hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0

Production of ribosomes relies on more than 200 accessory factors to ensure the proper sequence of steps and faultless assembly of ribonucleoprotein machinery. Among trans-acting factors are numerous enzymes, including ribonucleases responsible for processing the large rRNA precursor synthesized by...

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Veröffentlicht in:	RNA biology 2015, Vol.12 (9), p.1010-1029
Hauptverfasser:	Tomecki, Rafal, Labno, Anna, Drazkowska, Karolina, Cysewski, Dominik, Dziembowski, Andrzej
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Carrier Proteins - metabolism Catalytic Domain - genetics Cell Proliferation - genetics DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Endoribonuclease Gene Expression Gene Knockdown Techniques Genes, rRNA Genetic Complementation Test HeLa Cells Humans Molecular Sequence Data Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Interaction Mapping Research Paper Ribosome Subunits, Small, Eukaryotic - metabolism RNA Precursors - genetics RNA Precursors - metabolism RNA Processing, Post-Transcriptional RNA, Ribosomal, 18S - genetics RNA, Ribosomal, 18S - metabolism RNA, Small Nucleolar rRNA rRNA processing Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment SSU processome U3 snoRNA UTP24
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