Design criteria for synthetic riboswitches acting on transcription

Riboswitches are RNA-based regulators of gene expression composed of a ligand-sensing aptamer domain followed by an overlapping expression platform. The regulation occurs at either the level of transcription (by formation of terminator or antiterminator structures) or translation (by presentation or...

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Bibliographische Detailangaben
Veröffentlicht in:	RNA biology 2015-01, Vol.12 (2), p.221-231
Hauptverfasser:	Wachsmuth, Manja, Domin, Gesine, Lorenz, Ronny, Serfling, Robert, Findeiß, Sven, Stadler, Peter F, Mörl, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Galactosidase - genetics beta-Galactosidase - metabolism binding sites dose response Drug Design Escherichia coli - genetics Escherichia coli - metabolism gene expression Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Molecular Sequence Data Nucleic Acid Conformation oligonucleotides reporter genes Research Papers Riboswitch riboswitch design Structure-Activity Relationship Synthetic Biology synthetic riboswitch tandem riboswitch Theophylline - chemistry theophylline aptamer Thermodynamics transcription regulation Transcription, Genetic translation (genetics)
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