Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study

Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. 46 major salivary g...

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Veröffentlicht in:	Dento-maxillo-facial radiology 2015-02, Vol.44 (2), p.20140166-20140166
Hauptverfasser:	Aghaghazvini, L, Salahshour, F, Yazdani, N, Sharifian, H, Kooraki, S, Pakravan, M, Shakiba, M
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Sprache:	eng
Schlagworte:	Adenolymphoma - diagnosis Adenolymphoma - pathology Adenolymphoma - surgery Contrast Media Cross-Sectional Studies Dentistry Diagnosis, Differential Female Gadolinium DTPA Humans Magnetic Resonance Imaging - methods Male Salivary Gland Neoplasms - diagnosis Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - surgery
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container_title	Dento-maxillo-facial radiology
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creator	Aghaghazvini, L Salahshour, F Yazdani, N Sharifian, H Kooraki, S Pakravan, M Shakiba, M
description	Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time-signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) 43 s and WR180 = 4.6-22.0% Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak
doi_str_mv	10.1259/dmfr.20140166
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This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time-signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) <4.6%; (b) Tpeak <43 s and WR >22%; (c) Tpeak >43 s and WR180 = 4.6-22.0% Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak <43 s. A Tpeak <63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak <63.5 s. Two malignant tumours had Tpeak <43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout <4.60%, while 8 (80%) malignant tumours had a washout >4.60%. All Warthin tumours had a WR180 >22%, while two malignant tumours had a WR180 >22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours.]]></description><identifier>ISSN: 0250-832X</identifier><identifier>EISSN: 1476-542X</identifier><identifier>DOI: 10.1259/dmfr.20140166</identifier><identifier>PMID: 25299931</identifier><language>eng</language><publisher>England: The British Institute of Radiology</publisher><subject>Adenolymphoma - diagnosis ; Adenolymphoma - pathology ; Adenolymphoma - surgery ; Contrast Media ; Cross-Sectional Studies ; Dentistry ; Diagnosis, Differential ; Female ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Salivary Gland Neoplasms - diagnosis ; Salivary Gland Neoplasms - pathology ; Salivary Gland Neoplasms - surgery</subject><ispartof>Dento-maxillo-facial radiology, 2015-02, Vol.44 (2), p.20140166-20140166</ispartof><rights>2015 The Authors. 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This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time-signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) <4.6%; (b) Tpeak <43 s and WR >22%; (c) Tpeak >43 s and WR180 = 4.6-22.0% Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak <43 s. A Tpeak <63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak <63.5 s. Two malignant tumours had Tpeak <43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout <4.60%, while 8 (80%) malignant tumours had a washout >4.60%. All Warthin tumours had a WR180 >22%, while two malignant tumours had a WR180 >22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours.]]></description><subject>Adenolymphoma - diagnosis</subject><subject>Adenolymphoma - pathology</subject><subject>Adenolymphoma - surgery</subject><subject>Contrast Media</subject><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Salivary Gland Neoplasms - diagnosis</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Gland Neoplasms - surgery</subject><issn>0250-832X</issn><issn>1476-542X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLxDAUhYMoOj6WbiVLF1bzatpuBPENiiAjuAu3eWikTcakI8y_t-Oo6Oouzrnn3sOH0D4lx5SVzYnpXTpmhApCpVxDEyoqWZSCPa-jCWElKWrOnrfQds5vhBDBS7mJtljJmqbhdILsxSJA7zXWMQwJ8lDY8ApBW4PvH2-xiwkb75xNNgweBh8Djg738DYKGTr_AWmBXzoIJuNg46yD3OcjDJgX06-EPMzNYhdtOOiy3fueO-jp6nJ6flPcPVzfnp_dFZrX1VBIWxonatJULZNa1m1F6lZXwFuuOQVWl9QILqWhABrAMMMaSRypuAA2LvIddLrKnc3b3hptl506NUu-H_9UEbz6rwT_ql7ihxKSClqJMeDwOyDF97nNg-p91rYbC9o4z4rKkglCKspHa7Gy6hRzTtb9nqFELdGoJRr1g2b0H_z97df9w4J_Arp_i8U</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Aghaghazvini, L</creator><creator>Salahshour, F</creator><creator>Yazdani, N</creator><creator>Sharifian, H</creator><creator>Kooraki, S</creator><creator>Pakravan, M</creator><creator>Shakiba, M</creator><general>The British Institute of Radiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study</title><author>Aghaghazvini, L ; Salahshour, F ; Yazdani, N ; Sharifian, H ; Kooraki, S ; Pakravan, M ; Shakiba, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6e5df48097b26c68b708bc7a3b3c31a2851d4366d1aacaad2d2960f0734a2f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenolymphoma - diagnosis</topic><topic>Adenolymphoma - pathology</topic><topic>Adenolymphoma - surgery</topic><topic>Contrast Media</topic><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Salivary Gland Neoplasms - diagnosis</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Gland Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aghaghazvini, L</creatorcontrib><creatorcontrib>Salahshour, F</creatorcontrib><creatorcontrib>Yazdani, N</creatorcontrib><creatorcontrib>Sharifian, H</creatorcontrib><creatorcontrib>Kooraki, S</creatorcontrib><creatorcontrib>Pakravan, M</creatorcontrib><creatorcontrib>Shakiba, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Dento-maxillo-facial radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aghaghazvini, L</au><au>Salahshour, F</au><au>Yazdani, N</au><au>Sharifian, H</au><au>Kooraki, S</au><au>Pakravan, M</au><au>Shakiba, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study</atitle><jtitle>Dento-maxillo-facial radiology</jtitle><addtitle>Dentomaxillofac Radiol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>44</volume><issue>2</issue><spage>20140166</spage><epage>20140166</epage><pages>20140166-20140166</pages><issn>0250-832X</issn><eissn>1476-542X</eissn><abstract><![CDATA[Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Post-surgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time-signal intensity curves (TICs) were categorized as (a) Tpeak >43 s and washout ratio at 180 s (WR180) <4.6%; (b) Tpeak <43 s and WR >22%; (c) Tpeak >43 s and WR180 = 4.6-22.0% Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak ≤43 s, while one BNW had Tpeak <43 s. A Tpeak <63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak <63.5 s. Two malignant tumours had Tpeak <43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout <4.60%, while 8 (80%) malignant tumours had a washout >4.60%. All Warthin tumours had a WR180 >22%, while two malignant tumours had a WR180 >22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours.]]></abstract><cop>England</cop><pub>The British Institute of Radiology</pub><pmid>25299931</pmid><doi>10.1259/dmfr.20140166</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current)
subjects	Adenolymphoma - diagnosis Adenolymphoma - pathology Adenolymphoma - surgery Contrast Media Cross-Sectional Studies Dentistry Diagnosis, Differential Female Gadolinium DTPA Humans Magnetic Resonance Imaging - methods Male Salivary Gland Neoplasms - diagnosis Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - surgery
title	Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study
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