delivery. Medication adherence was self-reported and measured on the validated Urdu version of Morisky Medication Adherence Questionnaire. Multiple linear regression was used to model the outcome against intervention and other covariates. Analysis was conducted by intention-to-treat principle.
Two hundred participants were enrolled. 38 participants were lost to follow-up. After 2 months, the mean medication score was 7.4 (95 % CI: 7.2-7.6) in the intervention group while 6.7 (95 % CI: 6.4-7.02) in the control group. The adjusted mean difference (Δ) was 0.54 (95 % CI: 0.22-0.85). The mean diastolic blood pressure in the intervention group was 2.6 mmHg (95 % CI; -5.5 to 0.15) lower compared to the usual care group.
A short intervention of customized SMS can improve medication adherence and effect stroke risk factors like diastolic blood pressure in stroke survivors with complex medication regimens living in resource poor areas.
Clinicaltrials.gov NCT01986023 last accessed at https://clinicaltrials.gov/ct2/show/NCT01986023.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26486857</pmid><doi>10.1186/s12883-015-0471-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC neurology, 2015-10, Vol.15 (1), p.212-212, Article 212 |
| issn | 1471-2377 1471-2377 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA/Free Journals; PubMed Central Open Access |
| subjects | Analysis Antihypertensive Agents - therapeutic use Behavior Therapy - methods Blood Pressure Cell Phone Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Medication Adherence Middle Aged Pakistan Patient compliance Platelet Aggregation Inhibitors - therapeutic use Psychological Theory Reminder Systems Secondary Prevention Single-Blind Method Stroke - drug therapy Stroke patients Text Messaging |
| title | A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study |
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