The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells

The mammalian ortholog of Drosophila ecdysoneless (Ecd) gene product regulates Rb-E2F interaction and is required for cell cycle progression. Ecd is overexpressed in breast cancer and its overexpression predicts shorter survival in patients with ErbB2-positive tumors. Here, we demonstrate Ecd knock...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2015-04, Vol.14 (7), p.990-1000
Hauptverfasser:	Bele, Aditya, Mirza, Sameer, Zhang, Ying, Ahmad Mir, Riyaz, Lin, Simon, Kim, Jun Hyun, Gurumurthy, Channabasavaiah Basavaraju, West, William, Qiu, Fang, Band, Hamid, Band, Vimla
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carrier Proteins - physiology Cell Movement Cell Proliferation Cell Transformation, Neoplastic Cells, Cultured Female Humans Mammary Glands, Human - pathology Mice, Inbred NOD Mice, SCID Microtubule-Associated Proteins - metabolism Neoplasm Transplantation Proto-Oncogene Proteins p21(ras) - physiology
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