Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico
Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, L...
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| Veröffentlicht in: | International journal of molecular sciences 2015-09, Vol.16 (9), p.21539-21554 |
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| creator | Cahua-Pablo, José Ángel Cruz, Miguel Méndez-Palacios, Abigail Antúnez-Ortiz, Diana Lizzete Vences-Velázquez, Amalia del Carmen Alarcón-Romero, Luz Parra, Esteban Juan Tello-Flores, Vianet Argelia Leyva-Vázquez, Marco Antonio Valladares-Salgado, Adán Pérez-Macedonio, Claudia Paola Flores-Alfaro, Eugenia |
| description | Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features. |
| doi_str_mv | 10.3390/ijms160921539 |
| format | Article |
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Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms160921539</identifier><identifier>PMID: 26370976</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Alleles ; Case-Control Studies ; Cholesterol Ester Transfer Proteins - genetics ; Cross-Sectional Studies ; Estrogen Receptor alpha - genetics ; Female ; Gene Frequency ; Genes ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Lipoprotein Lipase - genetics ; Metabolic disorders ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - genetics ; Mexico - epidemiology ; Middle Aged ; Polymorphism ; Polymorphism, Single Nucleotide ; Women</subject><ispartof>International journal of molecular sciences, 2015-09, Vol.16 (9), p.21539-21554</ispartof><rights>Copyright MDPI AG 2015</rights><rights>2015 by the authors; licensee MDPI, Basel, Switzerland. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-4d528db82637b74458efaa1798e6f6e2ee3363e8311f16f40b9e95525bab39b63</citedby><cites>FETCH-LOGICAL-c448t-4d528db82637b74458efaa1798e6f6e2ee3363e8311f16f40b9e95525bab39b63</cites><orcidid>0000-0002-3182-3857</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26370976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cahua-Pablo, José Ángel</creatorcontrib><creatorcontrib>Cruz, Miguel</creatorcontrib><creatorcontrib>Méndez-Palacios, Abigail</creatorcontrib><creatorcontrib>Antúnez-Ortiz, Diana Lizzete</creatorcontrib><creatorcontrib>Vences-Velázquez, Amalia</creatorcontrib><creatorcontrib>del Carmen Alarcón-Romero, Luz</creatorcontrib><creatorcontrib>Parra, Esteban Juan</creatorcontrib><creatorcontrib>Tello-Flores, Vianet Argelia</creatorcontrib><creatorcontrib>Leyva-Vázquez, Marco Antonio</creatorcontrib><creatorcontrib>Valladares-Salgado, Adán</creatorcontrib><creatorcontrib>Pérez-Macedonio, Claudia Paola</creatorcontrib><creatorcontrib>Flores-Alfaro, Eugenia</creatorcontrib><title>Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.</description><subject>Adult</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Cholesterol Ester Transfer Proteins - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Metabolic disorders</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - genetics</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Women</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkktv1DAUhSNERUthyRZZYtNNwK_4sUGqRkOLNKgjpoil5SQ3xKPEDnZCmV_BXyYzfahlxcK6vrqfj-6xTpa9Ifg9Yxp_cNs-EYE1JQXTz7ITwinNMRby-aP7cfYypS3GlNFCv8iOqWASaylOsj_r0O36EIfWpT4h59HYAlqtV8j6Gi2W12t0AR7Sob20QxfG3QD33HLzlRzm6DzOJ6VQOTtCjW7c2KIvMNoydK5Cm52vY-gP777P1aNmbtEmTGN7A2mE6Gf6t6vCq-yosV2C13f1NPv2aXm9uMxXVxefF-ervOJcjTmvC6rqUu2NlJLzQkFjLZFagWgEUADGBAPFCGmIaDguNeiioEVpS6ZLwU6zj7e6w1T2UFfgx2g7M0TX27gzwTrzdOJda36EX4YLwqjYC5zdCcTwc5o9mN6lCrrOeghTMkQxyahU-D9QSaiUgvM9-u4fdBum6OefmClNteRK85nKb6kqhpQiNA97E2z2qTBPUjHzbx-bfaDvY8D-AtJJs0s</recordid><startdate>20150908</startdate><enddate>20150908</enddate><creator>Cahua-Pablo, José Ángel</creator><creator>Cruz, Miguel</creator><creator>Méndez-Palacios, Abigail</creator><creator>Antúnez-Ortiz, Diana Lizzete</creator><creator>Vences-Velázquez, Amalia</creator><creator>del Carmen Alarcón-Romero, Luz</creator><creator>Parra, Esteban Juan</creator><creator>Tello-Flores, Vianet Argelia</creator><creator>Leyva-Vázquez, Marco Antonio</creator><creator>Valladares-Salgado, Adán</creator><creator>Pérez-Macedonio, Claudia Paola</creator><creator>Flores-Alfaro, Eugenia</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3182-3857</orcidid></search><sort><creationdate>20150908</creationdate><title>Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico</title><author>Cahua-Pablo, José Ángel ; Cruz, Miguel ; Méndez-Palacios, Abigail ; Antúnez-Ortiz, Diana Lizzete ; Vences-Velázquez, Amalia ; del Carmen Alarcón-Romero, Luz ; Parra, Esteban Juan ; Tello-Flores, Vianet Argelia ; Leyva-Vázquez, Marco Antonio ; Valladares-Salgado, Adán ; Pérez-Macedonio, Claudia Paola ; Flores-Alfaro, Eugenia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-4d528db82637b74458efaa1798e6f6e2ee3363e8311f16f40b9e95525bab39b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Cholesterol Ester Transfer Proteins - 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Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cahua-Pablo, José Ángel</au><au>Cruz, Miguel</au><au>Méndez-Palacios, Abigail</au><au>Antúnez-Ortiz, Diana Lizzete</au><au>Vences-Velázquez, Amalia</au><au>del Carmen Alarcón-Romero, Luz</au><au>Parra, Esteban Juan</au><au>Tello-Flores, Vianet Argelia</au><au>Leyva-Vázquez, Marco Antonio</au><au>Valladares-Salgado, Adán</au><au>Pérez-Macedonio, Claudia Paola</au><au>Flores-Alfaro, Eugenia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2015-09-08</date><risdate>2015</risdate><volume>16</volume><issue>9</issue><spage>21539</spage><epage>21554</epage><pages>21539-21554</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Metabolic syndrome (MetS) is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD). Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR) = 2.9; p = 0.013) in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04). Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006). In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001). In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>26370976</pmid><doi>10.3390/ijms160921539</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-3182-3857</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adult Alleles Case-Control Studies Cholesterol Ester Transfer Proteins - genetics Cross-Sectional Studies Estrogen Receptor alpha - genetics Female Gene Frequency Genes Genetic Association Studies Genetic Predisposition to Disease Genotype Haplotypes Humans Linkage Disequilibrium Lipoprotein Lipase - genetics Metabolic disorders Metabolic Syndrome - epidemiology Metabolic Syndrome - genetics Mexico - epidemiology Middle Aged Polymorphism Polymorphism, Single Nucleotide Women |
| title | Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico |
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