Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese
AIM： To examine an association between the cytotoxic Tlymphocyte antigen 4 （CTLA4） gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis （UC） and Crohn＇s disease （CD） in the Japanese.METHODS： We studied 108 patients with UC, 79...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-07, Vol.11 (27), p.4188-4193 |
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| creator | Machida, Haruhisa Tsukamoto, Kazuhiro Wen, Chun-Yang Narumi, Yukiko Shikuwa, Saburou Isomoto, Hajime Takeshima, Fuminao Mizuta, Yohei Niikawa, Norio Murata, Ikuo Kohno, Shigeru |
| description | AIM： To examine an association between the cytotoxic Tlymphocyte antigen 4 （CTLA4） gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis （UC） and Crohn＇s disease （CD） in the Japanese.METHODS： We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms （SNPs） in CTLA4, such as C-318T in the promoter region, A＋49 Gin exon 1 and G＋6230A in the 3＇ untranslated region （3＇-UTR） by a PCR-restriction fragment length polymorphism method, and to an （AT）, repeat polymorphism in 3＇-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using X^2 and Fisher exact tests.RESULTS： The frequency of ＂A/A＂ genotype at the G＋6230A SNP site was statistically lower in UC patients than in controls （3.7% vs 11.0%, P = 0.047, odds ratio （OR） = 0.311）. Moreover, the frequency of ＂G/G＂ genotype at the A＋49G SNP site was significantly higher in CD patients with fistula （48.6%） than those without it （26.2%）（P = 0.0388, OR=2.67）.CONCLUSION： The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese. |
| doi_str_mv | 10.3748/wjg.v11.i27.4188 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4615440</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>18023913</cqvip_id><wanfj_id>wjg200527009</wanfj_id><sourcerecordid>wjg200527009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-cf9d233df051b76638b454dba3970f9dd8bf3074ac44cfd1748edad25a09d2503</originalsourceid><addsrcrecordid>eNpVUUmP0zAYtRCIKQN3TihCI24pn7csF6SqYlUlLsOJg-U4duPi2Bk7nar_HketWE6W_Ba_54fQawxrWrPm_emwXz9ivLakXjPcNE_QihDclqRh8BStMEBdtpTUN-hFSgcAQiknz9ENrgDzqqlX6OcmpaCsnG3wRTDFFNx5DHEarCqkc9rptFxv73cbVpzsPBTWGyfHUc4hnosunLQrepu0TDpDxTzo4pucpNdJv0TPjHRJv7qet-jHp4_32y_l7vvnr9vNrlSMw1wq0_Y5WG-A466uKtp0jLO-k7StIWN90xkKNZOKMWV6nIvrXvaES8hCDvQWfbj4Tsdu1L3Sfo7SiSnaUcazCNKK_xFvB7EPj4JVmDO2GNxdDE7SG-n34hCO0efIIn8wAeCkBmgz7d31nRgejjrNYrRJaedy23BMomqAYkJIJsKFqGJIKWrzJwsGsQy3-Io8nMjDiWW4LHnzb4e_gutSmfD26jkEv3-wOWUn1S9jnRa4ycu2mNLfB4ah6Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68031222</pqid></control><display><type>article</type><title>Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Machida, Haruhisa ; Tsukamoto, Kazuhiro ; Wen, Chun-Yang ; Narumi, Yukiko ; Shikuwa, Saburou ; Isomoto, Hajime ; Takeshima, Fuminao ; Mizuta, Yohei ; Niikawa, Norio ; Murata, Ikuo ; Kohno, Shigeru</creator><creatorcontrib>Machida, Haruhisa ; Tsukamoto, Kazuhiro ; Wen, Chun-Yang ; Narumi, Yukiko ; Shikuwa, Saburou ; Isomoto, Hajime ; Takeshima, Fuminao ; Mizuta, Yohei ; Niikawa, Norio ; Murata, Ikuo ; Kohno, Shigeru</creatorcontrib><description>AIM： To examine an association between the cytotoxic Tlymphocyte antigen 4 （CTLA4） gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis （UC） and Crohn＇s disease （CD） in the Japanese.METHODS： We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms （SNPs） in CTLA4, such as C-318T in the promoter region, A＋49 Gin exon 1 and G＋6230A in the 3＇ untranslated region （3＇-UTR） by a PCR-restriction fragment length polymorphism method, and to an （AT）, repeat polymorphism in 3＇-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using X^2 and Fisher exact tests.RESULTS： The frequency of ＂A/A＂ genotype at the G＋6230A SNP site was statistically lower in UC patients than in controls （3.7% vs 11.0%, P = 0.047, odds ratio （OR） = 0.311）. Moreover, the frequency of ＂G/G＂ genotype at the A＋49G SNP site was significantly higher in CD patients with fistula （48.6%） than those without it （26.2%）（P = 0.0388, OR=2.67）.CONCLUSION： The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i27.4188</identifier><identifier>PMID: 16015687</identifier><language>eng</language><publisher>United States: Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan%Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521,Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523,Japan%Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara,Omura 856-8562, Japan%Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD ; Antigens, Differentiation - genetics ; Clinical Research ; Colitis, Ulcerative - genetics ; Crohn Disease - genetics ; CTLA-4 Antigen ; CTLA4 ; Female ; Gene Frequency ; Genotype ; Humans ; Japan ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; 基因多态性 ; 疾病调查 ; 等位基因</subject><ispartof>World journal of gastroenterology : WJG, 2005-07, Vol.11 (27), p.4188-4193</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-cf9d233df051b76638b454dba3970f9dd8bf3074ac44cfd1748edad25a09d2503</citedby><cites>FETCH-LOGICAL-c450t-cf9d233df051b76638b454dba3970f9dd8bf3074ac44cfd1748edad25a09d2503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615440/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615440/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16015687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machida, Haruhisa</creatorcontrib><creatorcontrib>Tsukamoto, Kazuhiro</creatorcontrib><creatorcontrib>Wen, Chun-Yang</creatorcontrib><creatorcontrib>Narumi, Yukiko</creatorcontrib><creatorcontrib>Shikuwa, Saburou</creatorcontrib><creatorcontrib>Isomoto, Hajime</creatorcontrib><creatorcontrib>Takeshima, Fuminao</creatorcontrib><creatorcontrib>Mizuta, Yohei</creatorcontrib><creatorcontrib>Niikawa, Norio</creatorcontrib><creatorcontrib>Murata, Ikuo</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><title>Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To examine an association between the cytotoxic Tlymphocyte antigen 4 （CTLA4） gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis （UC） and Crohn＇s disease （CD） in the Japanese.METHODS： We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms （SNPs） in CTLA4, such as C-318T in the promoter region, A＋49 Gin exon 1 and G＋6230A in the 3＇ untranslated region （3＇-UTR） by a PCR-restriction fragment length polymorphism method, and to an （AT）, repeat polymorphism in 3＇-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using X^2 and Fisher exact tests.RESULTS： The frequency of ＂A/A＂ genotype at the G＋6230A SNP site was statistically lower in UC patients than in controls （3.7% vs 11.0%, P = 0.047, odds ratio （OR） = 0.311）. Moreover, the frequency of ＂G/G＂ genotype at the A＋49G SNP site was significantly higher in CD patients with fistula （48.6%） than those without it （26.2%）（P = 0.0388, OR=2.67）.CONCLUSION： The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation - genetics</subject><subject>Clinical Research</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Crohn Disease - genetics</subject><subject>CTLA-4 Antigen</subject><subject>CTLA4</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>基因多态性</subject><subject>疾病调查</subject><subject>等位基因</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUUmP0zAYtRCIKQN3TihCI24pn7csF6SqYlUlLsOJg-U4duPi2Bk7nar_HketWE6W_Ba_54fQawxrWrPm_emwXz9ivLakXjPcNE_QihDclqRh8BStMEBdtpTUN-hFSgcAQiknz9ENrgDzqqlX6OcmpaCsnG3wRTDFFNx5DHEarCqkc9rptFxv73cbVpzsPBTWGyfHUc4hnosunLQrepu0TDpDxTzo4pucpNdJv0TPjHRJv7qet-jHp4_32y_l7vvnr9vNrlSMw1wq0_Y5WG-A466uKtp0jLO-k7StIWN90xkKNZOKMWV6nIvrXvaES8hCDvQWfbj4Tsdu1L3Sfo7SiSnaUcazCNKK_xFvB7EPj4JVmDO2GNxdDE7SG-n34hCO0efIIn8wAeCkBmgz7d31nRgejjrNYrRJaedy23BMomqAYkJIJsKFqGJIKWrzJwsGsQy3-Io8nMjDiWW4LHnzb4e_gutSmfD26jkEv3-wOWUn1S9jnRa4ycu2mNLfB4ah6Q</recordid><startdate>20050721</startdate><enddate>20050721</enddate><creator>Machida, Haruhisa</creator><creator>Tsukamoto, Kazuhiro</creator><creator>Wen, Chun-Yang</creator><creator>Narumi, Yukiko</creator><creator>Shikuwa, Saburou</creator><creator>Isomoto, Hajime</creator><creator>Takeshima, Fuminao</creator><creator>Mizuta, Yohei</creator><creator>Niikawa, Norio</creator><creator>Murata, Ikuo</creator><creator>Kohno, Shigeru</creator><general>Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan%Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521,Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523,Japan%Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara,Omura 856-8562, Japan%Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050721</creationdate><title>Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese</title><author>Machida, Haruhisa ; Tsukamoto, Kazuhiro ; Wen, Chun-Yang ; Narumi, Yukiko ; Shikuwa, Saburou ; Isomoto, Hajime ; Takeshima, Fuminao ; Mizuta, Yohei ; Niikawa, Norio ; Murata, Ikuo ; Kohno, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-cf9d233df051b76638b454dba3970f9dd8bf3074ac44cfd1748edad25a09d2503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD</topic><topic>Antigens, Differentiation - genetics</topic><topic>Clinical Research</topic><topic>Colitis, Ulcerative - genetics</topic><topic>Crohn Disease - genetics</topic><topic>CTLA-4 Antigen</topic><topic>CTLA4</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>基因多态性</topic><topic>疾病调查</topic><topic>等位基因</topic><toplevel>online_resources</toplevel><creatorcontrib>Machida, Haruhisa</creatorcontrib><creatorcontrib>Tsukamoto, Kazuhiro</creatorcontrib><creatorcontrib>Wen, Chun-Yang</creatorcontrib><creatorcontrib>Narumi, Yukiko</creatorcontrib><creatorcontrib>Shikuwa, Saburou</creatorcontrib><creatorcontrib>Isomoto, Hajime</creatorcontrib><creatorcontrib>Takeshima, Fuminao</creatorcontrib><creatorcontrib>Mizuta, Yohei</creatorcontrib><creatorcontrib>Niikawa, Norio</creatorcontrib><creatorcontrib>Murata, Ikuo</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machida, Haruhisa</au><au>Tsukamoto, Kazuhiro</au><au>Wen, Chun-Yang</au><au>Narumi, Yukiko</au><au>Shikuwa, Saburou</au><au>Isomoto, Hajime</au><au>Takeshima, Fuminao</au><au>Mizuta, Yohei</au><au>Niikawa, Norio</au><au>Murata, Ikuo</au><au>Kohno, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2005-07-21</date><risdate>2005</risdate><volume>11</volume><issue>27</issue><spage>4188</spage><epage>4193</epage><pages>4188-4193</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To examine an association between the cytotoxic Tlymphocyte antigen 4 （CTLA4） gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis （UC） and Crohn＇s disease （CD） in the Japanese.METHODS： We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms （SNPs） in CTLA4, such as C-318T in the promoter region, A＋49 Gin exon 1 and G＋6230A in the 3＇ untranslated region （3＇-UTR） by a PCR-restriction fragment length polymorphism method, and to an （AT）, repeat polymorphism in 3＇-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using X^2 and Fisher exact tests.RESULTS： The frequency of ＂A/A＂ genotype at the G＋6230A SNP site was statistically lower in UC patients than in controls （3.7% vs 11.0%, P = 0.047, odds ratio （OR） = 0.311）. Moreover, the frequency of ＂G/G＂ genotype at the A＋49G SNP site was significantly higher in CD patients with fistula （48.6%） than those without it （26.2%）（P = 0.0388, OR=2.67）.CONCLUSION： The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese.</abstract><cop>United States</cop><pub>Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan%Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521,Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523,Japan%Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara,Omura 856-8562, Japan%Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan</pub><pmid>16015687</pmid><doi>10.3748/wjg.v11.i27.4188</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigens, CD Antigens, Differentiation - genetics Clinical Research Colitis, Ulcerative - genetics Crohn Disease - genetics CTLA-4 Antigen CTLA4 Female Gene Frequency Genotype Humans Japan Male Middle Aged Polymorphism, Single Nucleotide 基因多态性 疾病调查 等位基因 |
| title | Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese |
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