In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart

The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and conce...

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Veröffentlicht in:	Cardiovascular research 2012-07, Vol.95 (1), p.69-76
Hauptverfasser:	DODD, Michael S, BALL, Daniel R, TYLER, Damian J, SCHROEDER, Marie A, LE PAGE, Lydia M, ATHERTON, Helen J, HEATHER, Lisa C, SEYMOUR, Anne-Marie, ASHRAFIAN, Houman, WATKINS, Hugh, CLARKE, Kieran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Arterial hypertension. Arterial hypotension Bicarbonates - metabolism Biological and medical sciences Blood and lymphatic vessels Carbon Dioxide - metabolism Cardiology. Vascular system Cardiomegaly - etiology Citric Acid Cycle Hydrogen-Ion Concentration Hypertension - complications Hypertension - metabolism Magnetic Resonance Imaging, Cine Male Medical sciences Myocardium - metabolism Pyruvate Dehydrogenase Complex - physiology Rats Rats, Inbred SHR Rats, Wistar
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