Recurrent asthma induced by toluene diisocyanate
A worker developed toluene diisocyanate induced asthma in 1974. On reassessment, 11 years after leaving the chemical plant where toluene diisocyanate was produced, he had no respiratory symptoms and normal bronchial reactivity in response to methacholine, and showed no reaction when challenged with...
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| Veröffentlicht in: | Thorax 1988-08, Vol.43 (8), p.660-662 |
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| creator | Banks, D E Rando, R J |
| description | A worker developed toluene diisocyanate induced asthma in 1974. On reassessment, 11 years after leaving the chemical plant where toluene diisocyanate was produced, he had no respiratory symptoms and normal bronchial reactivity in response to methacholine, and showed no reaction when challenged with a subirritant concentration of toluene diisocyanate. He developed asthma within five months of returning to the workplace. Repeat challenge testing showed bronchial hyperreactivity to methacholine and to the specific sensitising agent, toluene diisocyanate. This clinical pattern could be due to underlying toluene diisocyanate sensitivity with resolution and reappearance of hyperresponsiveness to methacholine and toluene diisocyanate reactivity associated with workplace toluene diisocyanate exposure. Alternatively, this worker may have developed sensitisation to toluene diisocyanate anew. |
| doi_str_mv | 10.1136/thx.43.8.660 |
| format | Article |
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On reassessment, 11 years after leaving the chemical plant where toluene diisocyanate was produced, he had no respiratory symptoms and normal bronchial reactivity in response to methacholine, and showed no reaction when challenged with a subirritant concentration of toluene diisocyanate. He developed asthma within five months of returning to the workplace. Repeat challenge testing showed bronchial hyperreactivity to methacholine and to the specific sensitising agent, toluene diisocyanate. This clinical pattern could be due to underlying toluene diisocyanate sensitivity with resolution and reappearance of hyperresponsiveness to methacholine and toluene diisocyanate reactivity associated with workplace toluene diisocyanate exposure. Alternatively, this worker may have developed sensitisation to toluene diisocyanate anew.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.43.8.660</identifier><identifier>PMID: 2845598</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Asthma - chemically induced ; Chemical Industry ; Cyanates - adverse effects ; Humans ; Male ; Methacholine Chloride ; Methacholine Compounds - adverse effects ; Occupational Diseases - chemically induced ; Recurrence ; Toluene 2,4-Diisocyanate - adverse effects</subject><ispartof>Thorax, 1988-08, Vol.43 (8), p.660-662</ispartof><rights>Copyright BMJ Publishing Group LTD Aug 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b438t-f9f2f33cbc95270cca9405fb71e05a2b94740c0ad790923a2e6241420c2e60773</citedby><cites>FETCH-LOGICAL-b438t-f9f2f33cbc95270cca9405fb71e05a2b94740c0ad790923a2e6241420c2e60773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC461411/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC461411/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2845598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banks, D E</creatorcontrib><creatorcontrib>Rando, R J</creatorcontrib><title>Recurrent asthma induced by toluene diisocyanate</title><title>Thorax</title><addtitle>Thorax</addtitle><description>A worker developed toluene diisocyanate induced asthma in 1974. On reassessment, 11 years after leaving the chemical plant where toluene diisocyanate was produced, he had no respiratory symptoms and normal bronchial reactivity in response to methacholine, and showed no reaction when challenged with a subirritant concentration of toluene diisocyanate. He developed asthma within five months of returning to the workplace. Repeat challenge testing showed bronchial hyperreactivity to methacholine and to the specific sensitising agent, toluene diisocyanate. This clinical pattern could be due to underlying toluene diisocyanate sensitivity with resolution and reappearance of hyperresponsiveness to methacholine and toluene diisocyanate reactivity associated with workplace toluene diisocyanate exposure. Alternatively, this worker may have developed sensitisation to toluene diisocyanate anew.</description><subject>Adult</subject><subject>Asthma - chemically induced</subject><subject>Chemical Industry</subject><subject>Cyanates - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Methacholine Chloride</subject><subject>Methacholine Compounds - adverse effects</subject><subject>Occupational Diseases - chemically induced</subject><subject>Recurrence</subject><subject>Toluene 2,4-Diisocyanate - adverse effects</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kM1LAzEQxYMotVZvXoUFD17cdfKxyebgQYpfUBBEzyGbzdot3d2aZMX-96a0FL14moH35s3jh9A5hgxjym_C_DtjNCsyzuEAjTHjRUqJ5IdoDMAg5VTwY3Ti_QIACozFCI1IwfJcFmMEr9YMztkuJNqHeauTpqsGY6ukXCehXw62s0nVNL43a93pYE_RUa2X3p7t5gS9P9y_TZ_S2cvj8_RulpaMFiGtZU1qSk1pZE4EGKMlg7wuBbaQa1JKJhgY0JWQIAnVxHLCMCNg4gZC0Am63eauhrK1lYkNnV6qlWta7daq1436q3TNXH30X4pxzCKXCbrc3bv-c7A-qEU_uC5WVlgITDEH2Hy53rqM6713tt4_wKA2dFWkqxhVhYp0o_3id6m9eYcz6ldbvWwX_yf9APi0gjM</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Banks, D E</creator><creator>Rando, R J</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>19880801</creationdate><title>Recurrent asthma induced by toluene diisocyanate</title><author>Banks, D E ; Rando, R J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b438t-f9f2f33cbc95270cca9405fb71e05a2b94740c0ad790923a2e6241420c2e60773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Asthma - chemically induced</topic><topic>Chemical Industry</topic><topic>Cyanates - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Methacholine Chloride</topic><topic>Methacholine Compounds - adverse effects</topic><topic>Occupational Diseases - chemically induced</topic><topic>Recurrence</topic><topic>Toluene 2,4-Diisocyanate - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banks, D E</creatorcontrib><creatorcontrib>Rando, R J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banks, D E</au><au>Rando, R J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent asthma induced by toluene diisocyanate</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>43</volume><issue>8</issue><spage>660</spage><epage>662</epage><pages>660-662</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>A worker developed toluene diisocyanate induced asthma in 1974. On reassessment, 11 years after leaving the chemical plant where toluene diisocyanate was produced, he had no respiratory symptoms and normal bronchial reactivity in response to methacholine, and showed no reaction when challenged with a subirritant concentration of toluene diisocyanate. He developed asthma within five months of returning to the workplace. Repeat challenge testing showed bronchial hyperreactivity to methacholine and to the specific sensitising agent, toluene diisocyanate. This clinical pattern could be due to underlying toluene diisocyanate sensitivity with resolution and reappearance of hyperresponsiveness to methacholine and toluene diisocyanate reactivity associated with workplace toluene diisocyanate exposure. Alternatively, this worker may have developed sensitisation to toluene diisocyanate anew.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>2845598</pmid><doi>10.1136/thx.43.8.660</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-6376 |
| ispartof | Thorax, 1988-08, Vol.43 (8), p.660-662 |
| issn | 0040-6376 1468-3296 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_461411 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Asthma - chemically induced Chemical Industry Cyanates - adverse effects Humans Male Methacholine Chloride Methacholine Compounds - adverse effects Occupational Diseases - chemically induced Recurrence Toluene 2,4-Diisocyanate - adverse effects |
| title | Recurrent asthma induced by toluene diisocyanate |
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