Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway

Susceptibility to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) varies greatly among patients in sepsis/septic shock. The genetic and biochemical reasons for the difference are not fully understood. G protein coupled receptor family C group 5 member A (GPRC5A), a retinoic ac...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2015-05, Vol.14 (9), p.1403-1412
Hauptverfasser:	Liao, Yueling, Song, Hongyong, Xu, Dongliang, Jiao, Huike, Yao, Feng, Liu, Jingyi, Wu, Yadi, Zhong, Shuangshuang, Yin, Huijing, Liu, Shuli, Wang, Xiaofei, Guo, Wenzheng, Sun, Beibei, Han, Baohui, Chin, Y Eugene, Deng, Jiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - genetics Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - prevention & control Animals Cytokines - genetics Cytokines - metabolism Disease Models, Animal Endotoxins I-kappa B Proteins - genetics I-kappa B Proteins - metabolism Inflammation Mediators - metabolism Lung - metabolism Lung - pathology Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout NF-kappa B - genetics NF-kappa B - metabolism Pneumonia - chemically induced Pneumonia - metabolism Pneumonia - pathology Pulmonary Edema - chemically induced Pulmonary Edema - metabolism Pulmonary Edema - pathology Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Signal Transduction Time Factors Up-Regulation
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