Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases
The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs). We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60....
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| Veröffentlicht in: | World journal of surgical oncology 2015-10, Vol.13 (1), p.304-304, Article 304 |
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| container_title | World journal of surgical oncology |
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| creator | Li, Wentao Zhang, Binfei Kang, Wenxing Dong, Boning Ma, Xudong Song, Jinning Liu, Yonghong Liang, Zhenqiang |
| description | The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs).
We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5-100.1). The local tumor control rates (LTCRs) and overall survival rates were calculated to evaluate the results of the GKRS treatment.
At 2 months after GKRS, tumor volume was significantly reduced in 91 cases (61.9%). At 6 months, average tumor volume was 4.2 cm(3) as compared to 8.47 cm(3) before GKRS. By 1 year after GKRS, the tumor completely disappeared in 57 patients. Fourteen patients underwent second treatment, and one patient had third treatment. The overall survival rates were 72.1% at 3 years and 66.7% at 5 years for all patients and 62.4% at 3 years and 54.5% at 5 years for germ cell tumors (GCTs). The LTCRs were 94.30% at 3 years and 90.80% at 5 years for all patients and 88.00% at 3 years and 77.27% at 5 years for GCTs.
GKRS is an effective and safe modality that can be widely used to PRTs as the primary therapy. |
| doi_str_mv | 10.1186/s12957-015-0720-5 |
| format | Article |
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We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5-100.1). The local tumor control rates (LTCRs) and overall survival rates were calculated to evaluate the results of the GKRS treatment.
At 2 months after GKRS, tumor volume was significantly reduced in 91 cases (61.9%). At 6 months, average tumor volume was 4.2 cm(3) as compared to 8.47 cm(3) before GKRS. By 1 year after GKRS, the tumor completely disappeared in 57 patients. Fourteen patients underwent second treatment, and one patient had third treatment. The overall survival rates were 72.1% at 3 years and 66.7% at 5 years for all patients and 62.4% at 3 years and 54.5% at 5 years for germ cell tumors (GCTs). The LTCRs were 94.30% at 3 years and 90.80% at 5 years for all patients and 88.00% at 3 years and 77.27% at 5 years for GCTs.
GKRS is an effective and safe modality that can be widely used to PRTs as the primary therapy.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/s12957-015-0720-5</identifier><identifier>PMID: 26490154</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Care and treatment ; Child ; Comparative analysis ; Complications and side effects ; Female ; Follow-Up Studies ; Health aspects ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Pineal Gland ; Pinealoma - pathology ; Pinealoma - surgery ; Prognosis ; Radiosurgery ; Retrospective Studies ; Surgery ; Tumors ; Young Adult</subject><ispartof>World journal of surgical oncology, 2015-10, Vol.13 (1), p.304-304, Article 304</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Li et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-d518d7463421149400645c5148209ee808f6ad4bba5292a40f89f0a498507c843</citedby><cites>FETCH-LOGICAL-c525t-d518d7463421149400645c5148209ee808f6ad4bba5292a40f89f0a498507c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617952/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617952/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26490154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Wentao</creatorcontrib><creatorcontrib>Zhang, Binfei</creatorcontrib><creatorcontrib>Kang, Wenxing</creatorcontrib><creatorcontrib>Dong, Boning</creatorcontrib><creatorcontrib>Ma, Xudong</creatorcontrib><creatorcontrib>Song, Jinning</creatorcontrib><creatorcontrib>Liu, Yonghong</creatorcontrib><creatorcontrib>Liang, Zhenqiang</creatorcontrib><title>Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs).
We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5-100.1). The local tumor control rates (LTCRs) and overall survival rates were calculated to evaluate the results of the GKRS treatment.
At 2 months after GKRS, tumor volume was significantly reduced in 91 cases (61.9%). At 6 months, average tumor volume was 4.2 cm(3) as compared to 8.47 cm(3) before GKRS. By 1 year after GKRS, the tumor completely disappeared in 57 patients. Fourteen patients underwent second treatment, and one patient had third treatment. The overall survival rates were 72.1% at 3 years and 66.7% at 5 years for all patients and 62.4% at 3 years and 54.5% at 5 years for germ cell tumors (GCTs). The LTCRs were 94.30% at 3 years and 90.80% at 5 years for all patients and 88.00% at 3 years and 77.27% at 5 years for GCTs.
GKRS is an effective and safe modality that can be widely used to PRTs as the primary therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Pineal Gland</subject><subject>Pinealoma - pathology</subject><subject>Pinealoma - surgery</subject><subject>Prognosis</subject><subject>Radiosurgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl9vFCEUxYnR2Fr9AL4YEhNTH6YCcxnAB5Om0dXYaOKfZ8IysEudgRVmTPbby2Zr3TWGBwj8zrnh3oPQU0ouKJXdq0KZ4qIhlDdEMNLwe-iUghCNkFTdPzifoEel3BDC2pa3D9EJ60BVFZyiTwszjgb_iME7nE0fUpnzyuUtPl98_PL1JfYp402Izgw4u1VIEU_zmHJ5jQ0u09xvcfK4FsLWFFceowfeDMU9ud3P0Pd3b79dvW-uPy8-XF1eN5YzPjU9p7IX0LXAKAUFhHTALacgGVHOSSJ9Z3pYLg1nihkgXipPDCjJibAS2jP0Zu-7mZej662LUzaD3uQwmrzVyQR9_BLDWq_SLw0dFYqzanB-a5DTz9mVSY-hWDcMJro0F00FE9B2nRIVff4PepPmHOv3KiUqAEzQv9TKDE6H6FOta3em-pID5QSI3JW9-A9VV-_GYFN0PtT7I8GLA8G6jmFalzTMU51EOQbpHrQ5lZKdv2sGJXqXFr1Pi65z17u0aF41zw67eKf4E4_2N-DwtTY</recordid><startdate>20151021</startdate><enddate>20151021</enddate><creator>Li, Wentao</creator><creator>Zhang, Binfei</creator><creator>Kang, Wenxing</creator><creator>Dong, Boning</creator><creator>Ma, Xudong</creator><creator>Song, Jinning</creator><creator>Liu, Yonghong</creator><creator>Liang, Zhenqiang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151021</creationdate><title>Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases</title><author>Li, Wentao ; Zhang, Binfei ; Kang, Wenxing ; Dong, Boning ; Ma, Xudong ; Song, Jinning ; Liu, Yonghong ; Liang, Zhenqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-d518d7463421149400645c5148209ee808f6ad4bba5292a40f89f0a498507c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Pineal Gland</topic><topic>Pinealoma - pathology</topic><topic>Pinealoma - surgery</topic><topic>Prognosis</topic><topic>Radiosurgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wentao</creatorcontrib><creatorcontrib>Zhang, Binfei</creatorcontrib><creatorcontrib>Kang, Wenxing</creatorcontrib><creatorcontrib>Dong, Boning</creatorcontrib><creatorcontrib>Ma, Xudong</creatorcontrib><creatorcontrib>Song, Jinning</creatorcontrib><creatorcontrib>Liu, Yonghong</creatorcontrib><creatorcontrib>Liang, Zhenqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wentao</au><au>Zhang, Binfei</au><au>Kang, Wenxing</au><au>Dong, Boning</au><au>Ma, Xudong</au><au>Song, Jinning</au><au>Liu, Yonghong</au><au>Liang, Zhenqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2015-10-21</date><risdate>2015</risdate><volume>13</volume><issue>1</issue><spage>304</spage><epage>304</epage><pages>304-304</pages><artnum>304</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>The purpose of this study is to evaluate the effectiveness of gamma knife radiosurgery (GKRS) in the treatment of pineal region tumors (PRTs).
We retrospectively reviewed 147 cases of PRTs primarily treated with GKRS at our hospital between 1999 and 2009. Mean follow-up time was 67 months (range 60.5-100.1). The local tumor control rates (LTCRs) and overall survival rates were calculated to evaluate the results of the GKRS treatment.
At 2 months after GKRS, tumor volume was significantly reduced in 91 cases (61.9%). At 6 months, average tumor volume was 4.2 cm(3) as compared to 8.47 cm(3) before GKRS. By 1 year after GKRS, the tumor completely disappeared in 57 patients. Fourteen patients underwent second treatment, and one patient had third treatment. The overall survival rates were 72.1% at 3 years and 66.7% at 5 years for all patients and 62.4% at 3 years and 54.5% at 5 years for germ cell tumors (GCTs). The LTCRs were 94.30% at 3 years and 90.80% at 5 years for all patients and 88.00% at 3 years and 77.27% at 5 years for GCTs.
GKRS is an effective and safe modality that can be widely used to PRTs as the primary therapy.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26490154</pmid><doi>10.1186/s12957-015-0720-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Brain Neoplasms - pathology Brain Neoplasms - surgery Care and treatment Child Comparative analysis Complications and side effects Female Follow-Up Studies Health aspects Humans Male Middle Aged Neoplasm Staging Pineal Gland Pinealoma - pathology Pinealoma - surgery Prognosis Radiosurgery Retrospective Studies Surgery Tumors Young Adult |
| title | Gamma knife radiosurgery (GKRS) for pineal region tumors: a study of 147 cases |
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