Cytokinetic abscission is an acute G1 event
Animal cell division ends with the cutting of the microtubule and membrane intercellular bridge connecting the 2 daughter cells. This process, known as cytokinetic abscission (abscission), is widely regarded as the last step of cytokinesis, i.e., the last step of the cell cycle. Major breakthroughs...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2014-11, Vol.13 (21), p.3436-3441 |
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| creator | Gershony, Ofir Pe'er, Tal Noach-Hirsh, Meirav Elia, Natalie Tzur, Amit |
| description | Animal cell division ends with the cutting of the microtubule and membrane intercellular bridge connecting the 2 daughter cells. This process, known as cytokinetic abscission (abscission), is widely regarded as the last step of cytokinesis, i.e., the last step of the cell cycle. Major breakthroughs have been recently achieved, illuminating mechanistic aspects of abscission; however, the timing of abscission with respect to the mammalian cell cycle remains unclear. In this study, we carefully measured the onset and progression of abscission in dividing cells expressing a G1 reporter. We conclude that abscission commences long after cells enter the G1 phase. Affiliating abscission with G1 is beyond semantics since it essentially postulates that the last step of the cell cycle is regulated in, and probably by, the following cycle. |
| doi_str_mv | 10.4161/15384101.2014.956486 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 3T3 Cells Animals Cell Cycle Proteins - deficiency Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cytokinesis DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fluorescent Antibody Technique G1 Phase HeLa Cells Humans Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Mice, Inbred BALB C Microscopy, Video Red Fluorescent Protein Time-Lapse Imaging |
| title | Cytokinetic abscission is an acute G1 event |
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