In vitro fertilization in women under 35: counseling should differ by age
Purpose The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2015-10, Vol.32 (10), p.1449-1457 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Humm, K. C. Dodge, L. E. Wu, L. H. Penzias, A. S. Malizia, B. A. Sakkas, D. Hacker, M. R. |
| description | Purpose
The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women |
| doi_str_mv | 10.1007/s10815-015-0570-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4615928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1727678338</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-565f49dc8412e1f8fc260302c67bf0e7502d27bde64e5d8f233db0164c1a7e5d3</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMotlZ_gBsJuHEzepJMPq4LQYofFwrd1HWYSU5uU-YmNZlpqb_eXG8ttVBwcUjI-5w3J3kJec3gPQPQHyoDw2QHu5IaOv2EHDKpRaeFgKdtD9J00CtzQF7UegEAK8PFc3LAldBNVIdkvU70Ks4l04BljlP8NcwxJxoTvc5bTHRJHgsV8iN1eUkVp5g2tJ7nZfLUx9C66HhDhw2-JM_CMFV8dbsekR9fv5wdf-9OTr-tjz-fdK5NNndSydCvvDM948iCCY4rEMCd0mMA1BK453r0qHqU3gQuhB-Bqd6xQbcTcUQ-7X0vl3GL3mGayzDZyxK3Q7mxeYj2XyXFc7vJV7ZXTK64aQbvbg1K_rlgne02VofTNCTMS7VMc620EeK_UCkZV39c3z5AL_JSUvuJHdUzI0UPjWJ7ypVca8FwNzcDu8vU7jO1sKuWqdWt5839B991_A2xAXwP1CalDZZ7Vz_q-hvLOatW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1724185340</pqid></control><display><type>article</type><title>In vitro fertilization in women under 35: counseling should differ by age</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Humm, K. C. ; Dodge, L. E. ; Wu, L. H. ; Penzias, A. S. ; Malizia, B. A. ; Sakkas, D. ; Hacker, M. R.</creator><creatorcontrib>Humm, K. C. ; Dodge, L. E. ; Wu, L. H. ; Penzias, A. S. ; Malizia, B. A. ; Sakkas, D. ; Hacker, M. R.</creatorcontrib><description><![CDATA[Purpose
The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years.
Methods
A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric.
Results
Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women <25 years, 1691 (23.3 %) women 25 to <30 years, and 5389 (74.4 %) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rates were 58 % (95 % CI 0.51–0.66) among women <25 years, 69 % (95 % CI 0.67–0.71) among women 25 to <30 years, and 64 % (95 % CI 0.63–0.65) among women 30 to <35 years.
Conclusions
Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.]]></description><identifier>ISSN: 1058-0468</identifier><identifier>ISSN: 1573-7330</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-015-0570-7</identifier><identifier>PMID: 26371056</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Age groups ; Assisted Reproduction Technologies ; Birth Rate ; Clinical outcomes ; Cohort analysis ; Cohort Studies ; Counseling ; Embryos ; Female ; Fertilization in Vitro - methods ; Fertilization in Vitro - statistics & numerical data ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Infertility, Female - therapy ; Infertility, Male - therapy ; Live Birth - epidemiology ; Male ; Maternal Age ; Medicine ; Medicine & Public Health ; Obstetrics ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Reproductive technologies ; Retrospective Studies ; Sperm Injections, Intracytoplasmic - statistics & numerical data ; Treatment Outcome ; Ultrasonic imaging</subject><ispartof>Journal of assisted reproduction and genetics, 2015-10, Vol.32 (10), p.1449-1457</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-565f49dc8412e1f8fc260302c67bf0e7502d27bde64e5d8f233db0164c1a7e5d3</citedby><cites>FETCH-LOGICAL-c573t-565f49dc8412e1f8fc260302c67bf0e7502d27bde64e5d8f233db0164c1a7e5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615928/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615928/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26371056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Humm, K. C.</creatorcontrib><creatorcontrib>Dodge, L. E.</creatorcontrib><creatorcontrib>Wu, L. H.</creatorcontrib><creatorcontrib>Penzias, A. S.</creatorcontrib><creatorcontrib>Malizia, B. A.</creatorcontrib><creatorcontrib>Sakkas, D.</creatorcontrib><creatorcontrib>Hacker, M. R.</creatorcontrib><title>In vitro fertilization in women under 35: counseling should differ by age</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description><![CDATA[Purpose
The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years.
Methods
A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric.
Results
Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women <25 years, 1691 (23.3 %) women 25 to <30 years, and 5389 (74.4 %) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rates were 58 % (95 % CI 0.51–0.66) among women <25 years, 69 % (95 % CI 0.67–0.71) among women 25 to <30 years, and 64 % (95 % CI 0.63–0.65) among women 30 to <35 years.
Conclusions
Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.]]></description><subject>Adult</subject><subject>Age groups</subject><subject>Assisted Reproduction Technologies</subject><subject>Birth Rate</subject><subject>Clinical outcomes</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Counseling</subject><subject>Embryos</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Fertilization in Vitro - statistics & numerical data</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility, Female - therapy</subject><subject>Infertility, Male - therapy</subject><subject>Live Birth - epidemiology</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Reproductive technologies</subject><subject>Retrospective Studies</subject><subject>Sperm Injections, Intracytoplasmic - statistics & numerical data</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><issn>1058-0468</issn><issn>1573-7330</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEUhoMotlZ_gBsJuHEzepJMPq4LQYofFwrd1HWYSU5uU-YmNZlpqb_eXG8ttVBwcUjI-5w3J3kJec3gPQPQHyoDw2QHu5IaOv2EHDKpRaeFgKdtD9J00CtzQF7UegEAK8PFc3LAldBNVIdkvU70Ks4l04BljlP8NcwxJxoTvc5bTHRJHgsV8iN1eUkVp5g2tJ7nZfLUx9C66HhDhw2-JM_CMFV8dbsekR9fv5wdf-9OTr-tjz-fdK5NNndSydCvvDM948iCCY4rEMCd0mMA1BK453r0qHqU3gQuhB-Bqd6xQbcTcUQ-7X0vl3GL3mGayzDZyxK3Q7mxeYj2XyXFc7vJV7ZXTK64aQbvbg1K_rlgne02VofTNCTMS7VMc620EeK_UCkZV39c3z5AL_JSUvuJHdUzI0UPjWJ7ypVca8FwNzcDu8vU7jO1sKuWqdWt5839B991_A2xAXwP1CalDZZ7Vz_q-hvLOatW</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Humm, K. C.</creator><creator>Dodge, L. E.</creator><creator>Wu, L. H.</creator><creator>Penzias, A. S.</creator><creator>Malizia, B. A.</creator><creator>Sakkas, D.</creator><creator>Hacker, M. 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C. ; Dodge, L. E. ; Wu, L. H. ; Penzias, A. S. ; Malizia, B. A. ; Sakkas, D. ; Hacker, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-565f49dc8412e1f8fc260302c67bf0e7502d27bde64e5d8f233db0164c1a7e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age groups</topic><topic>Assisted Reproduction Technologies</topic><topic>Birth Rate</topic><topic>Clinical outcomes</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Counseling</topic><topic>Embryos</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Fertilization in Vitro - statistics & numerical data</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility, Female - therapy</topic><topic>Infertility, Male - therapy</topic><topic>Live Birth - epidemiology</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Reproductive technologies</topic><topic>Retrospective Studies</topic><topic>Sperm Injections, Intracytoplasmic - statistics & numerical data</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Humm, K. C.</creatorcontrib><creatorcontrib>Dodge, L. E.</creatorcontrib><creatorcontrib>Wu, L. H.</creatorcontrib><creatorcontrib>Penzias, A. S.</creatorcontrib><creatorcontrib>Malizia, B. A.</creatorcontrib><creatorcontrib>Sakkas, D.</creatorcontrib><creatorcontrib>Hacker, M. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Humm, K. C.</au><au>Dodge, L. E.</au><au>Wu, L. H.</au><au>Penzias, A. S.</au><au>Malizia, B. A.</au><au>Sakkas, D.</au><au>Hacker, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro fertilization in women under 35: counseling should differ by age</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>32</volume><issue>10</issue><spage>1449</spage><epage>1457</epage><pages>1449-1457</pages><issn>1058-0468</issn><issn>1573-7330</issn><eissn>1573-7330</eissn><abstract><![CDATA[Purpose
The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years.
Methods
A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric.
Results
Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women <25 years, 1691 (23.3 %) women 25 to <30 years, and 5389 (74.4 %) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rates were 58 % (95 % CI 0.51–0.66) among women <25 years, 69 % (95 % CI 0.67–0.71) among women 25 to <30 years, and 64 % (95 % CI 0.63–0.65) among women 30 to <35 years.
Conclusions
Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>26371056</pmid><doi>10.1007/s10815-015-0570-7</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age groups Assisted Reproduction Technologies Birth Rate Clinical outcomes Cohort analysis Cohort Studies Counseling Embryos Female Fertilization in Vitro - methods Fertilization in Vitro - statistics & numerical data Gynecology Human Genetics Humans In vitro fertilization Infertility, Female - therapy Infertility, Male - therapy Live Birth - epidemiology Male Maternal Age Medicine Medicine & Public Health Obstetrics Pregnancy Pregnancy Rate Reproductive Medicine Reproductive technologies Retrospective Studies Sperm Injections, Intracytoplasmic - statistics & numerical data Treatment Outcome Ultrasonic imaging |
| title | In vitro fertilization in women under 35: counseling should differ by age |
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