Flow-cytometric visualization of C>U mRNA editing reveals the dynamics of the process in live cells

APOBEC1 is the catalytic subunit of the complex that edits ApolipoproteinB (ApoB) mRNA, which specifically deaminates cytidine 6666 to uracil in the human transcript. The editing leads to the generation of a stop codon, resulting in the synthesis of a truncated form of ApoB. We have developed a meth...

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Veröffentlicht in:	RNA biology 2015, Vol.12 (4), p.389-397
Hauptverfasser:	Severi, Francesco, Conticello, Silvestro G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Nucleus - metabolism Cytoplasm - metabolism Cytosine - metabolism Flow Cytometry - methods Humans Rats RNA Editing RNA, Messenger - metabolism Technical Paper Uracil - metabolism
Online-Zugang:	Volltext
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