A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size

Leucine carboxyl methyltransferase-1 (LCMT1) and protein phosphatase methylesterase-1 (PME-1) are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit (PP2AC). LCMT1 and PME-1 have been linked to the regulation of cell growth and proliferation, but the unde...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2015-01, Vol.14 (12), p.1938-1947
Hauptverfasser:	Xia, Xiaoyu, Gholkar, Ankur, Senese, Silvia, Torres, Jorge Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Apoptosis Carboxylic Ester Hydrolases - chemistry Carboxylic Ester Hydrolases - genetics Caspase 3 - metabolism Cell Division Cell Survival HeLa Cells Humans Methylation Microscopy, Fluorescence Microtubules - metabolism Mitosis Phosphoprotein Phosphatases - metabolism Protein O-Methyltransferase - chemistry Protein O-Methyltransferase - genetics Protein Phosphatase 2C RNA Interference Spindle Apparatus - metabolism
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